Patent US4151185A successfully refreshed from Google Patents.
US4151185A
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Complex or salt of a platinum (II) compound and a nitrogen containing polymer
Assignee: Pennsylvania Research Corp
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Filing: 1977-05-02
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Granted: 1979-04-24
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Expires: 1997-05-02
Abstract
Abstract A cis- complex or -salt of a square planar platinum compound and a nitrogen containing oligomer or polymer prepared by reacting a platinum (II) compound with a nitrogen containing oligomer or polymer in an organic solvent or an acidic aqueous medium, said complex or salt being useful as an anti-cancer agent.
Inventors
- 👤 Harry R. Allcock
- 👤 Robert W. Allen
- 👤 John P. O'Brien
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 17:19
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093
Claims Analysis
Total Claims: 48
Claim 1
Independent Claim
28 words
A cis-complex or -salt of a square planar platinum compound and a nitrogen containing oligomer or polymer selected from the group consisting of polyphosphazenes, polyvinyl pyridine and polyvinylpyrrolidone.
Claim 2
Dependent Claim
28 words
A cis-complex or -salt of a square planar platinum compound and a nitrogen containing oligomer or polymer selected from the group consisting of polyphosphazenes, polyvinyl pyridine and polyvinylpyrrolidone.
Claim 3
Dependent Claim
14 words
The complex or salt of claim 1 wherein said platinum compound is a haloplatinate.
Claim 4
Dependent Claim
14 words
The complex or salt of claim 2 wherein said platinum compound is a chloroplatinate.
Claim 5
Dependent Claim
15 words
The complex or salt of claim 1 wherein said oligomer or polymer is a polyphosphazene.
Claim 6
Dependent Claim
33 words
A cis- complex or -salt of a square planar platinum compound and a polyphosphazene having the structural formula: ##STR7## wherein: n represents the degree of polymerization, and R is alkyl, alkoxy, aryloxy, halogen.
Claim 7
Dependent Claim
33 words
A cis- complex or -salt of a square planar platinum compound and a polyphosphazene having the structural formula: ##STR7## wherein: n represents the degree of polymerization, and R is alkyl, alkoxy, aryloxy, halogen.
Claim 8
Dependent Claim
23 words
A compound according to claim 5 having the structural formula: ##STR8## wherein: n and y represent the degrees of polymerization, and, n/y< 1.0
Claim 9
Dependent Claim
17 words
A compound according to claim 5 having the structural formula: ##STR9## wherein represents a resonance hybride bond.
Claim 10
Dependent Claim
17 words
A compound according to claim 5 having the structural formula: ##STR10## wherein represents a resonance hybrid bond.
Claim 11
Dependent Claim
11 words
A compound according to claim 5 having the structural formula: ##STR11##
Claim 12
Dependent Claim
11 words
A compound according to claim 5 having the structural formula: ##STR12##
Claim 13
Dependent Claim
33 words
A cis-Pt(II) complex prepared by reacting a square planar platinum compound with a nitrogen containing oligomer or polymer selected from the group consisting of polyphosphazenes, polyvinyl pyridine and polyvinylpyrrolidone in an organic solvent.
Claim 14
Dependent Claim
33 words
A cis-Pt(II) complex prepared by reacting a square planar platinum compound with a nitrogen containing oligomer or polymer selected from the group consisting of polyphosphazenes, polyvinyl pyridine and polyvinylpyrrolidone in an organic solvent.
Claim 15
Dependent Claim
14 words
The complex of claim 11 wherein said square planar platinum compound is a chloroplatinate.
Claim 16
Dependent Claim
11 words
The complex of claim 12 wherein said chloroplatinate is potassium chloroplatinate.
Claim 17
Dependent Claim
13 words
The complex of claim 11 wherein said oligomer or polymer is a polyphosphazene.
Claim 18
Dependent Claim
28 words
A cis-Pt(II) complex prepared by reacting [NP(NHCH 3 ) 2 ] n with K 2 PtCl 4 in an organic solvent, wherein n represents the degree of polymerization.
Claim 19
Dependent Claim
28 words
A cis-Pt(II) complex prepared by reacting [NP(NHCH 3 ) 2 ] n with K 2 PtCl 4 in an organic solvent, wherein n represents the degree of polymerization.
Claim 20
Dependent Claim
20 words
A cis-Pt(II) complex prepared by reacting [NP(NHCH 3 ) 2 4 with K 2 PtCl 4 in an organic solvent.
Claim 21
Dependent Claim
20 words
A cis-Pt(II) complex prepared by reacting [NP(NHCH 3 ) 2 4 with K 2 PtCl 4 in an organic solvent.
Claim 22
Dependent Claim
21 words
A cis-Pt(II) complex prepared by reacting [(NP(CH 3 ) 2 ] 4 with K 2 PtCl 4 in an organic solvent.
Claim 23
Dependent Claim
21 words
A cis-Pt(II) complex prepared by reacting [(NP(CH 3 ) 2 ] 4 with K 2 PtCl 4 in an organic solvent.
