US4075223A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel antifertility agents
Assignee: Eli Lilly and Co
•
Filing: 1976-11-24
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Granted: 1978-02-21
•
Expires: 1996-11-24
Abstract
Abstract Derivatives of 2-aroyl-3-phenylindenes, 3-aroyl-4-phenyl-1,2-dihydronaphthalenes, and 1-phenyl-2-aroyl-naphthalenes are useful as antifertility agents.
Inventors
- 👤 Tulio Suarez
- 👤 C. David Jones
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 07:31
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; C07C; C07C45/00; C07C45/45; C07C45/46; C07C45/61; C07C45/65; C07C45/67; C07C45/673; C07C45/68
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
152 words
A compound of the formula ##STR16## in which X is --CH 2 --, --CH 2 -CH 2 -- or --CH═CH--; R and R 1 independently are hydrogen, hydroxyl, C 1 - to C 5 -alkoxy, or C 5 - to C 6 -cycloalkoxy; subject to the limitation that at least one of R and R 1 is hydrogen; R 2 is hydrogen, chloro, bromo, hydroxyl, C 1 - to C 5 -alkoxy, or C 5 - to C 6 -cycloalkoxy; subject to the limitation that at least one of R, R 1 , or R 2 is other than hydrogen; and R 4 and R 5 independently are C 1 -C 4 alkyl, or R 4 and R 5 taken together with the nitrogen to which they are bonded constitute a heterocyclic ring selected from the group consisting of pyrrolidino, piperidino, hexamethyleneimino, or morpholino; and pharmaceutically acceptable non-toxic acid addition salts thereof.
Claim 2
Dependent Claim
152 words
A compound of the formula ##STR16## in which X is --CH 2 --, --CH 2 -CH 2 -- or --CH═CH--; R and R 1 independently are hydrogen, hydroxyl, C 1 - to C 5 -alkoxy, or C 5 - to C 6 -cycloalkoxy; subject to the limitation that at least one of R and R 1 is hydrogen; R 2 is hydrogen, chloro, bromo, hydroxyl, C 1 - to C 5 -alkoxy, or C 5 - to C 6 -cycloalkoxy; subject to the limitation that at least one of R, R 1 , or R 2 is other than hydrogen; and R 4 and R 5 independently are C 1 -C 4 alkyl, or R 4 and R 5 taken together with the nitrogen to which they are bonded constitute a heterocyclic ring selected from the group consisting of pyrrolidino, piperidino, hexamethyleneimino, or morpholino; and pharmaceutically acceptable non-toxic acid addition salts thereof.
Claim 3
Dependent Claim
13 words
Compound of claim 1, in which X is --CH 2 -CH 2 --.
Claim 4
Dependent Claim
10 words
Compound of claim 2, in which R 1 is hydroxyl.
Claim 5
Dependent Claim
10 words
Compound of claim 2, in which R 2 is hydroxyl.
Claim 6
Dependent Claim
15 words
Compound of claim 4, in which the R 2 substituent is in the para position.
Claim 7
Dependent Claim
10 words
Compound of claim 5, in which R 1 is hydroxyl.
Claim 8
Dependent Claim
13 words
Compound of claim 2, in which R 4 and R 5 are methyl.
Claim 9
Dependent Claim
13 words
Compound of claim 2, in which R 4 and R 5 are ethyl.
Claim 10
Dependent Claim
25 words
Compound of claim 2, in which R 4 and R 5 taken together with the nitrogen to which they are bonded constitute a pyrrolidino function.
Claim 11
Dependent Claim
13 words
Compound of claim 2, in the form of its pharmaceutically acceptable non-toxic salt.
Claim 12
Dependent Claim
11 words
Compound of claim 10, in the form of its citrate salt.
Claim 13
Dependent Claim
11 words
Compound of claim 1, in which X is --CH 2 --.
Claim 14
Dependent Claim
10 words
Compound of claim 12, in which R 1 is hydroxyl.
Claim 15
Dependent Claim
10 words
Compound of claim 12, in which R 2 is hydroxyl.
Claim 16
Dependent Claim
15 words
Compound of claim 14, in which the R 2 substituent is in the para position.
Claim 17
Dependent Claim
10 words
Compound of claim 15, in which R 1 is hydroxyl.
Claim 18
Dependent Claim
10 words
Compound of claim 15, in which R 1 is methoxy.
Claim 19
Dependent Claim
9 words
Compound of claim 1, in which X is --CH═CH--.
References Cited (Backward Citations)
US2551316A
Cited
US4017546A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-02-20 | 1981-08-22 | 1982-02-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-02-20 | 1985-08-22 | 1986-02-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-02-20 | 1989-08-22 | 1990-02-21 | $7700.00 | Window Closed / Lapsed |