US3832465A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Injectable amino acid composition commensurate to the anabolic need of the body and method of using same
Assignee: Individual
•
Filing: 1972-08-17
•
Granted: 1974-08-27
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Expires: 1992-08-17
Abstract
Abstract Novel amino acid compositions suitable for intravenous alimentation are provided. They are composed by taking into account the fact that in intravenous alimentation, unlike ingestion, the administered amino acids do not pass through the liver before reaching other parts of the body. The compositions are ammonia-free, do not contain heretofore unidentified peptides and other impurities derived on protein hydrolysis, but contain cysteine, reduced amounts of methionine and increased amounts of branched-chain amino acids. They are tailored to the needs of the body at different ages and can be adapted to any desired requirement. Administered in recommended dosage the plasma-free amino acid content and proportion of the peripheral blood will remain within normal range.
Inventors
- 👤 H Ghadimi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 20:09
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415; A61K31/185; A61K31/19; A61K31/195; A61K38/00; A61K38/01; A61K38/04
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
33 words
The amino acid composition of claim 1, in which lysine is present in an amount between about 2.5 percent and about 11.0 percent of the total amount of amino acids in said composition.
Claim 2
Dependent Claim
38 words
The amino acid composition of claim 1, in which glutamic acid and aspartic acid are present each in an amount between about 0 percent and about 1.5 percent of the total amount of amino acids in said composition.
Claim 3
Dependent Claim
33 words
The amino acid composition of claim 1, in which arginine is present in an amount between about 3.5 percent and about 13.5 percent of the total amount of amino acids in said composition.
Claim 4
Dependent Claim
33 words
The amino acid composition of claim 1, in which tyrosine is present in an amount between about 0.5 percent and about 4 percent of the total amount of amino acids in said composition.
Claim 5
Dependent Claim
78 words
The amino acid composition of claim 1, in which the proportion of the branched-chain amino acids leucine to isoleucine to valine present in said composition is between about 1 : 1 : 1 and 2 : 1 : 1, lysine is present in an amount between about 2.5 percent and about 11.0 percent, and tyrosine is present in an amount between about 0.5 percent and about 4 percent of the total amount of amino acids in said composition.
Claim 6
Dependent Claim
93 words
The amino acid composition of claim 1, in which the proportion of the branched-chain amino acids leucine to isoleucine to valine present in said composition is between about 1 : 1 : 1 and about 2 : 1 : 1, lysine is present in an amount between about 2.5 percent and about 11.0 percent, arginine is present in an amount between about 3.5 percent and about 13.5 percent, and tyrosine is present in an amount between about 0.5 percent and about 4 percent of the total amount of amino acids in said composition.
Claim 7
Dependent Claim
37 words
The composition of claim 1 for intravenous administration to newborns, prematures and for the use in neonatal period, said composition containing dissolved in said aqueous vehicle the following L-amino acids in the following amounts in mg./100 ml.:
Claim 8
Dependent Claim
45 words
The composition of claim 5, in which part of the tyrosine is present in the amino acid composition in the form of a compound selected from the group consisting of tyrosinamide and a dipeptide selected from the group consisting of glycyl-tyrosine, tyrosyl-isoleucine, alanyl-tyrosine, and leucyl-tyrosine.
Claim 9
Dependent Claim
10 words
The composition of claim 8 having a pH of 8.0.
Claim 10
Dependent Claim
45 words
A process of supplying newborns, prematures or patients in the neonatal period with L-amino acids in amounts and proportions conforming to the anabolic need of the body, when the liver is bypassed, which comprises intravenously administering an effective amount of the composition of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1977-08-26 | 1978-02-25 | 1978-08-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1981-08-26 | 1982-02-25 | 1982-08-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1985-08-26 | 1986-02-25 | 1986-08-27 | $7700.00 | Window Closed / Lapsed |