Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
420 words
A guanidine derivative of the formula: ##STR24## in which X is a sulphur atom or NH radical; Y is an oxygen or sulphur atom or a sulphinyl radical; m is 1 to 4 and n is 1 to 4, provided that when Y is an oxygen atom or a sulphinyl radical n is 2 to 4; R 1 is a hydrogen or halogen atom or an alkyl radical of 1 to 6 carbon atoms; R 2 is a hydrogen atom, an alkyl radical of 1 to 10 carbon atoms, an alkanoyl radical of 1 to 6 carbon atoms or an aroyl radical of 7 to 11 carbon atoms; A is a 3,4-dioxocyclobuten-1,2-diyl radical or a radical of the formula C═Z in which Z is an oxygen or sulphur atom or a radical of the formula NCN, NNO 2 , CHNO 2 , NCONH 2 , C(CN) 2 , NCOR 3 , NCO 2 R 3 , NSO 2 R 3 or NR 4 in which R 3 is an alkyl radical of 1 to 6 carbon atoms or an aryl radical of 6 to 12 carbon atoms and R 4 is a hydrogen atom or an alkyl radical of 1 to 6 carbon atoms; B is an alkoxy or alkylthio radical of 1 to 6 carbon atoms or a radical of the formula NR 5 R 6 in which R 5 and R 6 , which may be the same or different, are hydrogen atoms, alkyl radicals of 1 to 10 carbon atoms, alkenyl radicals of 3 to 10 carbon atoms in which the double bond is separated from the nitrogen atom of NR 5 R 6 by at least one carbon atom, cycloalkyl radicals of 3 to 8 carbon atoms, (primary hydroxy)alkyl radicals of 2 to 6 carbon atoms in which the oxygen atom is separated from the nitrogen atom of NR 5 R 6 by at least two carbon atoms, alkoxyalkyl radicals of 3 to 10 carbon atoms in which the oxygen atom is separated from the nitrogen atom of NR 5 R 6 by at least two carbon atoms, alkylaminoalkyl radicals of 3 to 10 carbon atoms in which the nitrogen atom is separated from the nitrogen atom of NR 5 R 6 by at least two carbon atoms; or dialkylaminoalkyl radicals of 4 to 10 carbon atoms in which the nitrogen atom is separated from the nitrogen atom of NR 5 R 6 by at least two carbon atoms; and the pharmaceutically acceptable acid-addition salts thereof.
Claim 2
Dependent Claim
420 words
A guanidine derivative of the formula: ##STR24## in which X is a sulphur atom or NH radical; Y is an oxygen or sulphur atom or a sulphinyl radical; m is 1 to 4 and n is 1 to 4, provided that when Y is an oxygen atom or a sulphinyl radical n is 2 to 4; R 1 is a hydrogen or halogen atom or an alkyl radical of 1 to 6 carbon atoms; R 2 is a hydrogen atom, an alkyl radical of 1 to 10 carbon atoms, an alkanoyl radical of 1 to 6 carbon atoms or an aroyl radical of 7 to 11 carbon atoms; A is a 3,4-dioxocyclobuten-1,2-diyl radical or a radical of the formula C═Z in which Z is an oxygen or sulphur atom or a radical of the formula NCN, NNO 2 , CHNO 2 , NCONH 2 , C(CN) 2 , NCOR 3 , NCO 2 R 3 , NSO 2 R 3 or NR 4 in which R 3 is an alkyl radical of 1 to 6 carbon atoms or an aryl radical of 6 to 12 carbon atoms and R 4 is a hydrogen atom or an alkyl radical of 1 to 6 carbon atoms; B is an alkoxy or alkylthio radical of 1 to 6 carbon atoms or a radical of the formula NR 5 R 6 in which R 5 and R 6 , which may be the same or different, are hydrogen atoms, alkyl radicals of 1 to 10 carbon atoms, alkenyl radicals of 3 to 10 carbon atoms in which the double bond is separated from the nitrogen atom of NR 5 R 6 by at least one carbon atom, cycloalkyl radicals of 3 to 8 carbon atoms, (primary hydroxy)alkyl radicals of 2 to 6 carbon atoms in which the oxygen atom is separated from the nitrogen atom of NR 5 R 6 by at least two carbon atoms, alkoxyalkyl radicals of 3 to 10 carbon atoms in which the oxygen atom is separated from the nitrogen atom of NR 5 R 6 by at least two carbon atoms, alkylaminoalkyl radicals of 3 to 10 carbon atoms in which the nitrogen atom is separated from the nitrogen atom of NR 5 R 6 by at least two carbon atoms; or dialkylaminoalkyl radicals of 4 to 10 carbon atoms in which the nitrogen atom is separated from the nitrogen atom of NR 5 R 6 by at least two carbon atoms; and the pharmaceutically acceptable acid-addition salts thereof.
