US4017538A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Alkyl thio sulfinyl and sulfonyl oxamic compounds, compositions and methods of use
Assignee: Pharmacia and Upjohn Co
•
Filing: 1975-10-01
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Granted: 1977-04-12
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Expires: 1995-10-01
Abstract
Abstract It has now been discovered that novel compounds of the figure below and their pharmaceutical compositions are useful in the prophylactic treatment of sensitized humans and animals for allergy and anaphylactic reactions of a reagin or non-reagin mediated nature. ##STR1##
Inventors
- 👤 Charles M. Hall
- 👤 John B. Wright
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 09:47
CPC Classifications
C; C07; C07C; C07C323/00
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
110 words
A compound of the formula ##STR72##wherein X is at the 3 or 4 position and is hydrogen or ##STR73##Y is selected from the group consisting of hydrogen, alkyl of one to four carbon atoms, inclusive, halo, hydroxy, cyano, nitro, trifluoromethyl, ##STR74## wherein D is selected from the group consisting of hydrogen, and a physiologically acceptable metal or amine cation, R is selected from the group consisting of hydrogen, and a physiologically acceptable metal or amine cation; R 1 is selected from the group consisting of hydrogen, alkyl of one to six carbon atoms, inclusive, and cycloalkyl of five or six carbon atoms, inclusive; and n is 0, 1 or 2.
Claim 2
Dependent Claim
110 words
A compound of the formula ##STR72##wherein X is at the 3 or 4 position and is hydrogen or ##STR73##Y is selected from the group consisting of hydrogen, alkyl of one to four carbon atoms, inclusive, halo, hydroxy, cyano, nitro, trifluoromethyl, ##STR74## wherein D is selected from the group consisting of hydrogen, and a physiologically acceptable metal or amine cation, R is selected from the group consisting of hydrogen, and a physiologically acceptable metal or amine cation; R 1 is selected from the group consisting of hydrogen, alkyl of one to six carbon atoms, inclusive, and cycloalkyl of five or six carbon atoms, inclusive; and n is 0, 1 or 2.
Claim 3
Dependent Claim
48 words
A compound in accordance with claim 1 wherein Y is selected from the group consisting of hydrogen, alkyl of one to three carbon atoms, inclusive, halo, hydroxy, cyano, nitro, trifluoromethyl, ##STR75##wherein D is selected from the group consisting of hydrogen, and a physiologically acceptable metal or amine cation.
Claim 4
Dependent Claim
58 words
A compound in accordance with claim 2 wherein X is at the 3 position; Y is selected from the group consisting of hydrogen, alkyl of one to three carbon atoms, inclusive, fluoro, chloro, bromo, cyano, trifluoromethyl, and ##STR76## and R 1 is selected from the group consisting of hydrogen and alkyl of one to four carbon atoms, inclusive.
Claim 5
Dependent Claim
45 words
A compound in accordance with claim 3 wherein Y is at the 2 or 5 position; R 1 s(o) n is at the 2 or 5 position; and R is selected from the group consisting of hydrogen, and a physiologically acceptable metal or amine cation.
Claim 6
Dependent Claim
11 words
A compound in accordance with claim 4 wherein n is zero.
Claim 7
Dependent Claim
11 words
A compound in accordance with claim 4 wherein n is one.
Claim 8
Dependent Claim
11 words
A compound in accordance with claim 4 wherein n is two.
Claim 9
Dependent Claim
6 words
3'-(methylsulfinyl)oxanilic acid according to claim 1.
Claim 10
Dependent Claim
6 words
3'-(methylsulfonyl)oxanilic acid according to claim 1.
Claim 11
Dependent Claim
134 words
A pharmaceutical composition which comprises an anti-allergy effective amount of a compound of the formula ##STR77##wherein X is at the 3 or 4 position and is hydrogen or ##STR78##Y is selected from the group consisting of hydrogen, alkyl of one to four carbon atoms, inclusive, halo, hydroxy, cyano, nitro, trifluoromethyl, ##STR79## wherein D is selected from the group consisting of hydrogen, and a physiologically acceptable metal or amine cation, R is selected from the group consisting of hydrogen, ##STR80## wherein m is 0, 1 or 2, and a physiologically acceptable metal or amine cation; R 1 is selected from the group consisting of hydrogen, alkyl of one to six carbon atoms, inclusive, and cycloalkyl of five or six carbon atoms, inclusive; and n is 0, 1 or 2, in association with a pharmaceutical carrier.
Claim 12
Dependent Claim
134 words
A pharmaceutical composition which comprises an anti-allergy effective amount of a compound of the formula ##STR77##wherein X is at the 3 or 4 position and is hydrogen or ##STR78##Y is selected from the group consisting of hydrogen, alkyl of one to four carbon atoms, inclusive, halo, hydroxy, cyano, nitro, trifluoromethyl, ##STR79## wherein D is selected from the group consisting of hydrogen, and a physiologically acceptable metal or amine cation, R is selected from the group consisting of hydrogen, ##STR80## wherein m is 0, 1 or 2, and a physiologically acceptable metal or amine cation; R 1 is selected from the group consisting of hydrogen, alkyl of one to six carbon atoms, inclusive, and cycloalkyl of five or six carbon atoms, inclusive; and n is 0, 1 or 2, in association with a pharmaceutical carrier.
Claim 13
Independent Claim
136 words
A method of prophylactically treating allergy of a reagin or non-reagin mediated nature in a mammal which comprises the administration of an anti-allergy effective amount of a compound of the formula ##STR81##wherein X is at the 3 or 4 position and is hydrogen or ##STR82##Y is selected from the group consisting of hydrogen, alkyl of one to four carbon atoms, inclusive, halo, hydroxy, cyano, nitro, trifluoromethyl, ##STR83## wherein D is selected from the group consisting of hydrogen, and a physiologically acceptable metal or amine cation, R is selected from the group consisting of hydrogen, and a physiologically acceptable metal or amine cation; R 1 is selected from the group consisting of hydrogen, alkyl of one to six carbon atoms, inclusive, and cycloalkyl of five or six carbon atoms, inclusive; and n is 0, 1 or 2.
Claim 14
Independent Claim
136 words
A method of prophylactically treating allergy of a reagin or non-reagin mediated nature in a mammal which comprises the administration of an anti-allergy effective amount of a compound of the formula ##STR81##wherein X is at the 3 or 4 position and is hydrogen or ##STR82##Y is selected from the group consisting of hydrogen, alkyl of one to four carbon atoms, inclusive, halo, hydroxy, cyano, nitro, trifluoromethyl, ##STR83## wherein D is selected from the group consisting of hydrogen, and a physiologically acceptable metal or amine cation, R is selected from the group consisting of hydrogen, and a physiologically acceptable metal or amine cation; R 1 is selected from the group consisting of hydrogen, alkyl of one to six carbon atoms, inclusive, and cycloalkyl of five or six carbon atoms, inclusive; and n is 0, 1 or 2.
Claim 15
Dependent Claim
17 words
A method in accordance with claim 11 wherein the compound is in association with a pharmaceutical carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-04-11 | 1980-10-11 | 1981-04-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-04-11 | 1984-10-11 | 1985-04-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-04-11 | 1988-10-11 | 1989-04-12 | $7700.00 | Window Closed / Lapsed |