US4127717A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Benzo-cyclitolamines
Assignee: ER Squibb and Sons LLC
•
Filing: 1978-03-20
•
Granted: 1978-11-28
•
Expires: 1998-03-20
Abstract
Abstract Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein n is 1 or 2; m is 2, 3 or 4; R 1 is alkanoyl; and R 2 is a tertiary amino group; have hypotensive activity.
Inventors
- 👤 Frederic P. Hauck
- 👤 Joyce Reid
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 21:11
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/096; A; A61; A61P; A61P9/00; A61P9/12
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
57 words
A compound having the formula ##STR9## or a pharmaceutically acceptable salt thereof, wherein R 1 is alkanoyl having 2 to 7 carbon atoms; R 2 is dialkylamino, 1-pyrrolidinyl, 1-piperidinyl, 4-alkyl-1-piperazinyl, or 4-morpholinyl; n is 1 or 2; and m is 2, 3 or 4; wherein the term "alkyl" refers to groups having 1 to 6 carbon atoms.
Claim 2
Dependent Claim
57 words
A compound having the formula ##STR9## or a pharmaceutically acceptable salt thereof, wherein R 1 is alkanoyl having 2 to 7 carbon atoms; R 2 is dialkylamino, 1-pyrrolidinyl, 1-piperidinyl, 4-alkyl-1-piperazinyl, or 4-morpholinyl; n is 1 or 2; and m is 2, 3 or 4; wherein the term "alkyl" refers to groups having 1 to 6 carbon atoms.
Claim 3
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 1 is acetyl.
Claim 4
Dependent Claim
16 words
A compound in accordance with claim 2 wherein the R 1 O-- groups are axially oriented.
Claim 5
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 2 is dialkylamino.
Claim 6
Dependent Claim
12 words
A compound in accordance with claim 4 wherein R 2 is dimethylamino.
Claim 7
Dependent Claim
16 words
A compound in accordance with claim 1 wherein R 2 is 1-pyrrolidinyl, 1-piperidinyl, 4-alkyl-1-piperazinyl, or 4-morpholinyl.
Claim 8
Dependent Claim
11 words
A compound in accordance with claim 1 wherein n is 1.
Claim 9
Dependent Claim
11 words
A compound in accordance with claim 1 wherein n is 2.
Claim 10
Dependent Claim
10 words
The compound in accordance with claim 1, 2,3:4a,11a-trans-5-[3-(dimethylamino)propyl]-1,2,3,4,10,11-hexahydro-5H-dibenzo[a,d]cycloheptene-2,3,4a,11a-tetrol, tetraacetate ester.
Claim 11
Dependent Claim
10 words
The compound in accordance with claim 1, 2,3:4a,9a-trans-9-[3-(dimethylamino)ethyl]-1,2,3,4,4a,-9,9a,10-octahydro-2,3,4a,9a-anthracenetetrol, tetraacetate ester.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-11-27 | 1982-05-29 | 1982-11-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-11-27 | 1986-05-29 | 1986-11-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-11-27 | 1990-05-29 | 1990-11-28 | $7700.00 | Window Closed / Lapsed |