US4189466A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Detection of rheumatoid factor by antibody sensitized microbial particles
Assignee: Technical Research Affiliates Inc
•
Filing: 1978-02-06
•
Granted: 1980-02-19
•
Expires: 1998-02-06
Abstract
Abstract Detection of antigens in a biological specimen of animal origin by means of antibody-sensitized microbial particles, which particles may be sensitized from a whole immunoglobulin fraction, an immunoglobulin fraction derived therefrom (IgG), a purified antibody fraction or the whole serum containing immunoglobulin molecules.
Inventors
- 👤 Herman Ainis
- 👤 Charles F. Lange
- 👤 Abraham S. Mark
- 👤 George H. Scherr
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 23:03
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/564; G01N2800/00; G01N2800/10; G01N2800/101; G01N2800/102; Y; Y10; Y10S; Y10S436/00; Y10S436/828
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
54 words
A method of testing for the presence of Rheumatoid Factor in a biological specimen of animal origin, comprising the step of combining the specimen containing the suspected Rheumatoid Factor with a protein A microbial cell suspension sensitized with free Fc fragments of IgG to which Rheumatoid Factor is specific, with resultant agglutination if positive.
Claim 2
Independent Claim
54 words
A method of testing for the presence of Rheumatoid Factor in a biological specimen of animal origin, comprising the step of combining the specimen containing the suspected Rheumatoid Factor with a protein A microbial cell suspension sensitized with free Fc fragments of IgG to which Rheumatoid Factor is specific, with resultant agglutination if positive.
Claim 3
Dependent Claim
16 words
A method according to claim 1 in which the wall of the microbial cell is fragmented.
Claim 4
Dependent Claim
39 words
A method according to claim 1 in which detection is quantitated by combining known serial dilutions of the specimen containing the suspected Rheumatoid Factor with a standard concentration of said suspension so sensitized with free Fc fragments of IgG.
Claim 5
Dependent Claim
16 words
A method according to claim 3 in which the wall of the microbial wall is fragmented.
Claim 6
Independent Claim
85 words
A method of testing for the presence of suspected Rheumatoid Factor in serum, comprising the step of combining the serum containing the suspected Rheumatoid Factor with a protein A containing microbial cell suspension sensitized with free Fc fragments of IgG to which Rheumatoid Factor is specific whereby agglutination occurs if the test is positive, and in which the test is quantitated by combining known serial dilutions of the specimen with a standard concentration of said free Fc fragments of IgG sensitized protein A microbial cells.
Claim 7
Independent Claim
85 words
A method of testing for the presence of suspected Rheumatoid Factor in serum, comprising the step of combining the serum containing the suspected Rheumatoid Factor with a protein A containing microbial cell suspension sensitized with free Fc fragments of IgG to which Rheumatoid Factor is specific whereby agglutination occurs if the test is positive, and in which the test is quantitated by combining known serial dilutions of the specimen with a standard concentration of said free Fc fragments of IgG sensitized protein A microbial cells.
Claim 8
Dependent Claim
16 words
A method according to claim 5 in which the wall of the microbial cell is fragmented.
References Cited (Backward Citations)
US3658982A
Cited
US3689632A
Cited
US3873684A
Cited
US3781414A
Cited
DE2322562A1
Cited
US3850798A
Cited
GB1406964A
Cited
US3995018A
Cited
US3850798B1
Cited
US3995018B1
Cited
US3995018B2
Cited
US3966898A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-02-18 | 1983-08-20 | 1984-02-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-02-18 | 1987-08-20 | 1988-02-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-02-18 | 1991-08-20 | 1992-02-19 | $7700.00 | Window Closed / Lapsed |