Patent US4171431A successfully refreshed from Google Patents.
US4171431A
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Nucleosides and process
Assignee: Pharmacia and Upjohn Co
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Filing: 1977-06-01
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Granted: 1979-10-16
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Expires: 1997-06-01
Abstract
Abstract Novel 5,6-dihydro-syn(s)-triazine nucleosides and nucleotides and a novel process for preparing the same. The novel nucleosides and nucleotides are disclosed as active in vitro and/or in vivo against susceptible DNA viruses.
Inventors
- 👤 Harvey I. Skulnick
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 13:00
CPC Classifications
C; C07; C07H; C07H13/00; C07H13/02; C07H13/08; A; A61; A61P; A61P31/00; A61P31/12; C07D; C07D251/00; C07D251/02; C07D251/10; C07D251/12; C07D251/14; C07D251/16; C07D251/20; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/18; C07F7/1804; C07H15/00; C07H15/02; C07H15/04; C07H19/00; C07H19/02; C07H19/04; C07H19/12; C07H23/00
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
73 words
A compound of the formula: ##STR11## wherein R' is selected from the group consisting of hydrogen and lower-alkyl: Y is selected from the group consisting of hydrogen, carboxacyl of from 1 through 18 carbon atoms, and phosphono; Y' is selected from the group consisting of carboxacyl of 1 through 18 and hydrogen; R is selected from the group consisting of hydrogen, lower-alkyl, phenyl, benzyl, cyclopropyl, lower-alkoxylower-alkyl, and lower-alkylthiolower-alkyl; and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
73 words
A compound of the formula: ##STR11## wherein R' is selected from the group consisting of hydrogen and lower-alkyl: Y is selected from the group consisting of hydrogen, carboxacyl of from 1 through 18 carbon atoms, and phosphono; Y' is selected from the group consisting of carboxacyl of 1 through 18 and hydrogen; R is selected from the group consisting of hydrogen, lower-alkyl, phenyl, benzyl, cyclopropyl, lower-alkoxylower-alkyl, and lower-alkylthiolower-alkyl; and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
73 words
A compound of the formula: ##STR12## wherein R' is selected from the group consisting of hydrogen and lower-alkyl; Y is selected from the group consisting of hydrogen, carboxacyl of from 1 through 18 carbon atoms, and phosphono; Y' is selected from the group consisting of carboxacyl of 1 through 18 and hydrogen: R is selected from the group consisting of hydrogen, lower-alkyl, phenyl, benzyl, cyclopropyl, lower-alkoxylower-alkyl, and lower-alkylthiolower-alkyl; and pharmaceutically acceptable salts thereof.
Claim 4
Dependent Claim
73 words
A compound of the formula: ##STR12## wherein R' is selected from the group consisting of hydrogen and lower-alkyl; Y is selected from the group consisting of hydrogen, carboxacyl of from 1 through 18 carbon atoms, and phosphono; Y' is selected from the group consisting of carboxacyl of 1 through 18 and hydrogen: R is selected from the group consisting of hydrogen, lower-alkyl, phenyl, benzyl, cyclopropyl, lower-alkoxylower-alkyl, and lower-alkylthiolower-alkyl; and pharmaceutically acceptable salts thereof.
Claim 5
Dependent Claim
86 words
A compound of the formula: ##STR13## wherein R is selected from the group consisting of hydrogen, lower alkyl of 1 through 4 carbon atoms and cyclopropyl; R' is selected from the group consisting of hydrogen and lower alkyl of 1 through 4 carbon atoms; Y is selected from the group consisting of hydrogen, carboxacyl of from 1 through 18 carbon atoms, and phosphono; Y' is selected from the group consisting of carboxacyl of from 1 through 18 carbon atoms and hydrogen; and pharmaceutically acceptable salts thereof.
Claim 6
Dependent Claim
86 words
A compound of the formula: ##STR13## wherein R is selected from the group consisting of hydrogen, lower alkyl of 1 through 4 carbon atoms and cyclopropyl; R' is selected from the group consisting of hydrogen and lower alkyl of 1 through 4 carbon atoms; Y is selected from the group consisting of hydrogen, carboxacyl of from 1 through 18 carbon atoms, and phosphono; Y' is selected from the group consisting of carboxacyl of from 1 through 18 carbon atoms and hydrogen; and pharmaceutically acceptable salts thereof.
