Patent US4209531A successfully refreshed from Google Patents.
US4209531A
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Method for treating phenylketonuria
Assignee: Cincinnati Children's Hospital Medical Center
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Filing: 1978-09-13
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Granted: 1980-06-24
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Expires: 1998-09-13
Abstract
Abstract A method for improving motor and cognitive functions in mammalian subjects affected with phenylketonuria by administering a mixture of valine, isoleucine and leucine as a supplement to the restriction of phenylalanine content of their diets. The invention described herein was made in the course of work under a grant from the Department of Health, Education and Welfare.
Inventors
- 👤 Helen K. Berry
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 17:43
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195; A23; A23L; A23L33/00; A23L33/10; A23L33/17; A23L33/175; A61K38/00; A61K38/01
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
54 words
Method of improving motor and cognitive functions in mammalian subjects afflicted with phenylketonuria by administering to said subjects a mixture consisting essentially of valine, isoleucine and leucine in a ratio of about 1 to about 0.5 to about 1, respectively, in a total effective amount of said mixture to improve motor and cognitive functions.
Claim 2
Dependent Claim
54 words
Method of improving motor and cognitive functions in mammalian subjects afflicted with phenylketonuria by administering to said subjects a mixture consisting essentially of valine, isoleucine and leucine in a ratio of about 1 to about 0.5 to about 1, respectively, in a total effective amount of said mixture to improve motor and cognitive functions.
Claim 3
Independent Claim
56 words
The method of improving motor and cognitive functions in mammalian subjects afflicted with phenylketonuria by orally administering to said subjects a mixture consisting essentially of L-valine, L-isoleucine and L-leucine in a ratio of about 1 to about 0.5 to about 1, respectively, in a total effective amount of said mixture to improve motor and cognitive functions.
Claim 4
Independent Claim
56 words
The method of improving motor and cognitive functions in mammalian subjects afflicted with phenylketonuria by orally administering to said subjects a mixture consisting essentially of L-valine, L-isoleucine and L-leucine in a ratio of about 1 to about 0.5 to about 1, respectively, in a total effective amount of said mixture to improve motor and cognitive functions.
Claim 5
Dependent Claim
11 words
The method of claim 1 wherein said administration is conducted orally.
Claim 6
Dependent Claim
21 words
The method of claim 1 further comprising the step of dietetically restricting the phenylalanine content in the diet of said subjects.
References Cited (Backward Citations)
US3832465A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-06-24 | 1983-12-24 | 1984-06-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-06-24 | 1987-12-24 | 1988-06-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-06-24 | 1991-12-24 | 1992-06-24 | $7700.00 | Window Closed / Lapsed |