US4230862A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antifertility compounds
Assignee: Eli Lilly and Co
•
Filing: 1978-08-03
•
Granted: 1980-10-28
•
Expires: 1998-08-03
Abstract
Abstract Derivatives of 3-phenyl-4-aroyl-1,2-dihydronaphthalenes and 1-aroyl-2-phenylnaphthalenes are useful both as antifertility agents and in suppressing the growth of mammary tumors.
Inventors
- 👤 Tulio Suarez
- 👤 C. David Jones
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:08
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; C07C; C07C45/00; C07C45/45; C07C45/455; C07C45/46; C07C45/61; C07C45/65; C07C45/67; C07C45/673; C07C45/68; C07C49/00; C07C49/76; C07C49/84; C07C59/00; C07C59/235; C07C59/245; C07C59/265
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
76 words
A compound of the formula ##STR19## in which X is --CH 2 --CH 2 -- or --CH═CH--; R is hydrogen, hydroxyl, or C 1 -C 5 alkoxy; R 1 is hydrogen, hydroxyl, or C 1 -C 5 alkoxy; and R 2 and R 3 taken together with the nitrogen to which they are bonded constitute a heterocyclic ring selected from the group consisting of pyrrolidino, piperidino, and hexamethyleneimino; and pharmaceutically acceptable non-toxic acid addition salts thereof.
Claim 2
Dependent Claim
76 words
A compound of the formula ##STR19## in which X is --CH 2 --CH 2 -- or --CH═CH--; R is hydrogen, hydroxyl, or C 1 -C 5 alkoxy; R 1 is hydrogen, hydroxyl, or C 1 -C 5 alkoxy; and R 2 and R 3 taken together with the nitrogen to which they are bonded constitute a heterocyclic ring selected from the group consisting of pyrrolidino, piperidino, and hexamethyleneimino; and pharmaceutically acceptable non-toxic acid addition salts thereof.
Claim 3
Dependent Claim
13 words
Compound of claim 2 in which X is --CH 2 --CH 2 --.
Claim 4
Dependent Claim
9 words
Compound of claim 1 in which X is --CH═CH--.
Claim 5
Dependent Claim
28 words
Compound of claim 2, in which R 2 and R 3 taken together with the nitrogen to which they are bonded constitute a pyrrolidino or a piperidino ring.
Claim 6
Dependent Claim
13 words
Compound of claim 4, in which R is C 1 -C 5 alkoxy.
Claim 7
Dependent Claim
9 words
Compound of claim 5, in which R is methoxy.
Claim 8
Dependent Claim
10 words
Compound of claim 6, in which R 1 is hydrogen.
Claim 9
Dependent Claim
13 words
Compound of claim 2, in which both R and R 1 are hydrogen.
Claim 10
Dependent Claim
15 words
Compound of claim 7, in the form of its pharmaceutically acceptable non-toxic acid addition salt.
Claim 11
Dependent Claim
11 words
Compound of claim 9, in the form of its citrate salt.
Claim 12
Dependent Claim
11 words
Compound of claim 9, in the form of a sulfonate salt.
Claim 13
Dependent Claim
10 words
Compound of claim 11, in the form of its mesylate.
Claim 14
Dependent Claim
14 words
Compound of claim 4, in which R 1 is C 1 -C 5 alkoxy.
Claim 15
Dependent Claim
10 words
Compound of claim 13, in which R 1 is methoxy.
Claim 16
Dependent Claim
9 words
Compound of claim 14, in which R is hydrogen.
Claim 17
Dependent Claim
13 words
Compound of claim 2, in which both R and R 1 is hydroxy.
Claim 18
Dependent Claim
15 words
Compound of claim 15, in the form of its pharmaceutically acceptable non-toxic acid addition salt.
Claim 19
Dependent Claim
11 words
Compound of claim 17, in the form of its citrate salt.
Claim 20
Dependent Claim
11 words
Compound of claim 17, in the form of a sulfonate salt.
Claim 21
Dependent Claim
10 words
Compound of claim 19, in the form of its mesylate.
Claim 22
Dependent Claim
17 words
Compound of claim 2, in which both R and R 1 are C 1 -C 5 alkoxy.
Claim 23
Dependent Claim
14 words
Compound of claim 2, in which R is hydroxy and R 1 is hydrogen.
Claim 24
Dependent Claim
14 words
Compound of claim 2, in which R is hydrogen and R 1 is hydroxy.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-28 | 1984-04-28 | 1984-10-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-28 | 1988-04-28 | 1988-10-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-28 | 1992-04-28 | 1992-10-28 | $7700.00 | Window Closed / Lapsed |