US3904594A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Somatostatin and acylated des-(ala' 1', gly' 2') derivatives thereof
Assignee: Salk Institute for Biological Studies
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Filing: 1974-06-12
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Granted: 1975-09-09
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Expires: 1994-06-12
Abstract
Abstract Various peptides have been prepared which inhibit the secretion of growth hormone in mammalians, including humans. The peptides are useful in the treatment of acromegaly and diabetes and are also useful in controlling the release of thyroid stimulating hormone.
Inventors
- 👤 Roger C L Guillemin
- 👤 Jr Paul E Brazeau
- 👤 Roger C Burgus
- 👤 Nicholas C Ling
- 👤 Jean E F Rivier
- 👤 Jr Wylie W Vale
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 04:54
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/655; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/16
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
61 words
A COMPOUND WHICH IS CAPABLE OF INHIBITING THE SECRETION OF GROWTH HORMONE IN MAMMALIANS, SAID COMPOUND BEING A PEPTIDE SELECTED FROM THE GROUP CONSISTING OF R-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS OH AND R-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THRSER-CYS-OH WHERE R IS AN ACYLATING AGENT SELECTED FROM THE GROUP CONSISTING OF AMINO ACIDS DIPEPTIDES TRIPEPTIDES AND ALIPHATIC AROMATIC AND CYCLIC ORGANIC ACIDS HAVING FROM 1 TO 10 CARBON ATOMS OR HYDROGEN.
Claim 2
Dependent Claim
61 words
A COMPOUND WHICH IS CAPABLE OF INHIBITING THE SECRETION OF GROWTH HORMONE IN MAMMALIANS, SAID COMPOUND BEING A PEPTIDE SELECTED FROM THE GROUP CONSISTING OF R-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS OH AND R-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THRSER-CYS-OH WHERE R IS AN ACYLATING AGENT SELECTED FROM THE GROUP CONSISTING OF AMINO ACIDS DIPEPTIDES TRIPEPTIDES AND ALIPHATIC AROMATIC AND CYCLIC ORGANIC ACIDS HAVING FROM 1 TO 10 CARBON ATOMS OR HYDROGEN.
Claim 3
Dependent Claim
13 words
A compound in accordance with claim 1 wherein R is an amino acid.
Claim 4
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R is a dipeptide.
Claim 5
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R is a tripeptide.
Claim 6
Dependent Claim
21 words
A compound in accordance with claim 1 wherein R is an aliphatic organic acid having from 1 to 10 carbon atoms.
Claim 7
Dependent Claim
20 words
A compound in accordance with claim 1 wherein R is an aromatic acid having from 1 to 10 carbon atoms.
Claim 8
Dependent Claim
21 words
A compound in accordance with claim 1 wherein R is a cyclic organic acid having from 1 to 10 carbon atoms.
Claim 9
Dependent Claim
29 words
A compound in accordance with claim 1 wherein R is selected from the group consisting of Gly, Ala, Ala-Gly, Acetyl-Ala-Gly, Tyr-Gly, Sarc-Gly, Tyr-Ala-Gly, Ala-Tyr-Gly, Acetyl, Acryl, Pivalyl, and Benzoyl.
Claim 10
Dependent Claim
11 words
A compound in accordance with claim 8 wherein R is Gly.
Claim 11
Dependent Claim
11 words
A compound in accordance with claim 8 wherein R is Ala.
Claim 12
Dependent Claim
11 words
A compound in accordance with claim 8 wherein R is Ala-Gly.
Claim 13
Dependent Claim
11 words
A compound in accordance with claim 8 wherein R is Acetyl-Ala-Gly.
Claim 14
Dependent Claim
11 words
A compound in accordance with claim 8 wherein R is Tyr-Gly.
Claim 15
Dependent Claim
11 words
A compound in accordance with claim 8 wherein R is Sarc-Gly.
Claim 16
Dependent Claim
11 words
A compound in accordance with claim 8 wherein R is Tyr-Ala-Gly.
Claim 17
Dependent Claim
11 words
A compound in accordance with claim 8 wherein R is Ala-Tyr-Gly.
Claim 18
Dependent Claim
11 words
A compound in accordance with claim 8 wherein R is Acetyl.
Claim 19
Dependent Claim
11 words
A compound in accordance with claim 8 wherein R is Acryl.
Claim 20
Dependent Claim
11 words
A compound in accordance with claim 8 wherein R is Pivalyl.
Claim 21
Dependent Claim
11 words
A compound in accordance with claim 8 wherein R is Benzoyl.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-08 | 1979-03-10 | 1979-09-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-08 | 1983-03-10 | 1983-09-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-08 | 1987-03-10 | 1987-09-09 | $7700.00 | Window Closed / Lapsed |