US3882098A
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Synthesis of des-Ala{hu 1{b , Gly{hu 2{b , Asn{hu 5{b -SRIF and intermediates
Assignee: Wyeth LLC
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Filing: 1974-01-03
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Granted: 1975-05-06
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Expires: 1994-01-03
Abstract
Abstract The undecapeptide H-Cys-Lys-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-CysOH, its oxidized form and intermediates obtained in such synthesis are described. The oxidized form of this undecapeptide inhibits the secretion of the hormone somatotropin.
Inventors
- 👤 Dimitrios Sarantakis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 23:22
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/655; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/16
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
33 words
An undecapeptide selected from those of the formula: H-Cys-Lys-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH, H-Cys-Lys-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH and the non-toxic acid addition salts thereof, said amino acid residues in said undecapeptide having an asymmetric Alpha -carbon being of the L-configuration.
Claim 2
Dependent Claim
33 words
An undecapeptide selected from those of the formula: H-Cys-Lys-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH, H-Cys-Lys-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH and the non-toxic acid addition salts thereof, said amino acid residues in said undecapeptide having an asymmetric Alpha -carbon being of the L-configuration.
Claim 3
Dependent Claim
17 words
A compound according to claim 1 which is: L-cysteinyl-L-lysyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L -threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine and a non-toxic acid addition salt thereof.
Claim 4
Dependent Claim
5 words
AN UNDECAPEPTIDE OF THE FORMULA:
Claim 5
Dependent Claim
5 words
AN UNDECAPEPTIDE OF THE FORMULA:
Claim 6
Dependent Claim
10 words
A compound according to claim 3 wherein R is tert-butyloxycarbonyl.
Claim 7
Dependent Claim
22 words
A compound according to claim 4 wherein R1 is p-methoxybenzyl, R2 is benzyloxycarbonyl, R3 and R4 are benzyl and R5 is benzyl.
Claim 8
Dependent Claim
21 words
A compound according to claim 1 which is: L-cystinyl-L-lysyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L -treonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cystine (cyclic 1, 11 disulfide) and a non-toxic acid addition salt thereof.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-05-05 | 1978-11-04 | 1979-05-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-05-05 | 1982-11-04 | 1983-05-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-05-05 | 1986-11-04 | 1987-05-06 | $7700.00 | Window Closed / Lapsed |