Claim 24
Dependent Claim
34 words
A cis-Pt(II) salt prepared by reacting a square planar platinum compound with a nitrogen containing oligomer or polymer selected from the group consisting of polyphosphazenes, polyvinyl pyridine and polyvinylpyrrolidone in an acidic aqueous medium.
Claim 25
Dependent Claim
34 words
A cis-Pt(II) salt prepared by reacting a square planar platinum compound with a nitrogen containing oligomer or polymer selected from the group consisting of polyphosphazenes, polyvinyl pyridine and polyvinylpyrrolidone in an acidic aqueous medium.
Claim 26
Dependent Claim
14 words
The salt of claim 18 wherein said square planar platinum compound is a chloroplatinate.
Claim 27
Dependent Claim
14 words
The salt of claim 19 wherein said chloroplatinate is K 2 PtCl 4 .
Claim 28
Dependent Claim
13 words
The salt of claim 18 wherein said oligomer or polymer is a polyphosphazene.
Claim 29
Dependent Claim
29 words
A cis-Pt(II) salt prepared by reacting [NP(NHCH 3 ) 2 ] n with K 2 PtCl 4 in an acidic aqueous medium, wherein n represents the degree of polymerization.
Claim 30
Dependent Claim
29 words
A cis-Pt(II) salt prepared by reacting [NP(NHCH 3 ) 2 ] n with K 2 PtCl 4 in an acidic aqueous medium, wherein n represents the degree of polymerization.
Claim 31
Dependent Claim
22 words
A cis-Pt(II) salt prepared by reacting [NP(NHCH 3 ) 2 ] 4 with K 2 PtCl 4 in an acidic aqueous medium.
Claim 32
Dependent Claim
22 words
A cis-Pt(II) salt prepared by reacting [NP(NHCH 3 ) 2 ] 4 with K 2 PtCl 4 in an acidic aqueous medium.
Claim 33
Dependent Claim
22 words
A cis-Pt(II) salt prepared by reacting [NP(CH 3 ) 2 ] 4 with K 2 PtCl 4 in an acidic aqueous medium.
Claim 34
Dependent Claim
22 words
A cis-Pt(II) salt prepared by reacting [NP(CH 3 ) 2 ] 4 with K 2 PtCl 4 in an acidic aqueous medium.
Claim 35
Independent Claim
37 words
A method comprising reacting a square planar platinum compound with a nitrogen containing polymer or oligomer selected from the group consisting of polyphosphazenes, polyvinyl pyridine and polyvinylpyrrolidone in an organic solvent and recovering the cis-Pt(II) complex formed.
Claim 36
Independent Claim
37 words
A method comprising reacting a square planar platinum compound with a nitrogen containing polymer or oligomer selected from the group consisting of polyphosphazenes, polyvinyl pyridine and polyvinylpyrrolidone in an organic solvent and recovering the cis-Pt(II) complex formed.
Claim 37
Dependent Claim
17 words
The method of claim 25 wherein said square planar platinum compound is K 2 PtCl 4 .
Claim 38
Dependent Claim
13 words
The method of claim 26 wherein said polymer or oligomer is a polyphosphazene.
Claim 39
Dependent Claim
16 words
The method of claim 27 wherein said polyphosphazene is [NP(NHCH 3 ) 2 ] n .
Claim 40
Dependent Claim
16 words
The method of claim 27 wherein said phosphazene is [NP(NHCH 3 ) 2 ] 4 .
Claim 41
Dependent Claim
16 words
The method of claim 27 wherein said phosphazene is [NP(CH 3 ) 2 ] 4 .
Claim 42
Independent Claim
38 words
A method comprising reacting a square planar platinum compound with a nitrogen containing polymer or oligomer selected from the group consisting of polyphosphazenes, polyvinyl pyridine and polyvinylpyrrolidine in an acidic aqueous medium and recovering the cis-Pt(II) salt formed.
Claim 43
Independent Claim
38 words
A method comprising reacting a square planar platinum compound with a nitrogen containing polymer or oligomer selected from the group consisting of polyphosphazenes, polyvinyl pyridine and polyvinylpyrrolidine in an acidic aqueous medium and recovering the cis-Pt(II) salt formed.
Claim 44
Dependent Claim
17 words
The method of claim 31 wherein said square planar platinum compound is K 2 PtCl 4 .
Claim 45
Dependent Claim
13 words
The method of claim 32 wherein said polymer or oligomer is a polyphosphazene.
Claim 46
Dependent Claim
16 words
The method of claim 33 wherein said polyphosphazene is [NP(NHCH 3 ) 2 ] n .
Claim 47
Dependent Claim
16 words
The method of claim 33 wherein said phosphazene is [NP(NHCH 3 ) 2 ] 4 .
Claim 48
Dependent Claim
16 words
The method of claim 33 wherein said phosphazene is [NP(CH 3 ) 2 ] 4 .
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-23 | 1982-10-23 | 1983-04-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-23 | 1986-10-23 | 1987-04-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-23 | 1990-10-23 | 1991-04-24 | $7700.00 | Window Closed / Lapsed |