US4164495A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of recovering immunoglobulin using a polyol and an alkanoic acid
Assignee: Nordisk Insulinlaboratorium
•
Filing: 1978-06-12
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Granted: 1979-08-14
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Expires: 1998-06-12
Abstract
Abstract Immunoglobulins or gammaglobulins are recovered in a pure and anticomplementary condition by fractionated precipitation of blood plasma with a polycondensed di or polyol, such as PEG, in the presence of a mono or polyalkanoic acid having 4 to 12 carbon atoms, such as caprylic acid.
Inventors
- 👤 Jorgen F. Hansen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 20:09
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/06; C07K16/065; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
55 words
A method of recovering purified immunoglobulin suitable for intravenous administration wherein blood plasma, serum or a fraction thereof is subjected to a fractionated precipitation using a combination of polycondensed polyol and a mono or polyalkanoic acid having from 4 to 12 carbon atoms as a precipitant, the fractionating process being performed at approximately room temperature.
Claim 2
Independent Claim
55 words
A method of recovering purified immunoglobulin suitable for intravenous administration wherein blood plasma, serum or a fraction thereof is subjected to a fractionated precipitation using a combination of polycondensed polyol and a mono or polyalkanoic acid having from 4 to 12 carbon atoms as a precipitant, the fractionating process being performed at approximately room temperature.
Claim 3
Dependent Claim
25 words
A method according to claim 1, characterized in that the mono or polyalkanoic acid is an alkanoic acid having from 6 to 9 carbon atoms.
Claim 4
Dependent Claim
25 words
A method according to claim 1 or claim 2, characterized by effecting the precipitation with alkanoic acid at a pH of from 3 to 7.
Claim 5
Dependent Claim
12 words
A process according to claim 1 wherein the polyol is a diol.
Claim 6
Dependent Claim
14 words
A method according to claim 3 wherein the pH is from 4.5 to 5.5.
Claim 7
Dependent Claim
13 words
A method according to claim 2 wherein the alkanoic acid is caprylic acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-08-13 | 1983-02-12 | 1983-08-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-08-13 | 1987-02-12 | 1987-08-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-08-13 | 1991-02-12 | 1991-08-14 | $7700.00 | Window Closed / Lapsed |