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US4191740A
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Synthetic resin-base, antibiotic compositions containing amino acids
Assignee: Merck Patent GmbH
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Filing: 1977-10-26
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Granted: 1980-03-04
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Expires: 1997-10-26
Abstract
Abstract By adding amino acids to antibiotic-containing compositions having as a base polymethacrylates, acrylates or a mixture thereof, reproducible improved antibiotic-release properties are achieved.
Inventors
- 👤 Dietrich Heusser
- 👤 Elvira Dingeldein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 07:11
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0024; A61K31/00; A61K31/70; A61L; A61L24/00; A61L24/001; A61L24/0015; A61L24/0047; A61L24/0073; A61L27/00; A61L27/40; A61L27/44; A61L2300/00; A61L2300/40; A61L2300/404; A61L2300/406
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
94 words
A pharmaceutical composition consisting essentially of a base of fine pearl polymer spheroid, particles having diameters of 1-20 mm of methyl methacrylate-methyl acrylate copolymer, at least one antibiotic selected from gentamycin, erythromycin, lincomycin, clindamycin, novobiocin, vancomycin, fusidic acid, rifamycin, polymyxins, neomycin, kanamycin and tobramycin in antimicrobial amounts of about 0.2-15% by weight and an antibiotic-liberating agent, wherein the antibiotic liberating agent consists essentially of 0.3-5% by weight of at least one aliphatic, monoamino, monocarboxylic amino acid containing up to 5 carbon atoms selected from glycine, alanine, threonine, valine, serine, hydroxyproline, proline and mixtures thereof.
Claim 2
Dependent Claim
94 words
A pharmaceutical composition consisting essentially of a base of fine pearl polymer spheroid, particles having diameters of 1-20 mm of methyl methacrylate-methyl acrylate copolymer, at least one antibiotic selected from gentamycin, erythromycin, lincomycin, clindamycin, novobiocin, vancomycin, fusidic acid, rifamycin, polymyxins, neomycin, kanamycin and tobramycin in antimicrobial amounts of about 0.2-15% by weight and an antibiotic-liberating agent, wherein the antibiotic liberating agent consists essentially of 0.3-5% by weight of at least one aliphatic, monoamino, monocarboxylic amino acid containing up to 5 carbon atoms selected from glycine, alanine, threonine, valine, serine, hydroxyproline, proline and mixtures thereof.
Claim 3
Dependent Claim
20 words
The composition of claim 1, wherein the amount of antibiotic is 0.2 to 15 weight %, based on the polymer.
Claim 4
Dependent Claim
19 words
The composition of claim 1, wherein the amino acid is glycine in a content of about 1% by weight.
Claim 5
Dependent Claim
10 words
The composition of claim 1, wherein the antibiotic is gentamycin.
Claim 6
Dependent Claim
17 words
The composition of claim 1, wherein the particles have a diameter of from 7 to 10 mm.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-04 | 1983-09-03 | 1984-03-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-04 | 1987-09-03 | 1988-03-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-04 | 1991-09-03 | 1992-03-04 | $7700.00 | Window Closed / Lapsed |