US4067904A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Alkylsulfonylphenoxypropanolamine derivatives
Assignee: Mead Johnson and Co LLC
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Filing: 1976-09-10
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Granted: 1978-01-10
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Expires: 1996-09-10
Abstract
Abstract A new class of phenoxypropanolamine alkylsulfonyl derivatives and methods for their preparation are described. The new compounds possess antiarrhythmic and/or cardioselective β-adrenergic blocking properties and are useful in the treatment of hypertension. Representative embodiments of the invention are 1-(isopropylamino)-3-[4-(methylsulfonyl)-m-tolyloxy]-2-propanol and 3-[4-(methylsulfonyl)-m-tolyloxy]-1-(1-phenoxy-2-propylamino)-2-propanol, the latter compound is particularly outstanding as an antihypertensive.
Inventors
- 👤 William T. Comer
- 👤 William E. Kreighbaum
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 12:25
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/18
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
18 words
A compound selected from the group consisting of 1-(phenoxyisopropylamino)-3-[4-(methylsulfonyl)-m-tolyloxy]-2-propanol or a pharmaceutically acceptable non-toxic acid addition salt thereof.
Claim 2
Dependent Claim
18 words
A compound selected from the group consisting of 1-(phenoxyisopropylamino)-3-[4-(methylsulfonyl)-m-tolyloxy]-2-propanol or a pharmaceutically acceptable non-toxic acid addition salt thereof.
Claim 3
Dependent Claim
18 words
A compound selected from the group consisting of 1-(isopropylamino)-3-[2-(methylsulfonyl)phenoxy]-2-propanol or a pharmaceutically acceptable non-toxic acid addition salt thereof.
Claim 4
Dependent Claim
18 words
A compound selected from the group consisting of 1-(isopropylamino)-3-[2-(methylsulfonyl)phenoxy]-2-propanol or a pharmaceutically acceptable non-toxic acid addition salt thereof.
Claim 5
Dependent Claim
18 words
A compound selected from the group consisting of 1-[(4-methoxy-α,α-dimethylphenethyl)amino]-3-[4-(methylsulfonyl)-m-tolyloxy]-2-propanol or a pharmaceutically acceptable non-toxic acid addition salt thereof.
Claim 6
Dependent Claim
18 words
A compound selected from the group consisting of 1-[(4-methoxy-α,α-dimethylphenethyl)amino]-3-[4-(methylsulfonyl)-m-tolyloxy]-2-propanol or a pharmaceutically acceptable non-toxic acid addition salt thereof.
Claim 7
Dependent Claim
17 words
A compound selected from the group consisting of 3-[4-(methylsulfonyl)-m-tolyloxy]-1-(2-phenoxyethyl)amino-2-propanol or a pharmaceutically acceptable acid addition salt thereof.
Claim 8
Dependent Claim
17 words
A compound selected from the group consisting of 3-[4-(methylsulfonyl)-m-tolyloxy]-1-(2-phenoxyethyl)amino-2-propanol or a pharmaceutically acceptable acid addition salt thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-01-09 | 1981-07-11 | 1982-01-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-01-09 | 1985-07-11 | 1986-01-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-01-09 | 1989-07-11 | 1990-01-10 | $7700.00 | Window Closed / Lapsed |