Process for the production of substituted pyridine (b)

Claim 1

A process for the production of a pyridine having a substituent from the group consisting of an aromatic group and a heteroaromatic group in each of the 2-and 3-position which comprises catalytically reacting a ketone having an aromatic or heteroaromatic group on both sides of the keto group and also having at least one reactive methylene group adjacent to the keto group with an aliphatic oxo compound having a carbon to carbon ethylenic double bond on the carbon atom adjacent to the oxo group and ammona in the gas phase at a temperature from about 250° to 500° C. in the presence of a dehydrating and dehydrogenating catalyst which is either (1) a catalyst consisting essentially of oxygen containing compounds of Al,F, at least one of the elements B and Si and at least one element from the second and fourth groups of the periodic system selected from the group consisting of Mg,Ba,Zn,Sn and Zr, said catalyst having been prepared by heating in the presence of oxygen at a temperature of 600° to 800° C.: 1. aluminum, aluminum oxide or an aluminum compound convertible to the oxide at said temperature, 2. a compound of fluorine, said fluorine having been added as ammonium fluoride, ammonium hydrogen fluoride, hydrogen fluoride, fluoboric acid, fluosilicic acid, boron trifluoride, magnesium fluoborate, magnesium fluosilicate, zinc fluosilicate or barium fluosilicate, 3. boron, silicon, boric oxide, silica or a compound of boron or silicon convertible to the oxide at said temperature and 4. magnesium, zinc, tin, zirconium, magnesium oxide, zinc oxide, tin oxide or a compound of zirconium or barium convertible to the oxide at said temperature, the atomic ratio of Al to F being from 1000:25 to 1000:800 and the atomic ratio of Al to the total of (3) and (4) being from 1000:5 to 1000:200, the atomic ratio of the total of boron and silicon to the other element from the second and fourth group being between 1 to 10 and 10 to 1, (2) a catalyst having been prepared by heating at 600° to 800° C. in the presence of gaseous oxygen (1) aluminum metal, aluminum oxide or a compound of aluminum convertible to the oxide upon heating with gaseous oxygen at 600° C. to 800° C., (2) ammonium fluoride, hydrogen fluoride or a fluoride of an element of the second main group of the periodic system and (3) at least one element of the second main group of the periodic system, the oxide of said element or a compound of said element convertible to the oxide in the presence of gaseous oxygen at a temperature of 600° to 800° C., said catalyst consisting essentially of the elements Al, F, O and the element of the second main group of the periodic system being selected from the group consisting of Mg, Ca, Sr and Ba, and (3) a catalyst consisting essentially of the product obtained by treating with oxygen at a temperature of 550° to 1200° C., compounds of the elements Al, F and O and at least two other elements selected from the second, fourth, fifth and sixth groups of the periodic system, said two other elements being selected from the group consisting of Mg, Ba, Zr, Sn, Ti, P, Ta, Sb and S, the ratios of the elements being Al to F of between 1,000 to 10 and 1,000 to 800 and of Al to the elements of the second, fourth, fifth and sixth groups being between 1,000 to 5 and 1,000 to 200.