Patent US4183919A successfully refreshed from Google Patents.
US4183919A
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Antitumor glycosides, process for their preparation including intermediates therefor and their use
Assignee: Pfizer Italia SRL
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Filing: 1977-12-14
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Granted: 1980-01-15
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Expires: 1997-12-14
Abstract
Abstract Disclosed is a new class of antitumor glycoside antibiotics of the formula (IA): <IMAGE> (IA) wherein R is hydrogen or hydroxy; and X is <IMAGE> These compounds are prepared, using novel intermediates, by condensing the appropriate aglycone and amino-deoxy sugar to form the alpha -glycosidic linkage.
Inventors
- 👤 Giuseppe Cassinelli
- 👤 Federico Arcamone
- 👤 Aurelio Di Marco
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 15:46
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/02; C07H15/04; A; A61; A61P; A61P35/00; C07H15/12; C07H15/20; C07H15/24; C07H15/252
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
20 words
A compound of the formula: ##STR17## wherein R is hydrogen or hydroxy; and X is ##STR18## and the hydrochlorides thereof.
Claim 2
Dependent Claim
20 words
A compound of the formula: ##STR17## wherein R is hydrogen or hydroxy; and X is ##STR18## and the hydrochlorides thereof.
Claim 3
Dependent Claim
9 words
A compound according to claim 1, which is 4'-O-methyl-daunomycin.
Claim 4
Dependent Claim
9 words
A compound according to claim 1, which is 4'-O-methyl-adriamycin.
Claim 5
Dependent Claim
9 words
A compound according to claim 1, which is 4'-epi-4'-O-methyl-daunomycin.
Claim 6
Dependent Claim
9 words
A compound according to claim 1, which is 4'-epi-4'-O-methyl-adriamycin.
Claim 7
Dependent Claim
12 words
An N-trifluoroacetyl protected glycoside of the formula: ##STR19## wherein X is ##STR20##
Claim 8
Dependent Claim
12 words
An N-trifluoroacetyl protected glycoside of the formula: ##STR19## wherein X is ##STR20##
Claim 9
Dependent Claim
42 words
A method of inhibiting the growth of P 388 leukemia and L 1210 leukemia in a host afflicted therewith, said method comprising intraperitoneally administering to said host a compound according to claim 1 in an amount sufficient to inhibit the growth thereof.
Claim 10
Dependent Claim
26 words
A pharmaceutical composition for inhibiting the growth of P 388 leukemia comprising a compound of claim 1 in an amount sufficient to inhibit the growth thereof.
References Cited (Backward Citations)
US3976667A
Cited
US4067969A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-01-14 | 1983-07-16 | 1984-01-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-01-14 | 1987-07-16 | 1988-01-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-01-14 | 1991-07-16 | 1992-01-15 | $7700.00 | Window Closed / Lapsed |