US4176235A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted acyl derivatives of amino acids
Assignee: ER Squibb and Sons LLC
•
Filing: 1978-12-04
•
Granted: 1979-11-27
•
Expires: 1998-12-04
Abstract
Abstract New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
Inventors
- 👤 Miguel A. Ondetti
- 👤 Frank L. Weisenborn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 01:02
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/60; C07C; C07C323/00; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
91 words
A compound of the formula ##STR19## and salts thereof, wherein R 1 is hydroxy or lower alkoxy; R 2 is hydrogen, lower alkyl or lower alkanoyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, lower alkanoyl, benzoyl or ##STR20## A is hydrogen, lower alkyl or hydroxy-lower alkylene; B is hydrogen, lower alkyl, hydroxy-lower alkylene, amino-lower alkylene, guanidino-lower alkylene, mercapto-lower alkylene, lower alkylmercapto-lower alkylene, carbamoyl-lower alkylene or carboxy lower alkylene; X is oxygen or sulfur; m is 0, 1 2, 3 or 4; and n is 0 or 1.
Claim 2
Dependent Claim
91 words
A compound of the formula ##STR19## and salts thereof, wherein R 1 is hydroxy or lower alkoxy; R 2 is hydrogen, lower alkyl or lower alkanoyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, lower alkanoyl, benzoyl or ##STR20## A is hydrogen, lower alkyl or hydroxy-lower alkylene; B is hydrogen, lower alkyl, hydroxy-lower alkylene, amino-lower alkylene, guanidino-lower alkylene, mercapto-lower alkylene, lower alkylmercapto-lower alkylene, carbamoyl-lower alkylene or carboxy lower alkylene; X is oxygen or sulfur; m is 0, 1 2, 3 or 4; and n is 0 or 1.
Claim 3
Dependent Claim
26 words
A compound as in claim 1 wherein ##STR21## is the radical of glycine, alanine, threonine, lysine, arginine, glutamine, methionine, serine, cysteine, valine, asparagine or, glutamic acid.
Claim 4
Dependent Claim
63 words
A compound as in claim 1 wherein R 1 is hydroxy; R 2 is hydrogen, lower alkyl or lower alkanoyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, lower alkanoyl or benzoyl; X is oxygen or sulfur; A is hydrogen; B is lower alkyl, guanidino-lower alkylene or amino-lower alkylene; m is 0 or 1 and n is 0 or 1.
Claim 5
Dependent Claim
11 words
A compound as in claim 1 wherein R 4 is ##STR22##
Claim 6
Dependent Claim
10 words
A compound as in claim 1 wherein X is oxygen.
Claim 7
Dependent Claim
10 words
A compound as in claim 1 wherein X is sulfur.
Claim 8
Dependent Claim
36 words
A compound as in claim 1 wherein R 1 is hydroxy; A, R 2 , R 3 and R 4 each is hydrogen; B is isobutyl; X is sulfur; and m and n each is 1.
Claim 9
Dependent Claim
36 words
A compound as in claim 1 wherein R 1 is hydroxy; A, R 2 , R 3 and R 4 each is hydrogen; B is 3-guanidinopropyl; X is sulfur; and m and n each is 1.
Claim 10
Dependent Claim
36 words
A compound as in claim 1 wherein R 1 is hydroxy; A, R 2 , R 3 and R 4 each is hydrogen; B is 4-aminobutyl; X is oxygen; and m and n each is 1.
Claim 11
Dependent Claim
36 words
A compound as in claim 1 wherein R 1 is hydroxy; A, R 2 , R 3 and R 4 each is hydrogen; B is isobutyl; X is oxygen; and m and n each is 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-11-26 | 1983-05-28 | 1983-11-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-11-26 | 1987-05-28 | 1987-11-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-11-26 | 1991-05-28 | 1991-11-27 | $7700.00 | Window Closed / Lapsed |