Patent US4143041A successfully refreshed from Google Patents.
US4143041A
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4'-Deoxyvincristine and related compounds
Assignee: Eli Lilly and Co
•
Filing: 1977-11-25
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Granted: 1979-03-06
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Expires: 1997-11-25
Abstract
Abstract 4'-Deoxyvincristine, 4'-deoxy-1-formylleurosidine and the corresponding 4-desacetyl derivatives, useful in inhibiting the growth of experimental tumors.
Inventors
- 👤 Gerald L. Thompson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 05:58
CPC Classifications
C; C07; C07D; C07D519/00; C07D519/04
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
36 words
A compound of the formula ##STR3## wherein R 1 is OH or acetoxy and one of R 3 and R 4 is hydrogen and the other is ethyl, and pharmaceutically-acceptable salts thereof formed with non-toxic acids.
Claim 2
Dependent Claim
36 words
A compound of the formula ##STR3## wherein R 1 is OH or acetoxy and one of R 3 and R 4 is hydrogen and the other is ethyl, and pharmaceutically-acceptable salts thereof formed with non-toxic acids.
Claim 3
Dependent Claim
12 words
A compound according to claim 1 in which R 1 is acetoxy.
Claim 4
Dependent Claim
10 words
A sulfate salt of a compound according to claim 2.
Claim 5
Dependent Claim
25 words
A compound according to claim 1 in which R 1 is acetoxy, R 3 is hydrogen and R 4 is ethyl, said compound being 4'-deoxyvincristine.
Claim 6
Dependent Claim
15 words
A sulfate salt of a compound according to claim 4, said salt being 4'-deoxyvincristine sulfate.
Claim 7
Dependent Claim
25 words
A compound according to claim 1 in which R 1 is acetoxy, R 3 is ethyl and R 4 is hydrogen, said compound being 4'-deoxy-1-formylleurosidine.
Claim 8
Dependent Claim
15 words
A sulfate salt of a compound according to claim 6, said salt being 4'-deoxy-1-formylleurosidine sulfate.
Claim 9
Dependent Claim
25 words
A compound according to claim 1 in which R 1 is hydroxyl, R 4 is hydrogen and R 3 is ethyl, said compound being 4'-deoxy-4-desacetyl-1-formylleurosidine.
Claim 10
Dependent Claim
21 words
A compound of the formula ##STR4## wherein one of R 3 and R 4 is hydrogen and the other is ethyl.
Claim 11
Dependent Claim
21 words
A compound of the formula ##STR4## wherein one of R 3 and R 4 is hydrogen and the other is ethyl.
Claim 12
Dependent Claim
20 words
A compound according to claim 9 wherein R 3 is ethyl and R 4 is H, said compound being 4-desacetyl-4'-deoxyleurosidine.
References Cited (Backward Citations)
US3392173A
Cited
US4029663A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-03-05 | 1982-09-04 | 1983-03-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-03-05 | 1986-09-04 | 1987-03-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-03-05 | 1990-09-04 | 1991-03-06 | $7700.00 | Window Closed / Lapsed |