Patent US4130556A successfully refreshed from Google Patents.
US4130556A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Chemical products and methods
Assignee: Ortho Pharmaceutical Corp
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Filing: 1977-10-03
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Granted: 1978-12-19
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Expires: 1997-10-03
Abstract
Abstract Novel compounds obtained from the zoapatle plant and methods of obtaining these compounds from the plant material are described. The novel compounds possess useful activity as central nervous system depressants as well as utero-evacuants.
Inventors
- 👤 Michael P. Wachter
- 👤 Ramesh M. Kanojia
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 16:51
CPC Classifications
A; A61; A61K; A61K36/00; A61K36/18; A61K36/185; A61K36/28; A61K31/00; A61K31/33; A61K31/335; C; C07; C07D; C07D313/00; C07D313/02; C07D313/04
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
130 words
The method of purifying crude extracts containing biologically active materials obtained from the zoapatle plant selected from the species consisting of Montanoa tomentosa and Montanoa floribunda which comprises the steps of: dissolving the crude extract in a water-immiscible organic solvent, washing the resulting solution with an aqueous solution of a mild base and separating the organic phase from the aqueous phase, chromatographing the solution through a column of adsorbent material, eluting the column with a mixture of a polar and a non-polar solvent, combining the fractions containing biologically active materials and removing the solvent therefrom, dissolving the residue in a water-immiscible organic solvent, chromatographing the solution through a column of an organic polymeric gel, eluting the column with a non-polar organic solvent and collecting the fractions containing biologically active materials.
Claim 2
Independent Claim
130 words
The method of purifying crude extracts containing biologically active materials obtained from the zoapatle plant selected from the species consisting of Montanoa tomentosa and Montanoa floribunda which comprises the steps of: dissolving the crude extract in a water-immiscible organic solvent, washing the resulting solution with an aqueous solution of a mild base and separating the organic phase from the aqueous phase, chromatographing the solution through a column of adsorbent material, eluting the column with a mixture of a polar and a non-polar solvent, combining the fractions containing biologically active materials and removing the solvent therefrom, dissolving the residue in a water-immiscible organic solvent, chromatographing the solution through a column of an organic polymeric gel, eluting the column with a non-polar organic solvent and collecting the fractions containing biologically active materials.
Claim 3
Dependent Claim
14 words
The method of claim 1 wherein the species of zoapatle plant is Montanoa tomentosa.
Claim 4
Dependent Claim
23 words
The method of claim 1 wherein the water-immiscible organic solvent is selected from an aromatic hydrocarbon, a chlorinated hydrocarbon or an aliphatic ether.
Claim 5
Dependent Claim
16 words
The method of claim 1 wherein the organic solvent is selected from ether, chloroform or benzene.
Claim 6
Dependent Claim
18 words
The method of claim 1 wherein the adsorbent material is selected from silicic acid, silica gel and florisil.
Claim 7
Dependent Claim
17 words
The method of claim 1 wherein the mixture of polar and non-polar solvents comprises chloroform and isopropanol.
Claim 8
Dependent Claim
14 words
The method of claim 1 wherein the polymeric gel is a vinyl acetate copolymer.
Claim 9
Dependent Claim
11 words
The method of claim 1 wherein the non-polar solvent is benzene.
Claim 10
Dependent Claim
12 words
The method of claim 1 wherein the mild base is sodium bicarbonate.
Claim 11
Independent Claim
126 words
The method of purifying extracts containing biologically active materials obtained from a species of the zoapatle plant selected from Montanoa tomentosa and Montanoa floribunda which comprises the steps of: dissolving the crude extract in a lower aliphatic ether, washing the solution with an aqueous solution of a mild base and separating the organic phase from the aqueous phase, chromatographing the solution through a column of adsorbent material, eluting the column with a mixture of a polar and a non-polar solvent, combining the fractions containing the biologically active materials and removing the solvent therefrom, dissolving the residue in an aromatic hydrocarbon, chromatographing the solution through a column of a polymeric gel, eluting the column with an aromatic hydrocarbon and collecting the fractions containing the biologically active materials.
Claim 12
Independent Claim
126 words
The method of purifying extracts containing biologically active materials obtained from a species of the zoapatle plant selected from Montanoa tomentosa and Montanoa floribunda which comprises the steps of: dissolving the crude extract in a lower aliphatic ether, washing the solution with an aqueous solution of a mild base and separating the organic phase from the aqueous phase, chromatographing the solution through a column of adsorbent material, eluting the column with a mixture of a polar and a non-polar solvent, combining the fractions containing the biologically active materials and removing the solvent therefrom, dissolving the residue in an aromatic hydrocarbon, chromatographing the solution through a column of a polymeric gel, eluting the column with an aromatic hydrocarbon and collecting the fractions containing the biologically active materials.
Claim 13
Dependent Claim
12 words
The method of claim 10 wherein the zoapatle plant is Montanoa tomentosa.
Claim 14
Dependent Claim
12 words
The method of claim 10 wherein the aliphatic ether is diethyl ether.
Claim 15
Dependent Claim
15 words
The method of claim 10 wherein the adsorbent material is silicic acid or silica gel.
Claim 16
Dependent Claim
17 words
The method of claim 10 wherein the mixture of polar and non-polar solvents comprises chloroform and isopropanol.
Claim 17
Dependent Claim
11 words
The method of claim 10 wherein the aromatic hydrocarbon is benzene.
Claim 18
Dependent Claim
13 words
The method of claim 10 wherein the polymeric gel is vinyl acetate copolymer.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-12-18 | 1982-06-19 | 1982-12-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-12-18 | 1986-06-19 | 1986-12-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-12-18 | 1990-06-19 | 1990-12-19 | $7700.00 | Window Closed / Lapsed |