1-Aryloxy-3-thenamidoalkylamino-2-propanol derivatives

Claim 1

An alkanolamine derivative selected from a compound of the formula: ##STR15## wherein A is alkylene of from 2 to 12 carbon atoms; wherein X is carbonyl (--CO--) or sulphonyl (--SO 2 --); wherein Y is a direct link, or is alkylene, oxyalkylene or alkyleneoxy each of up to 6 carbon atoms, or imino (--NH--), or alkylimino, iminoalkylene, iminoalkyleneoxy or iminoalkylenecarbonyloxy each of up to 6 carbon atoms, or oxygen; wherein R 1 is thienyl; wherein R 2 and R 3 , which may be the same or different, each is hydrogen, halogen, hydroxy, amino, nitro or cyano, or alkyl, hydroxymethyl, 1-hydroxyethyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkylthio, cycloalkoxy, alkenyloxy, alkynyloxy or alkanoyl each of up to 6 carbon atoms or aryl, aryloxy or dialkylamino each of up to 12 carbon atoms; or wherein R 2 and R 3 together form trimethylene, tetramethylene, 1-oxotetramethylene, propenylene, but-2-enylene or buta-1,3-dienylene such that together with the adjacent benzene ring they form, respectively, indanyl, 5,6,7,8-tetrahydronaphthyl, 5-oxo-5,6,7,8,-tetrahydronaphthyl, indenyl, 5,8-dihydronaphthyl or naphthyl; and wherein R 4 is hydrogen or amidic or the formula: R.sup.15 R.sup.16 N--CO--Q-- r.sup.15 r.sup.16 n--co--nh--q-- r.sup.15 r.sup.16 n--co--q.sup.1 --o-- r.sup.16 --x--nr.sup.15 --q-- or wherein Q is a direct link or is alkylene or alkenylene each of up to 6 carbon atoms; wherein Q 1 is alkylene of up to 6 carbon atoms; wherein R 15 is hydrogen or alkyl of up to 6 carbon atoms; wherein R 16 is hydrogen or alkenyl, cycloalkyl, hydroxyalkyl or alkoxyalkyl each of up to 6 carbon atoms, or alkyl, aryl, aralkyl or aralkenyl each of up to 10 carbon atoms; and wherein X is as defined above; and a non-toxic, pharmaceutically-acceptable acid-addition salt thereof.