Claim 7
Dependent Claim
10 words
A compound according to claim 3 wherein R' is hydrogen.
Claim 8
Dependent Claim
12 words
A compound according to claim 3 wherein Y and Y' are hydrogen.
Claim 9
Dependent Claim
13 words
A compound according to claim 3 wherein Y, Y' and R' are hydrogen.
Claim 10
Dependent Claim
23 words
A compound according to claim 3 wherein Y and Y' are carboxacyl of from 1 through 18 carbon atoms and R' is hydrogen.
Claim 11
Dependent Claim
23 words
A compound according to claim 3 wherein Y is carboxacyl of from 1 through 18 carbon atoms, and Y' and R' are hydrogen.
Claim 12
Dependent Claim
23 words
A compound according to claim 3 wherein Y' is carboxacyl of from 1 through 18 carbon atoms; and Y and R' are hydrogen.
Claim 13
Dependent Claim
87 words
A compound of the formula ##STR14## wherein R is selected from the group consisting of hydrogen, lower alkyl of 1 through 4 carbon atoms, and cyclopropyl; R' is selected from the group consisting of hydrogen and lower alkyl of 1 through 4 carbon atoms; Y is selected from the group consisting of hydrogen, carboxacyl of from 1 through 18 carbon atoms, and phosphono; and Y' is selected from the group consisting of carboxacyl of from 1 through 18 carbon atoms and hydrogen; and pharmaceutically acceptable salts thereof.
Claim 14
Dependent Claim
87 words
A compound of the formula ##STR14## wherein R is selected from the group consisting of hydrogen, lower alkyl of 1 through 4 carbon atoms, and cyclopropyl; R' is selected from the group consisting of hydrogen and lower alkyl of 1 through 4 carbon atoms; Y is selected from the group consisting of hydrogen, carboxacyl of from 1 through 18 carbon atoms, and phosphono; and Y' is selected from the group consisting of carboxacyl of from 1 through 18 carbon atoms and hydrogen; and pharmaceutically acceptable salts thereof.
Claim 15
Dependent Claim
10 words
A compound according to claim 10 wherein R' is hydrogen.
Claim 16
Dependent Claim
12 words
A compound according to claim 10 wherein Y and Y' are hydrogen.
Claim 17
Dependent Claim
13 words
A compound according to claim 10 wherein Y, Y' and R' are hydrogen.
Claim 18
Dependent Claim
23 words
A compound according to claim 10 wherein Y and Y' are carboxacyl of from 1 through 18 carbon atoms and R' is hydrogen.
Claim 19
Dependent Claim
23 words
A compound according to claim 10 wherein Y is carboxacyl of from 1 through 18 carbon atoms, and Y' and R' are hydrogen
Claim 20
Dependent Claim
23 words
A compound according to claim 10 wherein Y' is carboxacyl of from 1 through 18 carbon atoms; and Y and R' are hydrogen.
Claim 21
Dependent Claim
1 words
1-(2-Deoxy-β-D-ribofuranosyl)-5-ethyl-5,6-dihydro-s-triazine-2,4-(1H,3H)-dione.
Claim 22
Dependent Claim
1 words
1-(2-Deoxy-β-D-ribofuranosyl)-5-ethyl-5,6-dihydro-s-triazine-2,4-(1H,3H)-dione.
Claim 23
Dependent Claim
1 words
1-(2-Deoxy-β-D-ribofuranosyl)-5-n-butyl-5,6-dihydro-s-triazine-2,4-(1H,3H)-dione.
Claim 24
Dependent Claim
1 words
1-(2-Deoxy-β-D-ribofuranosyl)-5-n-butyl-5,6-dihydro-s-triazine-2,4-(1H,3H)-dione.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-10-15 | 1983-04-16 | 1983-10-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-10-15 | 1987-04-16 | 1987-10-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-10-15 | 1991-04-16 | 1991-10-16 | $7700.00 | Window Closed / Lapsed |