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US4234500A
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Ethylenediamine platinum(II) and 1,2-diamino-cyclohexane platinum(II) pyrophosphate complexes
Assignee: Engelhard Minerals and Chemicals Corp
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Filing: 1979-03-07
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Granted: 1980-11-18
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Expires: 1999-03-07
Abstract
Abstract Ethylenediamine platinum(II) and 1,2-diaminocyclohexane platinum(II) pyrophosphate complexes are prepared by reaction of the appropriate diaquo platinum(II) salt with a pyrophosphate salt. These complexes possess pronounced anti-tumor activity and low toxicity and thus have high therapeutic indices.
Inventors
- 👤 James D. Hoeschele
- 👤 Alan R. Amundsen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 06:03
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
86 words
An amine platinum(II) pyrophosphate complex of the formula: [{Pt(A)}.sub.2 P.sub.2 O.sub.7 ] wherein A is a diamine of the formula: NR 1 R 2 --CHR 3 --CHR 4 --NR 5 R 6 in which R 1 -R 6 , taken separately, are selected from hydrogen or lower alkyl and R 3 and R 4 , taken together, represent the divalent radical: --CHR 7 --CHR 8 --CHR 9 --CHR 10 -- wherein R 7 -R 10 are selected from the group consisting of hydrogen and lower alkyl.
Claim 2
Dependent Claim
86 words
An amine platinum(II) pyrophosphate complex of the formula: [{Pt(A)}.sub.2 P.sub.2 O.sub.7 ] wherein A is a diamine of the formula: NR 1 R 2 --CHR 3 --CHR 4 --NR 5 R 6 in which R 1 -R 6 , taken separately, are selected from hydrogen or lower alkyl and R 3 and R 4 , taken together, represent the divalent radical: --CHR 7 --CHR 8 --CHR 9 --CHR 10 -- wherein R 7 -R 10 are selected from the group consisting of hydrogen and lower alkyl.
Claim 3
Dependent Claim
19 words
The complex according to claim 1 wherein R 1 -R 6 , taken separately, represent hydrogen or lower alkyl.
Claim 4
Dependent Claim
15 words
The complex according to claim 1 wherein each of R 1 -R 6 is hydrogen.
Claim 5
Dependent Claim
63 words
The complex according to claim 1 wherein R 1 , R 2 , R 5 and R 6 are selected from hydrogen or lower alkyl and R 3 and R 4 , taken together, represent the divalent radical: --CHR 7 --CHR 8 --CHR 9 --CHR 10 -- wherein R 7 -R 10 are selected from the group consisting of hydrogen and lower alkyl.
Claim 6
Dependent Claim
42 words
The complex according to claim 4 wherein R 1 , R 2 , R 5 and R 6 are hydrogen and R 3 and R 4 , taken together, represent the divalent radical: --CH 2 --CH 2 --CH 2 --CH 2 --.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-18 | 1984-05-19 | 1984-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-18 | 1988-05-19 | 1988-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-18 | 1992-05-19 | 1992-11-18 | $7700.00 | Window Closed / Lapsed |