(1-oxo-2-alkylideneindanyloxy) and (1-oxo - 2 - alkylideneindanylthio) alkanoic acids
Abstract
Abstract (1-OXO-2-ALKYLIDENEINDANYLOXY) AND (1-OXO-2-ALKYLIDENEINDANYLTHIO) ALKANOIC ACID PRODUCTS AND SALTS, ESTERS AND AMIDE DERIVATIVES THEREOF WHEREIN THE 1-OXO-2-ALKYLIDENEINDANYL RING MAY BE SUBSTITUTED BY VARIOUS RADICALS ARE DISCLOSED. THE PRODUCTS MAY BE PREPARED BY FOUR ROUTES: (1) VIA THE DEHYDROHOLOGENATION OF A (1-OXO-2HALO-2-ALKYLINDANYLOXY (OR THIO))ALKANOIC ACID; (2) VIA THE HYDROLYSIS OF A (1-OXO-2-ALKYLIDENEINDANYLOXY (OR THIO))ALKANOIC ACID ESTER; (3) VIA THE ETHERIFICATION OF A HYDROXY (OR MERCAPTO)-2-ALKYLIDENE-1-INDANONE, OR (4) WHEN THE ALKYLENE MOIETY IS METHYLENE, VIA THE MANNICH REACTION BY TREATING A (1-OXOINDANYLOXY (OR THIO)) ALKANOIC ACID WITH A SALT OF A SECONDARY AMINE IN THE PRESENCE OF FORMALDEHYDE OR PARAFORMALDEHYDE FOLLOWED BY TREATMENT OF THE MANNICH INTERMEDIATE WITH A WEAK BASE. THE PRODUCTS THUS OBTAINED ARE DIURETICS AND SALURETICS USEFUL IN THE TREATMENT OF EDEMA AND HYPERTENSION.
Inventors
- 👤 Edward J Cragoe Jr
- 👤 Otto W Woltersdorf Jr
Bibliographic Details
Claims Analysis
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