US4220643A
Expired / Lapsed
US
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Nitrosourea pentose compounds
Assignee: Individual
•
Filing: 1978-10-16
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Granted: 1980-09-02
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Expires: 1998-10-16
Abstract
Abstract Novel nitrosourea compounds are provided which possess a high level of inhibitory activity against leukemia and tumors with a low toxicity and which are therefore useful for pharmaceutical purposes. The compounds have the chemical structure: ##STR1## wherein ˜ represents a single bond which may be in the α- or β-position and are prepared by nitrosating a urea compound of the formula: ##STR2## with a nitrosating agent in a manner known per se.
Inventors
- 👤 Tetsuo Suami
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 03:43
CPC Classifications
C; C07; C07H; C07H13/00; C07H13/02; C07H13/08; A; A61; A61P; A61P35/00; C07H13/12
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
22 words
A nitrosourea compound of the formula: ##STR7## wherein ˜ represents a single bond which may be in either the α- or β-position.
Claim 2
Dependent Claim
22 words
A nitrosourea compound of the formula: ##STR7## wherein ˜ represents a single bond which may be in either the α- or β-position.
Claim 3
Dependent Claim
2 words
1-(2-Chloroethyl)-1-nitroso-3-(α-D-ribofuranosyl) urea.
Claim 4
Dependent Claim
2 words
1-(2-Chloroethyl)-1-nitroso-3-(α-D-ribofuranosyl) urea.
Claim 5
Dependent Claim
2 words
1-(2-Chloroethyl)-1-nitroso-3-(β-D-ribofuranosyl) urea.
Claim 6
Dependent Claim
2 words
1-(2-Chloroethyl)-1-nitroso-3-(β-D-ribofuranosyl) urea.
Claim 7
Dependent Claim
26 words
A pharmaceutical composition comprising an effective amount of a nitrosourea compound as defined in claim 1 in association with a pharmaceutically acceptable excipient, carrier or diluent.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-09-02 | 1984-03-03 | 1984-09-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-02 | 1988-03-03 | 1988-09-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-02 | 1992-03-03 | 1992-09-02 | $7700.00 | Window Closed / Lapsed |