US4086415A
Expired / Lapsed
US
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Nitrosourea derivatives of glycosides
Assignee: Individual
•
Filing: 1975-07-30
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Granted: 1978-04-25
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Expires: 1995-07-30
Abstract
Abstract New nitrosourea derivatives are provided, which possess a high inhibitory activity against the leukemia and tumors with a low toxicity and which are useful for pharmaceutical purposes. The compounds have the formula ##STR1## WHEREIN A represents a glycosyl group, a monovalent residue of methyl glucoside or of alditol, a N-substituted carbamoyloxyalkyl group or a hydroxy-substituted cyclohexyl group when n is 1, or A represents a tetravalent residue of ribostamycin when n is 4 and R represents a lower alkyl or halo-alkyl group and are prepared by treating a compound of the formula ##STR2## WITH A NITROSATING AGENT.
Inventors
- 👤 Tetsuo Suami
- 👤 Tomoya Machinami
- 👤 Takashi Hisamatsu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 03:43
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/02; C07H15/12; A; A61; A61P; A61P35/00; A61P35/02; C07H15/20; C07H15/22; C07H15/222; C07H15/226; C07H15/228; C07H15/23
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
30 words
Nitrosourea of the formula: ##STR38## wherein A represents a glycosyl selected from the group consisting of maltosyl, glucosyl, mannosyl, galactosyl, xylosyl, and lactosyl and R represents a halo-substituted lower alkyl.
Claim 2
Dependent Claim
30 words
Nitrosourea of the formula: ##STR38## wherein A represents a glycosyl selected from the group consisting of maltosyl, glucosyl, mannosyl, galactosyl, xylosyl, and lactosyl and R represents a halo-substituted lower alkyl.
Claim 3
Dependent Claim
10 words
Nitrosourea as claimed in claim 1 wherein glucosyl is β-D-glucopyranosyl.
Claim 4
Dependent Claim
10 words
Nitrosourea as claimed in caim 1 wherein mannosyl is β-D-mannopyranosyl.
Claim 5
Dependent Claim
10 words
Nitrosourea as claimed in claim 1 wherein galactosyl is β-D-galactopyranosyl.
Claim 6
Dependent Claim
10 words
Nitrosourea as claimed in claim 1 wherein xylosyl is β-D-xylopyranosyl.
Claim 7
Dependent Claim
12 words
Nitrosourea as claimed in claim 1 wherein halosubstituted lower alkyl is chloroethyl.
Claim 8
Dependent Claim
10 words
Nitrosourea selected from: 1-(2-chloroethyl)-3-(β-D-glucopyranosyl)-1-nitrosourea; 1-(2-chloroethyl)-3-(β-D-mannopyranosyl)-1-nitrosourea; 1-(2-chloroethyl)-3-(β-D-galactopyranosyl)-1-nitrosourea; 1-(2-chloroethyl)-1-nitroso-3-(β-D-xylopyranosyl)urea; 1-(2-chloroethyl)-3-(β-D-maltosyl)-1-nitrosourea; and 1(2-chloroethyl)-3-(β-D-lactosyl)-1-nitrosourea.
Claim 9
Dependent Claim
10 words
Nitrosourea selected from: 1-(2-chloroethyl)-3-(β-D-glucopyranosyl)-1-nitrosourea; 1-(2-chloroethyl)-3-(β-D-mannopyranosyl)-1-nitrosourea; 1-(2-chloroethyl)-3-(β-D-galactopyranosyl)-1-nitrosourea; 1-(2-chloroethyl)-1-nitroso-3-(β-D-xylopyranosyl)urea; 1-(2-chloroethyl)-3-(β-D-maltosyl)-1-nitrosourea; and 1(2-chloroethyl)-3-(β-D-lactosyl)-1-nitrosourea.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-24 | 1981-10-24 | 1982-04-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-24 | 1985-10-24 | 1986-04-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-24 | 1989-10-24 | 1990-04-25 | $7700.00 | Window Closed / Lapsed |