US4057684A
Expired / Lapsed
US
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Alkyl amino-glucopyranoside derivative and process for producing the same
Assignee: Tanabe Pharma Corp
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Filing: 1975-06-20
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Granted: 1977-11-08
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Expires: 1995-06-20
Abstract
Abstract Certain alkyl amino-glucopyranoside are disclosed, including alkyl N-carbamyl-N'-(2-chloroethyl)-N'-nitroso-6-amino-6-deoxy-D-glucopyrano side, alkyl N-carbamyl-N'-(2-chloroethyl)-N'-nitroso-2-amino-2-deoxy-D-glucopyrano side, and alkyl di-N,N'-[N-(2-chloroethyl)-N-nitroso-carbamyl]-2,6-di-amino-2,6-di-deo xy-D-glucopyranoside. The alkyl amino-glucopryanoside exhibits marked antitumor activity while not having diabetogenic activity and bone marrow toxicity. The alkyl amino-glucopryanoside is further water soluble and free from antibacterial activity.
Inventors
- 👤 Goro Kimura
- 👤 Junzo Sekine
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 11:16
CPC Classifications
C; C07; C07H; C07H13/00; C07H13/12; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
40 words
An alkyl amino-glucopyranoside having the following formula: ##STR4## in which R 1 is an N-carbamyl-N'-(2-chloroethyl)-N'-nitroso-amino group, R 2 is an alkyl group having from 1 to 4 carbon atoms, and R 3 is an hydroxyl group or an N-carbamyl-N'-(2-chloro-ethyl)-N'-nitroso-amino group.
Claim 2
Dependent Claim
40 words
An alkyl amino-glucopyranoside having the following formula: ##STR4## in which R 1 is an N-carbamyl-N'-(2-chloroethyl)-N'-nitroso-amino group, R 2 is an alkyl group having from 1 to 4 carbon atoms, and R 3 is an hydroxyl group or an N-carbamyl-N'-(2-chloro-ethyl)-N'-nitroso-amino group.
Claim 3
Dependent Claim
12 words
Compound, according to claim 1, wherein R 3 is an N-carbamyl-N'-(2-chloroethyl)-N'-nitroso-amino group.
Claim 4
Dependent Claim
30 words
An alkyl amino-gluocopyranoside having the following formula: ##STR5## in which R 3 is an N-carbamyl-N'-(2-chloroethyl)-N'nitroso-amino group and R 2 is an alkyl group having from 1 to 4 carbon atoms.
Claim 5
Dependent Claim
30 words
An alkyl amino-gluocopyranoside having the following formula: ##STR5## in which R 3 is an N-carbamyl-N'-(2-chloroethyl)-N'nitroso-amino group and R 2 is an alkyl group having from 1 to 4 carbon atoms.
Claim 6
Dependent Claim
16 words
Compound, according to claim 1, in which R 2 is methyl and said compound is α-anomer.
Claim 7
Dependent Claim
16 words
Compound, according to claim 1, in which R 2 is methyl and said compound is β-anomer.
Claim 8
Dependent Claim
16 words
Compound, according to claim 3, in which R 2 is methyl and said compound is α-anomer.
Claim 9
Dependent Claim
16 words
Compound, according to claim 3, in which R 2 is methyl and said compound is β-anomer.
Claim 10
Dependent Claim
16 words
Compound, according to claim 2, in which R 2 is methyl and said compound is α-anomer.
Claim 11
Dependent Claim
16 words
Compound, according to claim 2, in which R 2 is methyl and said compound is β-anomer.
Claim 12
Dependent Claim
18 words
Compound, according to claim 3, in which R 2 is n-butyl and said compound is α-anomer or β-anomer.
Claim 13
Dependent Claim
16 words
Compound, according to claim 1, in which R 2 is n-propyl and said compound is α-anomer.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-07 | 1981-05-09 | 1981-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-07 | 1985-05-09 | 1985-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-07 | 1989-05-09 | 1989-11-08 | $7700.00 | Window Closed / Lapsed |