Claim 3
Dependent Claim
172 words
A compound of claim 1 wherein X is a sulphur atom or an NH radical; Y is a sulphur atom or a sulphinyl radical; m is 1 to 4 and n is 1 to 4, provided that when Y is a sulphinyl radical n is 2 to 4; R 1 is a hydrogen or bromine atom or methyl radical; R 2 is a hydrogen atom, or a methyl, n-butyl, acetyl, propionyl or benzoyl radical; A is a 3,4-dioxocyclobuten-1,2-diyl radical or a radical of the formula C═Z in which Z is an oxygen or sulphur atom or a radical of the formula NCN, NNO 2 , CHNO 2 , NCONH 2 , C(CN) 2 , NCO 2 CH 3 , NSO 2 -p-tolyl or NCH 3 ; B is a methoxy, ethoxy or methylthio radical or a radical of the formula NR 5 R 6 in which R 5 and R 6 are independently selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-hexyl, allyl, cyclohexyl, 2-hydroxyethyl, 3-hydroxypropyl, 2-methoxyethyl and 2-dimethylaminoethyl radicals.
Claim 4
Dependent Claim
11 words
A compound of claim 1 wherein X is a sulphur atom.
Claim 5
Dependent Claim
11 words
A compound of claim 3 wherein Y is a sulphur atom.
Claim 6
Dependent Claim
12 words
A compound of claim 4 wherein R 1 is a hydrogen atom.
Claim 7
Dependent Claim
12 words
A compound of claim 5 were R 2 is a hydrogen atom.
Claim 8
Dependent Claim
13 words
A compound of claim 6 where A is C═Z wherein Z is NCN.
Claim 9
Dependent Claim
22 words
A compound of claim 7 where B is NR 5 R 6 wherein R 5 is methyl and R 6 is methyl.
Claim 10
Dependent Claim
121 words
A compound of claim 1 where X is a sulphur atom; Y is a sulphur atom; m is 1 to 4; n is 1 to 4; R 1 is a hydrogen atom; R 2 is a hydrogen atom or a methyl rdical; A is C═Z wherein Z is a sulphur atom or a radical of the formula NCN, NNO 2 , NCONH 2 , NCOR 3 , NCO 2 R 3 or NSO 2 R 3 in which R 3 is a phenyl radical; and B is a radical of the formula NR 4 R 5 wherein R 4 and R 5 are independently selected from the group consisting of hydrogen and lower alkyl radicals of 1 to 4 carbon atoms.
Claim 11
Dependent Claim
87 words
A compound of claim 1 where X is a sulphur atom; Y is a sulphur atom; m is 1 to 4; n is 1 to 4; R 1 is hydrogen; R 2 is hydrogen; A is C═Z where Z is a sulphur atom or a radical of the formul NCN; and B is a radical of the formula NR 4 R 5 wherein R 4 and R 5 are independently selected from the group consisting of hydrogen and lower alkyl radicals of 1 to 4 carbon atoms.
Claim 12
Dependent Claim
15 words
A compound of claim 4 where m is 1 and n is 1 to 2.
Claim 13
Dependent Claim
8 words
A compound of claim 1 which is 2-quanidino-4-[2-(2-cyano-3-ethylguanidino)ethylthiomethyl]thiazole.
Claim 14
Dependent Claim
8 words
A compound of claim 1 which is 2-guanidino-4-[2-(2-cyano-3-methylguanidino)ethylthiomethyl]thiazole.
Claim 15
Dependent Claim
8 words
A compound of claim 1 which is 2-guanidino-4-[2-(2-nitroguanidino)ethylthiomethyl]thiazole.
Claim 16
Dependent Claim
8 words
A compound of claim 1 which is 2-guanidino-4-[2-(2-cyanoguanidino)ethylthiomethyl]thiazole.
Claim 17
Dependent Claim
8 words
A compound of claim 1 which is 2-guanidino-4-[2-(2-cyano-3-(2-hydroxyethyl)guanidino)ethylthiomethyl]thiazole.
Claim 18
Dependent Claim
27 words
A pharmaceutical composition to inhibit gastric acid secretion comprising a therapeutically effective amount of a compound of claim 1 to inhibit said secretion in a pharmaceutical carrier.
Claim 19
Dependent Claim
27 words
A pharmaceutical composition to inhibit gastric acid secretion comprising a therapeutically effective amount of a compound of claim 13 to inhibit said secretion in a pharmaceutical carrier.
Claim 20
Dependent Claim
21 words
A method of inhibiting gastric acid secretion in a living animal comprising administering to the animal a composition of claim 17.