US4029663A
Expired / Lapsed
US
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Dimeric anhydro-vinca derivatives
Assignee: Eli Lilly and Co
•
Filing: 1975-07-10
•
Granted: 1977-06-14
•
Expires: 1995-07-10
Abstract
Abstract Dimeric Vinca alkaloids are converted to three separable anhydro derivatives, useful as mitotic inhibitors or as intermediates for the preparation of other oncogenetically active alkaloids.
Inventors
- 👤 Gerald E. Gutowski
- 👤 Jean C. Miller
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 16:29
CPC Classifications
C; C07; C07D; C07D519/00; C07D519/04; A; A61; A61P; A61P35/00; A61P43/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
50 words
The compound represented by the formula ##STR6## wherein R is OCH 3 , NH 2 , NHCH 3 , NHC 2 H 5 , NH-C 2 H 4 OH or NH-NH 2 ; R" is CH 3 , H, or formyl; R' is hydroxy or acetoxy and Z is ##STR7##
Claim 2
Dependent Claim
50 words
The compound represented by the formula ##STR6## wherein R is OCH 3 , NH 2 , NHCH 3 , NHC 2 H 5 , NH-C 2 H 4 OH or NH-NH 2 ; R" is CH 3 , H, or formyl; R' is hydroxy or acetoxy and Z is ##STR7##
Claim 3
Dependent Claim
13 words
The compound according to claim 1, said compound being 3',4'-anhydro C-4 desacetyl vincristine.
Claim 4
Dependent Claim
15 words
The compound according to claim 1, said compound being 4',20'-anhydro C-4 desacetyl vincristine (isomer 1)
Claim 5
Dependent Claim
15 words
The compound according to claim 1, said compound being 4',20'-anhydro C-4 desacetyl vincristine (isomer 2).
Claim 6
Dependent Claim
13 words
The compound according to claim 1, said compound being 3',4'-anhydro C-4 desacetyl VLB.
Claim 7
Dependent Claim
15 words
The compound according to claim 1, said compound being 4',20'-anhydro C-4 desacetyl VLB (isomer 1).
Claim 8
Dependent Claim
15 words
The compound according to claim 1, said compound being 4',20'-anhydro C-4 desacetyl VLB (isomer 2).
Claim 9
Dependent Claim
116 words
The process which comprises the step of contacting a compound of the formula ##STR8## wherein R is OCH 3 , NH 2 , NH-NH 2 , NHC 2 H 5 , NH-C 2 H 4 OH or NHCH 3 , NHC 2 H 5 , NH-C 2 H 4 OH R' is OH or ##STR9## R" is CH 3 H or CHO, and one of R'" and R"" is ethyl, the other being hydroxy, with cold concentrated sulfuric acid to form a compound of the formula ##STR10## wherein R is OCH 3 , NH 2 , NHCH 3 , or NH-NH 2 ; R" is CH 3 or CHO; R' is hydroxy and Z is ##STR11##
Claim 10
Dependent Claim
116 words
The process which comprises the step of contacting a compound of the formula ##STR8## wherein R is OCH 3 , NH 2 , NH-NH 2 , NHC 2 H 5 , NH-C 2 H 4 OH or NHCH 3 , NHC 2 H 5 , NH-C 2 H 4 OH R' is OH or ##STR9## R" is CH 3 H or CHO, and one of R'" and R"" is ethyl, the other being hydroxy, with cold concentrated sulfuric acid to form a compound of the formula ##STR10## wherein R is OCH 3 , NH 2 , NHCH 3 , or NH-NH 2 ; R" is CH 3 or CHO; R' is hydroxy and Z is ##STR11##
References Cited (Backward Citations)
US3097137A
Cited
US3352868A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-06-13 | 1980-12-13 | 1981-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-06-13 | 1984-12-13 | 1985-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-06-13 | 1988-12-13 | 1989-06-14 | $7700.00 | Window Closed / Lapsed |