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US4179515A
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Benzoylphenoxy propionic acid, esters thereof and pharmaceutical composition
Assignee: Orchimed SA
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Filing: 1977-10-28
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Granted: 1979-12-18
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Expires: 1997-10-28
Abstract
Abstract Compounds of the formula ##STR1## in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X 4 and X 5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X 0 is O or OCH 2 CH 2 O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholosterolaemiant and cholagogic agents or in the preparation of such agents.
Inventors
- 👤 Andre Mieville
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 21:03
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/28; C07D213/30; C07C; C07C205/00; C07C205/27; C07C205/35; C07C205/45; C07C327/00; C07C45/00; C07C45/45; C07C45/46; C07C45/61; C07C45/64; C07C45/67; C07C45/673; C07C59/00; C07C59/40; C07C59/58; C07C59/64; C07C59/66; C07C59/68; C07C59/76; C07C59/90; C07D213/60; C07D213/62; C07D213/63; C07D213/65; C07D213/66; C07D213/67; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; C07D295/16; C07D295/18; C07D295/182; C07D295/185; C07D307/00; C07D307/02; C07D307/34; C07D307/38; C07D307/40; C07D307/46; C07D307/56; C07D307/77; C07D307/78; C07D307/79; C07D307/80; C07D317/00; C07D317/08; C07D317/10; C07D317/14; C07D317/18; C07D317/22; C07D333/00; C07D333/02; C07D333/04; C07D333/06; C07D333/22; C07D333/26; C07D333/28
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
75 words
A compound of the formula: ##STR226## wherein A represents 2-methylphenyl, 2,6-dimethylphenyl, 4-ethylphenyl, 4-methoxyphenyl, 3,4,5-trimethoxyphenyl, 4-nitrophenyl, 4-aminophenyl, 4-trifluoromethylphenyl, 3-trifluoromethylphenyl or 4-chloro-3-methoxyphenyl; R, X 4 and X 5 are the same or different and represent hydrogen or C 1-4 alkyl; Y represents OH or C 1-12 alkoxy; and X o represents oxygen if Y is OH or represents oxygen or the --O--CH 2 --CH 2 --O--group if Y is C 1-12 alkoxy; or an acid addition thereof.
Claim 2
Dependent Claim
75 words
A compound of the formula: ##STR226## wherein A represents 2-methylphenyl, 2,6-dimethylphenyl, 4-ethylphenyl, 4-methoxyphenyl, 3,4,5-trimethoxyphenyl, 4-nitrophenyl, 4-aminophenyl, 4-trifluoromethylphenyl, 3-trifluoromethylphenyl or 4-chloro-3-methoxyphenyl; R, X 4 and X 5 are the same or different and represent hydrogen or C 1-4 alkyl; Y represents OH or C 1-12 alkoxy; and X o represents oxygen if Y is OH or represents oxygen or the --O--CH 2 --CH 2 --O--group if Y is C 1-12 alkoxy; or an acid addition thereof.
Claim 3
Dependent Claim
25 words
The compound as defined in claim 1 wherein R is CH 3 , X 4 and X 5 are hydrogen and X o is oxygen.
Claim 4
Dependent Claim
33 words
A pharmaceutical composition for the treatment of hyperlipaemia comprising a therapeutically active amount of a compound as claimed in claim 1 or a non-toxic acid-addition salt thereof, and a physiologically acceptable pharmaceutical excipient.
Claim 5
Dependent Claim
2 words
Diethylaminoethyl 2-[(4-benzoyl)-phenoxy]-2-methylpropionate.
Claim 6
Dependent Claim
2 words
Diethylaminoethyl 2-[(4-benzoyl)-phenoxy]-2-methylpropionate.
Claim 7
Dependent Claim
2 words
Isopropyl 2-[4-(p-hydroxybenzoyl)-phenoxy]-2-methylpropionate.
Claim 8
Dependent Claim
2 words
Isopropyl 2-[4-(p-hydroxybenzoyl)-phenoxy]-2-methylpropionate.
Claim 9
Dependent Claim
2 words
Isopropyl 2-[4-(p-nitrobenzoyl)-phenoxy]-2-methylpropionate.
Claim 10
Dependent Claim
2 words
Isopropyl 2-[4-(p-nitrobenzoyl)-phenoxy]-2-methylpropionate.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-17 | 1983-06-18 | 1983-12-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-17 | 1987-06-18 | 1987-12-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-17 | 1991-06-18 | 1991-12-18 | $7700.00 | Window Closed / Lapsed |