US4171370A
Expired / Lapsed
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Phenoxy-amino-propanols
Assignee: Merck Patent GmbH
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Filing: 1977-10-04
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Granted: 1979-10-16
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Expires: 1997-10-04
Abstract
Abstract New phenoxy-amino-propanols of formula ##STR1## wherein R 1 is alkenyl, alkynyl, alkoxyalkyl or alkenyloxyalkyl with 2-6 C atoms in each case or cycloalkyl with 3-8 C atoms; and R 2 is alkyl or hydroxyalkyl with 1-6 C atoms in each case, cycloalkyl with 3-8 C atoms, aralkyl or aralkyl wherein the aryl radical is mono- to tri-substituted by alkyl, alkoxy, OH, F and/or Cl or mono-substituted by methylenedioxy, with a total of 7-15 C atoms in each case, and the physiologically acceptable acid addition salts thereof, exhibit various pharmacological properties including isoprenaline-antagonism on the heart rate and blood pressure.
Inventors
- 👤 Rochus Jonas
- 👤 Karl-Heinz Becker
- 👤 Hans-Joachim Enenkel
- 👤 Klaus Minck
- 👤 Hans-Jochen Schliep
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:19
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K31/138; C; C07; C07C; C07C217/00; C07C217/02; C07C217/04; C07C217/28; C07C217/30; C07C217/32; C07C217/78; C07C217/80; C07D; C07D303/00; C07D303/02; C07D303/12; C07D303/18; C07D303/20; C07D303/24; C07D317/00; C07D317/08; C07D317/44; C07D317/46; C07D317/48; C07D317/50; C07D317/58
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
54 words
Phenoxy-amino-propanols of the formula ##STR4## wherein R 1 is alkenyl, alkynyl, alkoxyalkyl, alkenyloxyalkyl, with 2-6 C atoms in each case, or cycloalkyl with 3-8 C atoms; and R 2 is aralkyl wherein the aryl radical is monosubstituted by methylenedioxy, with a total of 7-15 C atoms, and the physiologically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
54 words
Phenoxy-amino-propanols of the formula ##STR4## wherein R 1 is alkenyl, alkynyl, alkoxyalkyl, alkenyloxyalkyl, with 2-6 C atoms in each case, or cycloalkyl with 3-8 C atoms; and R 2 is aralkyl wherein the aryl radical is monosubstituted by methylenedioxy, with a total of 7-15 C atoms, and the physiologically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
29 words
A pharmaceutical composition which comprises an amount of a compound of claim 1 effective for achieving isoprenaline-antagonism on the heart rate or blood pressure, and a pharmaceutically acceptable adjuvant.
Claim 4
Dependent Claim
42 words
A method of achieving isoprenaline-antagonism on the heart rate or blood pressure in a mammal, which comprises administering to a mammal an amount of a compound of claim 1 which is effective for achieving isoprenaline-antagonism on the heart rate or blood pressure.
Claim 5
Dependent Claim
6 words
1-(o-2-Methoxyethoxymethyl-phenoxy)-3-[2-(3,4-methylenedioxyphenyl)-ethylamino]-propan-2-ol, a compound of claim 1.
Claim 6
Dependent Claim
29 words
A pharmaceutical composition which comprises an amount of a compound of claim 4 effective for achieving isoprenaline-antagonism on the heart rate or blood pressure, and a pharmaceutically acceptable adjuvant.
Claim 7
Dependent Claim
42 words
A method of achieving isoprenaline-antagonism on the heart rate or blood pressure in a mammal, which comprises administering to a mammal an amount of a compound of claim 4 which is effective for achieving isoprenaline-antagonism on the heart rate or blood pressure.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-10-15 | 1983-04-16 | 1983-10-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-10-15 | 1987-04-16 | 1987-10-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-10-15 | 1991-04-16 | 1991-10-16 | $7700.00 | Window Closed / Lapsed |