Process for the preparation of pyrimidine nucleosides
Abstract
Abstract AN IMPROVED PROCESS FOR PRODUCING PYRIMIDINE NUCLEOSIDES OF THE FORMULA Z-N<(-Y=C(-R)-C(=X)-NH-C(=W)-) WHEREIN R AND Y HAVE THE VALUES GIVEN ABOVE, D IS A SILYL OR ALKYL ETHER GROUP OR A GROUP OF THE FORMULA (ALKYL) SI-NB OR ALKYL-NB WHEREIN B HAS THE VALUE GIVEN ABOVE, USING SNCL4, TICL4, ZNCL2, BF3 (ETHERATE), ALCL3 OR FECL3 AS THE REACTION CATALYST. Y<(=C(-R)-C(-D)=N-C(-E)=N-) WHEREIN R IS H, LOWER-ALKYL, -NO2 OR C$N, W IS O OR S, X IS O OR =N-B IN WHICH B IS H, ALKYL, ARYL, OR ARALKYL AND Z IS A MASKED SUGAR RESIDUE, HAVING CYTOTOXIC, ANTIVIRAL, ENZYME-INHIBITING, IMMUNOSUPPRESSIVE, ANTI-INFLAMMATORY AND ANTI-PSORIATIC ACTIVITY, BY REACTING A 1-O-ACYL, 1-O-ALKYL OR 1-HALO SUGAR WHOSE FREE HYDROXY GROUPS ARE BLOCKED BY ETHER AND/OR ESTER GROUPS WITH A PYRIMIDINE DERIVATIVE OF THE FORMULA
Inventors
- 👤 H Vorbrueggen
- 👤 U Niedballa
Bibliographic Details
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