US3944611A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Nitrogen-containing compounds
Assignee: Imperial Chemical Industries Ltd
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Filing: 1974-06-13
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Granted: 1976-03-16
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Expires: 1994-06-13
Abstract
Abstract Novel 1-aryl-2-amidoalkylaminoethanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart diseases. The compounds possess beta -adrenergic blocking activity. Representative of the compounds disclosed is 1-phenyl-2-(1,1-dimethyl-2-phenylacetamidoethyl)amino-ethanol.
Inventors
- 👤 Leslie Harold Smith
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 23:42
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/18; A61P; A61P25/00; A61P25/02; C; C07; C07C; C07C233/00; C07C271/00; C07C271/06; C07C271/08; C07C271/10; C07C271/20; C07C275/00; C07C275/04; C07C275/20; C07C275/24; C07C275/28
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
149 words
An ethanolamine derivative selected from the group consisting of compounds of the formula: ##SPC28## wherein A is alkylene of from 2 to 6 carbon atoms, wherein R 1 is hydrogen or alkyl, alkenyl, halogenoalkyl or cycloalkyl each of up to 6 carbon atoms, or aryl of the formula: ##SPC29## wherein R 2 , R 3 , R 12 , and R 13 , which may be the same or different, each is hydrogen, halogen, nitro, amino or cyano, or alkyl alkenyl, alkoxy, alkenyloxy, hydroxalkyl, alkanoyl, acylamino each of up to 6 carbon atoms, wherein R 4 is hydrogen, hydroxy or carbamoyl, wherein R 5 is hydrogen or alkyl of up to 6 carbon atoms, wherein X is carbonyl and wherein Y is a direct link, or alkylene or alkyleneoxy each of up to 6 carbon atoms, or (except when R 1 is hydrogen) oxygen, and the acid-addition salts thereof.
Claim 2
Dependent Claim
149 words
An ethanolamine derivative selected from the group consisting of compounds of the formula: ##SPC28## wherein A is alkylene of from 2 to 6 carbon atoms, wherein R 1 is hydrogen or alkyl, alkenyl, halogenoalkyl or cycloalkyl each of up to 6 carbon atoms, or aryl of the formula: ##SPC29## wherein R 2 , R 3 , R 12 , and R 13 , which may be the same or different, each is hydrogen, halogen, nitro, amino or cyano, or alkyl alkenyl, alkoxy, alkenyloxy, hydroxalkyl, alkanoyl, acylamino each of up to 6 carbon atoms, wherein R 4 is hydrogen, hydroxy or carbamoyl, wherein R 5 is hydrogen or alkyl of up to 6 carbon atoms, wherein X is carbonyl and wherein Y is a direct link, or alkylene or alkyleneoxy each of up to 6 carbon atoms, or (except when R 1 is hydrogen) oxygen, and the acid-addition salts thereof.
Claim 3
Dependent Claim
68 words
An ethanolamine derivative as claimed in claim 1 selected from the group consisting of compounds of the formula given in claim 1 wherein A is ethylene, 1-methylethylene or 1,1-dimethylethylene, wherein R 1 is alkyl or cycloalkyl each of up to 6 carbon atoms, wherein R 2 and R 3 are both hydrogen, wherein X is carbonyl and wherein Y is a direct link, and the acid-addition salts thereof.
Claim 4
Dependent Claim
60 words
An ethanolamine derivative as claimed in claim 1 selected from the group consisting of compounds of the formula given in claim 1 wherein A is ethylene, 1-methylethylene or 1,1-dimethylethylene, wherein R 1 is phenyl, chlorophenyl or methoxyphenyl, wherein R 2 and R 3 are both hydrogen, wherein X is carbonyl and wherein Y is methylene, and the acid-addition salts thereof.
Claim 5
Dependent Claim
26 words
An ethanolamine derivative as claimed in claim 1 selected from 1-phenyl-2-(β-cyclopentanecarbonamidoethyl)amino-ethanol; 1-phenyl-2-(β-isobutyramidoethyl)aminoethanol; 1-phenyl-2-(β-p-methoxyphenylacetamidoethyl)aminoethanol; 1-phenyl-2-(β-propionamidoethyl)aminoethanol; 1-phenyl-2-(62 -n-butyramidoethyl)aminoethanol; 1-phenyl-2-(β-phenylacetamidoethyl)aminoethanol; 1-phenyl-2-(1-methyl-2-p-chlorophenyl-acetamidoethyl)aminoethanol; 1-phenyl-2-(1,1-dimethyl-2-iso-butyramidoethyl)aminoethanol and 1-phenyl-2-(1,1-dimethyl-2-phenylacetamidoethyl)aminoethanol and the acid-addition salts thereof.
Claim 6
Dependent Claim
8 words
The compound 1-phenyl-2-(1-methyl-2-phenylacetamido-ethyl)aminoethanol or an acid-addition salt thereof.
Claim 7
Dependent Claim
8 words
The compound 1-phenyl-2-(1-methyl-2-phenylacetamido-ethyl)aminoethanol or an acid-addition salt thereof.
Claim 8
Dependent Claim
10 words
The compound (1R)-1-phenyl-2-[(1R)-1-methyl-2-phenylacetamidoethyl]aminoethanol or (1R)-1-phenyl-2-[(1S)-1-methyl-2-phenylacetamidoethyl]aminoethanol or an acid-addition salt thereof.
Claim 9
Dependent Claim
10 words
The compound (1R)-1-phenyl-2-[(1R)-1-methyl-2-phenylacetamidoethyl]aminoethanol or (1R)-1-phenyl-2-[(1S)-1-methyl-2-phenylacetamidoethyl]aminoethanol or an acid-addition salt thereof.
Claim 10
Dependent Claim
35 words
An acid-addition salt as claimed in claim 1 which is a hydrochloride, hydrobromide, phosphate, sulphate, oxalate, lactate, tartrate, acetate, salicylate, citrate, benzoate, β-naphthoate, adipate or 1,1-methylene-bis-(2-hydroxy-3-naphthoate), or a salt derived from a sulphonated polystyrene resin.
References Cited (Backward Citations)
US3676493A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-03-16 | 1979-09-15 | 1980-03-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-03-16 | 1983-09-15 | 1984-03-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-03-16 | 1987-09-15 | 1988-03-16 | $7700.00 | Window Closed / Lapsed |