US4002655A
Expired / Lapsed
US
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Glycyrrhetinic acid derivatives
Assignee: Biorex Laboratories Ltd
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Filing: 1975-02-10
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Granted: 1977-01-11
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Expires: 1995-02-10
Abstract
Abstract The present invention provides new and pharmaceutically useful amides of the general formula: ##STR1## wherein X is the acyl residue of 18α- or 18β-glycyrrhetinic acid, the 3-hydroxyl group of which can be acylated with a mono-, di- or polybasic inorganic or organic acid, or X is the acyl residue of 3-keto-18α- or -18β-glycyrrhetinic acid; and the metoclopramide salts of those compounds containing at least one free carboxylic acid group.
Inventors
- 👤 David William Hawkins
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 02:53
CPC Classifications
C; C07; C07J; C07J63/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
62 words
A compound selected from the group consisting of compounds of the formula ##STR4## wherein X is the acyl residue of 18α- or 18β-glycyrrhetinic acid, the 3-hydroxyl group of which is optionally acylated with a monobasic fatty acid containing up to 20 carbon atoms or succinic acid and the metoclopramide salt of said compound wherein the 3-hydroxy group is acylated with succinic acid.
Claim 2
Dependent Claim
62 words
A compound selected from the group consisting of compounds of the formula ##STR4## wherein X is the acyl residue of 18α- or 18β-glycyrrhetinic acid, the 3-hydroxyl group of which is optionally acylated with a monobasic fatty acid containing up to 20 carbon atoms or succinic acid and the metoclopramide salt of said compound wherein the 3-hydroxy group is acylated with succinic acid.
Claim 3
Dependent Claim
39 words
A compound according to claim 1, wherein X is the acyl residue of 18α- or 18β-glycyrrhetinic acid, the 3-hydroxyl group of which is optionally acylated with a monobasic fatty acid containing up to 20 carbon atoms or succinic acid.
Claim 4
Dependent Claim
9 words
The compound according to claim 1, which is N-(3β-O-acetyl-18β-glycyrrhetyl)-4-amino-5-chloro-N'-(2-diethylaminoethyl)-2-methoxy-benzamide.
Claim 5
Dependent Claim
9 words
The compound according to claim 1, which is N-(18β-glycyrrhetyl)-4-amino-5-chloro-N'-(2-diethylaminoethyl)-2-methoxy-benzamide.
Claim 6
Dependent Claim
9 words
The compound according to claim 1, which is N-(3β-O-lauroyl-18β-glycyrrhetyl)-4-amino-5-chloro-N'-(2-diethylaminoethyl)-2-methoxy-benzamide.
Claim 7
Dependent Claim
9 words
The compound according to claim 1, which is N-[3β-O-(γ-carboxypropionyl)-18β-glycyrrhetyl]-4-amino-5-chloro-N'-(2-diethylaminoethyl)-2-methoxy-benzamide.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-01-11 | 1980-07-12 | 1981-01-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-01-11 | 1984-07-12 | 1985-01-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-01-11 | 1988-07-12 | 1989-01-11 | $7700.00 | Window Closed / Lapsed |