Patent US4154961A successfully refreshed from Google Patents.
US4154961A
Expired / Lapsed
US
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Oxamic acid derivatives
Assignee: Wyeth LLC
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Filing: 1977-09-19
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Granted: 1979-05-15
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Expires: 1997-09-19
Abstract
Abstract Anti-allergic agents of aromatic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of α-naphthyl, β-naphthyl, phenyl, 2,6-di-chlorophenyl, and substituted phenyl moieties containing from one to three substituents in any of the 2,3,4 and 5 positions of the phenyl ring, independently selected from the group consisting of lower alkyl, lower alkylthio, lower alkylsulfinyl, lower alkoxy, hydroxy (lower)alkoxy, 2-(oxalyloxy) ethoxy, benzyloxy, N-mono- and di-lower alkylamino(lower)alkoxy, halo, sulfamyl, polyhalo(lower)alkyl, carbamyl, N-lower alkylcarbamyl, nitro, mono and di lower alkylamino, carboxy, lower alkylcarbonyl, carb(lower)alkoxy, phenoxy(lower)alkoxy, and oxalamidophenoxy radicals; And pharmaceutically acceptable salts thereof.
Inventors
- 👤 John H. Sellstedt
- 👤 Charles J. Guinosso
- 👤 Albert J. Begany
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 17:13
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/72; C07D213/75; C07C; C07C245/00; C07C245/02; C07C245/06; C07C245/08; C07D239/00; C07D239/02; C07D239/24; C07D239/26; C07D257/00; C07D257/02; C07D257/04
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
72 words
A compound of the formula: ##STR6## wherein R 1 is lower alkylamino or amino; R 2 is hydrogen, lower alkoxy, hydroxy (lower) alkoxy, halo or 2-(oxalyloxy)ethoxy; R 3 is hydrogen, lower alkyl, lower alkoxy, halo or nitro; and R 4 is hydrogen, lower alkyl or lower alkoxy; with the proviso that one of R 2 , R 3 and R 4 must be other than hydrogen, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
72 words
A compound of the formula: ##STR6## wherein R 1 is lower alkylamino or amino; R 2 is hydrogen, lower alkoxy, hydroxy (lower) alkoxy, halo or 2-(oxalyloxy)ethoxy; R 3 is hydrogen, lower alkyl, lower alkoxy, halo or nitro; and R 4 is hydrogen, lower alkyl or lower alkoxy; with the proviso that one of R 2 , R 3 and R 4 must be other than hydrogen, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
15 words
The compound of claim 1 which is 2'-carbamyl-3'-methoxyoxanilic acid or a pharamceutically acceptable salt thereof.
Claim 4
Dependent Claim
15 words
The compound of claim 1 which is 2'-carbamyl-3'-chlorooxanilic acid or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
15 words
The compound of claim 1 which is 2'-carbamyl-4'-chlorooxanilic acid or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
15 words
The compound of claim 1 which is 2'-carbamyl-4'-nitrooxanilic acid or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
15 words
The compound of claim 1 which is 2'-carbamyl-5'-methoxyoxanilic acid or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
15 words
The compound of claim 1 which is 2'-carbamyl-3'-ethoxyoxanilic acid or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
15 words
The compound of claim 1 which is 2'-carbamyl-3'-propoxyoxanilic acid or a pharmaceutically acceptable salt thereof.
Claim 10
Dependent Claim
15 words
The compound of claim 1 which is 2'-carbamyl-3'-isopropoxyoxanilic acid or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
15 words
The compound of claim 1 which is 2'-carbamyl-3'-n-butoxyoxanilic acid or a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
15 words
The compound of claim 1 which is 3'-methoxy-2'-N-methylcarbamyloxanilic acid or a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
15 words
The compound of claim 1 which is (2-carbamyl-4,5-dimethylphenyl)oxamic acid or a pharmaceutically acceptable salt thereof.
Claim 14
Dependent Claim
15 words
The compound of claim 1 which is 2'-carbamyl-3'-(2-hydroxypropoxy)oxanilic acid or a pharmaceutically acceptable salt thereof.
Claim 15
Dependent Claim
15 words
The compound of claim 1 which is (2-carbamyl-3,5-dimethoxyphenyl)oxamic acid or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-14 | 1982-11-13 | 1983-05-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-14 | 1986-11-13 | 1987-05-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-14 | 1990-11-13 | 1991-05-15 | $7700.00 | Window Closed / Lapsed |