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US4146637A Expired / Lapsed US ⏱️ 0.0 years remaining

Anti-inflammatory n-acyl substituted benzamides

Assignee: Ludwig Merckle GmbH and Co KG Chem Pharm Fabrik
•
Filing: 1977-05-23
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Granted: 1979-03-27
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Expires: 1997-05-23
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Abstract

Abstract There are disclosed N-acyl substituted benzamides of the general formula: ##STR1## wherein: X is carbon or nitrogen; R 1 is hydrogen, alkyl, halogen, trifluoromethyl, alkoxy, phenoxy or acetoxy; Y is the radical --O--, --NH-- or --S--; Z is an alkylene group containing 1 to 5 carbon atoms, or an alkenylene group containing 1 to 5 carbon atoms, either of which group may be unsubstituted or substituted by an alkyl, alkenyl, phenyl, cycloalkyl, acetyl, amino or halogenphenoxy group; R 2 is hydrogen, an alkyl group containing 1 to 4 carbon atoms, an alkenyl group containing 1 to 4 carbon atoms in which either the alkyl or the alkenyl group may be unsubstituted or substituted with a halogen, phenyl or halogenphenyl substituent; and The value of n, m, and p may each be 0 or 1, and in the case of p=1, pharmaceutically acceptable salts thereof. Also disclosed is a method for making such compounds and pharmaceutical compositions containing such compounds.

Inventors

  • 👤 Gunter Metz
  • 👤 Manfred Specker

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-07 10:40
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/81; C07D213/82

Claims Analysis

Total Claims: 6
Claim 1
Independent Claim 129 words
N-acyl substituted benzamides of the general formula: ##STR39## wherein: R 1 is hydrogen, alkyl, halogen, trifluoromethyl, alkoxy, phenoxy or acetoxy; Z is an alkylene group containing 1 to 5 carbon atoms, or an alkenylene group containing 1 to 5 carbon atoms, either of which group may be unsubstituted or substituted by an alkyl, alkenyl, phenyl, cycloalkyl, acetyl, amino or halogenphenoxy group; R 2 is hydrogen, an alkyl group containing 1 to 4 carbon atoms, an alkenyl group containing 1 to 4 carbon atoms in which either the alkyl or the alkenyl group may be unsubstituted or substituted with a halogen, phenyl or halogenphenyl substituent; and the value of m and p may each be 0 or 1, and in the case of p = 1, pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim 129 words
N-acyl substituted benzamides of the general formula: ##STR39## wherein: R 1 is hydrogen, alkyl, halogen, trifluoromethyl, alkoxy, phenoxy or acetoxy; Z is an alkylene group containing 1 to 5 carbon atoms, or an alkenylene group containing 1 to 5 carbon atoms, either of which group may be unsubstituted or substituted by an alkyl, alkenyl, phenyl, cycloalkyl, acetyl, amino or halogenphenoxy group; R 2 is hydrogen, an alkyl group containing 1 to 4 carbon atoms, an alkenyl group containing 1 to 4 carbon atoms in which either the alkyl or the alkenyl group may be unsubstituted or substituted with a halogen, phenyl or halogenphenyl substituent; and the value of m and p may each be 0 or 1, and in the case of p = 1, pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim 35 words
A compound as defined in claim 1 wherein R 1 is 4-Cl, Z is the group --C(CH 3 ) 2 --, R 2 is hydrogen and the values of m and p are each 1.
Claim 4
Dependent Claim 33 words
A compound as defined in claim 1 wherein R 1 is 4-Cl, Z is the radical --CH 2 --, R 2 is hydrogen and the values of m and p are each 1.
Claim 5
Dependent Claim 31 words
A compound as defined in claim 1 wherein R 1 is 4-Cl, Z is the group ##STR40## R 2 is hydrogen and the values of m and p are each 1.
Claim 6
Dependent Claim 29 words
A pharmaceutical composition having anti-inflammatory and anti-allergic activity comprising an effective anti-inflammatory and anti-allergic amount of a compound as defined in claim 1 and a pharmaceutically acceptable carrier therefor.

References Cited (Backward Citations)

US3818021A Cited
US3898278A Cited
US4002655A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1982-03-26 1982-09-25 1983-03-27 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1986-03-26 1986-09-25 1987-03-27 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1990-03-26 1990-09-25 1991-03-27 $7700.00 Window Closed / Lapsed

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