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US4118468A
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Technetium-99m-labelled diagnostic agent for kidney scanning and process for its manufacture
Assignee: Hoechst AG
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Filing: 1976-11-12
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Granted: 1978-10-03
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Expires: 1996-11-12
Abstract
Abstract A diagnostic agent for the visualization of the kidneys is disclosed as well as a process for its manufacture. The new agent consists of pyrrolidinomethyl-tetracycline in a buffer solution, a tin(II) salt and technetium-99m in physiological sodium chloride solution.
Inventors
- 👤 Helmut Strecker
- 👤 Reinhard Kasmarker
- 👤 Gerhard Kloss
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 03:27
CPC Classifications
A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; A61K2123/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
84 words
A method for making a diagnostic agent for visualization of the kidneys, which method comprises mixing a buffer solution of pyrrolidinomethyl-tetracycline, said solution having an initial pH between 5.0 and 6.5, with a tin (II)-salt in a molar ratio of 10 to 100 mols of pyrrolidinomethyl-tetracycline per gram atom of tin (II) to give a first mixture, and then combining said first mixture with technetium-99m pertechnate in physiological sodium chloride solution to yield a second mixture having a final pH from 4 to 8.
Claim 2
Independent Claim
84 words
A method for making a diagnostic agent for visualization of the kidneys, which method comprises mixing a buffer solution of pyrrolidinomethyl-tetracycline, said solution having an initial pH between 5.0 and 6.5, with a tin (II)-salt in a molar ratio of 10 to 100 mols of pyrrolidinomethyl-tetracycline per gram atom of tin (II) to give a first mixture, and then combining said first mixture with technetium-99m pertechnate in physiological sodium chloride solution to yield a second mixture having a final pH from 4 to 8.
Claim 3
Dependent Claim
30 words
The method as in claim 1 wherein the molar ratio of pyrrolidinomethyl-tetracycline to tin (II) in said first mixture is 30 to 50 mols per gram atom of tin (II).
Claim 4
Dependent Claim
19 words
The method as in claim 1 wherein the final pH in said second mixture is from 6.5 to 7.5.
Claim 5
Dependent Claim
23 words
The method as in claim 1 wherein said buffer solution contains from 0.8 to 1.2 mols of phosphate buffer per mol of pyrrolidinomethyl-tetracycline.
Claim 6
Dependent Claim
19 words
The method as in claim 1 wherein said first mixture is lyophilized before being combined with said technetium-99m pertechnate.
Claim 7
Dependent Claim
17 words
The method as in claim 5 wherein the lyophilized first mixture is under an inert protective gas.
Claim 8
Dependent Claim
60 words
A diagnostic agent for visualization of the kidneys, said agent consisting of a mixture, having a pH from 6.5 to 7.5, of a buffer solution of pyrrolidinomethyl-tetracycline, a tin (II) salt in a ratio of 10 to 100 mols of pyrrolidinomethyl-tetracycline per gram atom of tin (II), and of a solution of a technetium-99m pertechnate in physiological sodium chloride solution.
Claim 9
Dependent Claim
60 words
A diagnostic agent for visualization of the kidneys, said agent consisting of a mixture, having a pH from 6.5 to 7.5, of a buffer solution of pyrrolidinomethyl-tetracycline, a tin (II) salt in a ratio of 10 to 100 mols of pyrrolidinomethyl-tetracycline per gram atom of tin (II), and of a solution of a technetium-99m pertechnate in physiological sodium chloride solution.
Claim 10
Dependent Claim
65 words
A kit for preparing, by the addition thereto of a physiological sodium chloride solution of technetium-99 m pertechnate, a diagnostic for visualization of the kidneys, said kit comprising a contained mixture of a tin (II) salt with a buffer solution of pyrrolidinomethyl-tetracycline having an initial pH from 5.0 to 6.5, said mixture containing 10 to 100 mols of pyrrolidinomethyl-tetracycline per gram atom of tin (II).
Claim 11
Dependent Claim
65 words
A kit for preparing, by the addition thereto of a physiological sodium chloride solution of technetium-99 m pertechnate, a diagnostic for visualization of the kidneys, said kit comprising a contained mixture of a tin (II) salt with a buffer solution of pyrrolidinomethyl-tetracycline having an initial pH from 5.0 to 6.5, said mixture containing 10 to 100 mols of pyrrolidinomethyl-tetracycline per gram atom of tin (II).
Claim 12
Dependent Claim
12 words
A kit as in claim 8 wherein said contained mixture is lyophilized.
Claim 13
Dependent Claim
17 words
A kit as in claim 9 wherein said lyophilized contained mixture is under an inert protective gas.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-02 | 1982-04-03 | 1982-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-02 | 1986-04-03 | 1986-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-02 | 1990-04-03 | 1990-10-03 | $7700.00 | Window Closed / Lapsed |