US4146612A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Somatostatin analogs
Assignee: Merck and Co Inc
•
Filing: 1978-06-29
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Granted: 1979-03-27
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Expires: 1998-06-29
Abstract
Abstract Somatostatin analogs having the structural formula: <CHEM> wherein A is Phe, Tyr, O-Me-Tyr, B is Phe, Tyr, C is Thr, Val, wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid addition salts thereof are prepared by the solid phase method. These peptides have the property of inhibiting release of insulin, inhibiting growth hormone release and inhibiting glucagon release in humans and animals without materially affecting gastric secretion.
Inventors
- 👤 Daniel F. Veber
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 18:21
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/655; C07K14/6555; A; A61; A61P; A61P3/00; A61P3/02; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/16
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
46 words
Compounds of the formula: ##STR22## wherein A is Phe, Tyr, O-Me-Tyr, B is Phe, Tyr, C is Thr, Val, R is H, COOH, wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid addition salts and carboxylic acid salts thereof.
Claim 2
Dependent Claim
46 words
Compounds of the formula: ##STR22## wherein A is Phe, Tyr, O-Me-Tyr, B is Phe, Tyr, C is Thr, Val, R is H, COOH, wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid addition salts and carboxylic acid salts thereof.
Claim 3
Dependent Claim
15 words
The compound according to claim 1 having the formula: ##STR23## wherein R is H, COOH.
Claim 4
Dependent Claim
59 words
A composition comprising a therapeutically effective amount of the peptides having the structure: ##STR24## wherein A is Phe, Tyr, O-Me-Tyr, B is Phe-Tyr, C is Thr, Val, R is H, COOH, wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid addition salts and carboxylic acid salts thereof in a pharmaceutically acceptable excipient.
Claim 5
Dependent Claim
59 words
A composition comprising a therapeutically effective amount of the peptides having the structure: ##STR24## wherein A is Phe, Tyr, O-Me-Tyr, B is Phe-Tyr, C is Thr, Val, R is H, COOH, wherein the ring formed by the peptide backbone contains 26 atoms and pharmaceutically acceptable non-toxic acid addition salts and carboxylic acid salts thereof in a pharmaceutically acceptable excipient.
References Cited (Backward Citations)
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Cited
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-03-26 | 1982-09-25 | 1983-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-03-26 | 1986-09-25 | 1987-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-03-26 | 1990-09-25 | 1991-03-27 | $7700.00 | Window Closed / Lapsed |