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US4141968A
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Novel salts of 1,3-bis-(β-ethylhexyl)-5-amino-5-methyl-hexahydropyrimidine in compositions having bacteriostatic activity
Assignee: Dolorgiet Beteiligungs GmbH
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Filing: 1976-11-03
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Granted: 1979-02-27
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Expires: 1996-11-03
Abstract
Abstract Novel salts of 1,3-bis-(β-ethylhexyl)-5-amino-5-methyl-hexahydropyrimidine (hexetidine) with substituted benzoic acids and processes of preparing these salts are described. These novel salts have useful bacteriostatic activity and show stability in storage. The invention accordingly comprises compositions containing the novel salts and having bacteriostatic activity.
Inventors
- 👤 Wilhelm Kunz
- 👤 Klaus Posselt
- 👤 Manfred Lohner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 12:33
CPC Classifications
C; C07; C07C; C07C63/00; C07C63/14; C07C63/15; C07C63/26; C07C63/28; C07D; C07D239/00; C07D239/02; C07D239/04
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
91 words
The method of treating the mouth cavity for inhibiting the growth of microorganisms therein which comprises applying thereto an effective amount of a composition containing at least one salt of 1,3-bis-(β-ethylhexyl)-5-amino-5-methyl-hexahydropyrimidine of the general formula ##STR4## with an aromatic carboxylic acid of the general formula ##STR5## wherein X is a member selected from the group consisting of --COOH, --OH, --NH 2 , --SO 3 H and --SO 2 NH 2 , as active ingredient together with at least one member selected from the group consisting of conventional diluents and carrier materials.
Claim 2
Independent Claim
91 words
The method of treating the mouth cavity for inhibiting the growth of microorganisms therein which comprises applying thereto an effective amount of a composition containing at least one salt of 1,3-bis-(β-ethylhexyl)-5-amino-5-methyl-hexahydropyrimidine of the general formula ##STR4## with an aromatic carboxylic acid of the general formula ##STR5## wherein X is a member selected from the group consisting of --COOH, --OH, --NH 2 , --SO 3 H and --SO 2 NH 2 , as active ingredient together with at least one member selected from the group consisting of conventional diluents and carrier materials.
Claim 3
Dependent Claim
22 words
Method of treating the mouth cavity according to claim 1 characterized, that compositions are used which contain 1,3-bis-(β-ethylhexyl)-5-amino-5-methylhexahydropyrimidine-terephthalate of the formula ##STR6##
Claim 4
Dependent Claim
18 words
Method of treating the mouth cavity according to claim 1 characterized, that compositions are used which contain 1,3-bis-(β-ethylhexyl)-5-amino-5-methylhexahydropyrimidine-4-sulfamoyl-benzoate.
Claim 5
Dependent Claim
18 words
Method of treating the mouth cavity according to claim 1 characterized, that compositions are used which contain 1,3-bis-(β-ethylhexyl)-5-amino-5-methylhexahydropyrimidine-4-hydroxybenzoate.
Claim 6
Dependent Claim
18 words
Method of treating the mouth cavity according to claim 1 characterized, that compositions are used which contain 1,3-bis-(β-ethylhexyl)-5-amino-5-methyl-hexahydropyrimidine-4-amino-benzoate.
Claim 7
Dependent Claim
18 words
Method of treating the mouth cavity according to claim 1 characterized, that compositions are used which contain 1,3-bis-(β-ethylhexyl)-5-amino-5-methyl-hexahydropyrimidine-4-sulfo-benzoate.
Claim 8
Dependent Claim
85 words
Compositions having bacteriostatic activity, suitable for inhibiting growth of microorganisms in the region of the mouth cavity, said compositions containing at least one salt of 1,3-bis-(β-ethylhexyl)-5-amino-5-methyl-hexahydro-pyrimidine of the general formula ##STR7## with an aromatic carboxylic acid of the formula ##STR8## wherein X is a member selected from the group consisting of --COOH, --OH, --NH 2 , --SO 3 H and --SO 2 NH 2 , as active ingredient together with at least one member selected from the group consisting of conventional diluents and carrier materials.
Claim 9
Dependent Claim
85 words
Compositions having bacteriostatic activity, suitable for inhibiting growth of microorganisms in the region of the mouth cavity, said compositions containing at least one salt of 1,3-bis-(β-ethylhexyl)-5-amino-5-methyl-hexahydro-pyrimidine of the general formula ##STR7## with an aromatic carboxylic acid of the formula ##STR8## wherein X is a member selected from the group consisting of --COOH, --OH, --NH 2 , --SO 3 H and --SO 2 NH 2 , as active ingredient together with at least one member selected from the group consisting of conventional diluents and carrier materials.
Claim 10
Dependent Claim
8 words
Composition of claim 7, wherein X is --COOH.
Claim 11
Dependent Claim
12 words
Composition of claim 7, wherein X is --SO 2 NH 2 .
Claim 12
Dependent Claim
8 words
Composition of claim 7, wherein X is --OH.
Claim 13
Dependent Claim
10 words
Composition of claim 7, wherein X is --NH 2 .
Claim 14
Dependent Claim
10 words
Composition of claim 7, wherein X is --SO 3 H.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-26 | 1982-08-28 | 1983-02-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-26 | 1986-08-28 | 1987-02-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-26 | 1990-08-28 | 1991-02-27 | $7700.00 | Window Closed / Lapsed |