US3920822A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Inhibition of histamine activity with cyanoguanidines
Assignee: Smith Kline & French Laboratories Ltd
•
Filing: 1974-11-14
•
Granted: 1975-11-18
•
Expires: 1994-11-14
Abstract
Abstract The compounds are cyanoguanidines, for example N-cyano-N''methyl-N''''-(2-((3-hydroxy-2-pyridyl)methylthio)ethyl)-guanidine, which are inhibitors of histamine activity.
Inventors
- 👤 Graham John Durant
- 👤 John Colin Emmett
- 👤 Charon Robin Ganellin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 18:37
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/28; C07D213/30; A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; C07D213/32; C07D213/60; C07D213/62; C07D213/63; C07D213/65; C07D213/70; C07D213/72; C07D213/73
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
46 words
A PHARMACEUTICAL COMPOSITION TO INHIBIT H-2 HISTAMINE RECEPTORS, SAID H-2 HISTAMINE RECEPTORS BEING THOSE HISTAMINE RECEPTORS WHICH ARE NOT INHIBITED BY MEPYRAMINE BUT ARE INHIBITED BY BURIMAMIDDE, COMPRISING A PHARMACEUTICAL CARRIER AND, IN AN EFFECTIVE AMOUNT TO INHIBIT SAID RECEPTORS, A GUANIDINE COMPOUND OF THE FORMULA:
Claim 2
Dependent Claim
46 words
A PHARMACEUTICAL COMPOSITION TO INHIBIT H-2 HISTAMINE RECEPTORS, SAID H-2 HISTAMINE RECEPTORS BEING THOSE HISTAMINE RECEPTORS WHICH ARE NOT INHIBITED BY MEPYRAMINE BUT ARE INHIBITED BY BURIMAMIDDE, COMPRISING A PHARMACEUTICAL CARRIER AND, IN AN EFFECTIVE AMOUNT TO INHIBIT SAID RECEPTORS, A GUANIDINE COMPOUND OF THE FORMULA:
Claim 3
Dependent Claim
12 words
A pharmaceutical composition of claim 1 wherein the guanidine compound is N-cyano-N''-methyl-N''''-(2-((3-hydroxy-2-pyridyl)methylthio)ethyl)guanidine.
Claim 4
Dependent Claim
12 words
A pharmaceutical composition of claim 1 wherein the guanidine compound is N-cyano-N''-methyl-N''''-(2-((3-bromo-2-pyridyl)methylthio)ethyl)guanidine.
Claim 5
Dependent Claim
12 words
A pharmaceutical composition of claim 1 wherein the guanidine compound is N-cyano-N''-ethyl-N''''-(2-((3-bromo-2-pyridyl)methylthio)ethyl)guanidine.
Claim 6
Independent Claim
53 words
A method of inhibiting H-2 histamine receptors, said H-2 histamine receptors being those histamine receptors which are not inhibited by mepyramine but are inhibited by burimamide, which comprises administering to an animal in need of inhibition of said receptors in an effective amount to inhibit said receptors a guanidine compound of the formula:
Claim 7
Independent Claim
53 words
A method of inhibiting H-2 histamine receptors, said H-2 histamine receptors being those histamine receptors which are not inhibited by mepyramine but are inhibited by burimamide, which comprises administering to an animal in need of inhibition of said receptors in an effective amount to inhibit said receptors a guanidine compound of the formula:
Claim 8
Dependent Claim
11 words
A method of claim 5 wherein the guanidine compound is N-cyano-N''-methyl-N''''-(2-((3-hydroxy-2-pyridyl)methylthio)ethyl)guanidine.
Claim 9
Dependent Claim
11 words
A method of claim 5 wherein the guanidine compound is N-cyano-N''-methyl-N''''-(2-((3-bromo-2-pyridyl)methylthio)ethyl)guanidine.
Claim 10
Dependent Claim
11 words
A method of claim 5 wherein the guanidine compound is N-cyano-N''-ethyl-N''''-(2-((3-bromo-2-pyridyl)methylthio)ethyl)guanidine.
Claim 11
Independent Claim
37 words
A method of inhibiting gastric acid secretion which comprises administering internally to an animal in need of inhibition of gastric acid secretion in an effective amount to inhibit gastric acid secretion a guanidine compound of the formula:
Claim 12
Independent Claim
37 words
A method of inhibiting gastric acid secretion which comprises administering internally to an animal in need of inhibition of gastric acid secretion in an effective amount to inhibit gastric acid secretion a guanidine compound of the formula:
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-11-17 | 1979-05-19 | 1979-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-11-17 | 1983-05-19 | 1983-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-11-17 | 1987-05-19 | 1987-11-18 | $7700.00 | Window Closed / Lapsed |