US3971823A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cyclitolamines
Assignee: ER Squibb and Sons LLC
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Filing: 1975-12-02
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Granted: 1976-07-27
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Expires: 1995-12-02
Abstract
Abstract Compounds having the structure ##SPC1## Wherein R 1 is alkyl or arylalkyl; R 2 is hydrogen, halogen, alkyl, or alkoxy; R 3 is alkanoyl; R 4 is hydrogen or alkanoyl; n is 1, 2 or 3; m is 1, 2, 3 or 4; and p is 2, 3 or 4; are useful for the treatment of hypertension.
Inventors
- 👤 Frederic P. Hauck
- 👤 Joseph E. Sundeen
- 👤 Joyce Reid
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 23:51
CPC Classifications
C; C07; C07C; C07C233/00
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
113 words
A compound having the structure ##SPC10## or a pharmaceutically acceptable salt thereof, wherein R 1 is alkyl, phenylalkyl or phenylalkyl wherein the ring is substituted by 1 or 2 groups selected from the group of halogen, alkyl or alkoxy having 1-6 carbon atoms, said alkyl moieties having 1-6 carbon atoms; R 2 is hydrogen, halogen, alkyl, or alkoxy; R 3 is alkanoyl having 1-7 carbon atoms; R 4 is hydrogen or alkanoyl having 1-7 carbon atoms; n is 1, 2 or 3; m is 1, 2, 3 or 4; and p is 2, 3 or 4; with the proviso that when R 4 is alkanoyl, R 3 and R 4 are the same.
Claim 2
Dependent Claim
113 words
A compound having the structure ##SPC10## or a pharmaceutically acceptable salt thereof, wherein R 1 is alkyl, phenylalkyl or phenylalkyl wherein the ring is substituted by 1 or 2 groups selected from the group of halogen, alkyl or alkoxy having 1-6 carbon atoms, said alkyl moieties having 1-6 carbon atoms; R 2 is hydrogen, halogen, alkyl, or alkoxy; R 3 is alkanoyl having 1-7 carbon atoms; R 4 is hydrogen or alkanoyl having 1-7 carbon atoms; n is 1, 2 or 3; m is 1, 2, 3 or 4; and p is 2, 3 or 4; with the proviso that when R 4 is alkanoyl, R 3 and R 4 are the same.
Claim 3
Dependent Claim
11 words
A compound in accordance with claim 1 wherein n is 1.
Claim 4
Dependent Claim
11 words
A compound in accordance with claim 1 wherein n is 2.
Claim 5
Dependent Claim
11 words
A compound in accordance with claim 1 wherein n is 3.
Claim 6
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 1 is alkyl.
Claim 7
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 1 is methyl.
Claim 8
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 3 is acetyl.
Claim 9
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 4 is hydrogen.
Claim 10
Dependent Claim
12 words
A compound in accordance with claim 2 wherein R 4 is alkanoyl.
Claim 11
Dependent Claim
17 words
A compound in accordance with claim 2 wherein R 1 is methyl, and R 3 is acetyl.
Claim 12
Dependent Claim
21 words
A compound in accordance with claim 10 wherein m and p are the same or different and are 2 or 3.
Claim 13
Dependent Claim
14 words
The compound in accordance with claim 2 having the name 3a, 7a-trans-5,6-trans-1-[3-[[3-(p-acetylphenoxy)propyl]-methylamino]propyl]hexahydro-3a,5,6,7a-indantetrol, tetraacetate ester.
Claim 14
Dependent Claim
13 words
The compound in accordance with claim 2 having the name 3a,7a-trans-5,6-trans-1-[3-[[2-(o-ethoxyphenoxy)ethyl]-methylamino]propyl]hexahydro-3a,5,6,7a-indantetrol, tetraacetate ester.
Claim 15
Dependent Claim
13 words
The compound in accordance with claim 2 having the name 3a,7a-trans-5,6-trans-1-[3-[[2-(p-acetylphenoxy)ethyl]-methylamino]propyl]hexahydro-3a,5,6,7a-indantetrol, tetraacetate ester.
Claim 16
Dependent Claim
13 words
The compound in accordance with claim 2 having the name, 3a,7a-trans-5,6-trans-hexahydro-1-[3-[methyl(3-phenoxypropyl)amino]propyl]-3a,5,6,7a-indantetrol, tetraacetate ester.
Claim 17
Dependent Claim
77 words
A compound having the structure ##SPC11## wherein R 1 is alkyl, phenylalkyl or phenylalkyl wherein the ring is substitued by 1 or 2 groups selected from the group of halogen, alkyl or alkoxy having 1-6 carbon atoms, said alkyl moieties having 1-6 carbon atoms; R 2 is hydrogen, halogen, alkyl, alkoxy or alkanoyl having 1-7 carbon atoms; n is 1, 2 or 3; m is 1, 2, 3 or 4; and p is 2, 3 or 4.
Claim 18
Dependent Claim
77 words
A compound having the structure ##SPC11## wherein R 1 is alkyl, phenylalkyl or phenylalkyl wherein the ring is substitued by 1 or 2 groups selected from the group of halogen, alkyl or alkoxy having 1-6 carbon atoms, said alkyl moieties having 1-6 carbon atoms; R 2 is hydrogen, halogen, alkyl, alkoxy or alkanoyl having 1-7 carbon atoms; n is 1, 2 or 3; m is 1, 2, 3 or 4; and p is 2, 3 or 4.
Claim 19
Dependent Claim
11 words
A compound in accordance with claim 16 wherein n is 1.
References Cited (Backward Citations)
US3159634A
Cited
US3894031A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-07-27 | 1980-01-26 | 1980-07-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-07-27 | 1984-01-26 | 1984-07-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-07-27 | 1988-01-26 | 1988-07-27 | $7700.00 | Window Closed / Lapsed |