US4101548A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1,2,3-Thiadiazole amides
Assignee: Bristol Myers Co
•
Filing: 1977-02-22
•
Granted: 1978-07-18
•
Expires: 1997-02-22
Abstract
Abstract A series of novel 4-amino-2-(thiadiazole-carbonyl piperazinyl)-6,7-dimethoxyquinazolines is disclosed having antihypertensive properties. The thiadiazole substituent may be optionally substituted with alkyl or lower alkoxy carbonylamino groups. A representative embodiment of the invention is 4-amino-6,7-dimethoxy-2-[4-(5-ethoxy-carbonylamino-1,2,3-thiadiazole-4-carbonyl)-piperazin-1-yl]-quinazoline.
Inventors
- 👤 Ronnie R. Crenshaw
- 👤 Richard A. Partyka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 21:40
CPC Classifications
C; C07; C07D; C07D285/00; C07D285/01; C07D285/02; C07D285/04; C07D285/06
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
46 words
A compound having the formula ##STR26## or a pharmaceutically acceptable salt thereof wherein R 1 is hydrogen, amino, lower alkyl of 1 to 4 carbon atoms inclusive or NHCO 2 R 2 in which R 2 is lower alkyl of 1 to 4 carbon atoms inclusive.
Claim 2
Dependent Claim
46 words
A compound having the formula ##STR26## or a pharmaceutically acceptable salt thereof wherein R 1 is hydrogen, amino, lower alkyl of 1 to 4 carbon atoms inclusive or NHCO 2 R 2 in which R 2 is lower alkyl of 1 to 4 carbon atoms inclusive.
Claim 3
Dependent Claim
9 words
The compound defined in claim 1 which is 4-amino-6,7-dimethoxy-2-[4-(1,2,3-thiadiazole-4-carbonyl)piperazin-1-yl]-quinazoline.
Claim 4
Dependent Claim
9 words
The compound defined in claim 2 which is 4-amino-6,7-dimethoxy-2-[4-(1,2,3-thiadiazole-5-carbonyl)piperazin-1-yl]-quinazoline.
Claim 5
Dependent Claim
35 words
The compound of claim 1 in which the thiadiazine radical is attached in the 4-ring position to the carbonyl functionality and R 1 is NHCO 2 R 2 in which R 2 is lower alkyl.
Claim 6
Dependent Claim
9 words
The compound defined in claim 4 which is 4-amino-6,7-dimethoxy-2-[4-(5-ethoxycarbonylamino-1,2,3-thiadiazol-4-carbonyl)piperazin-1-yl]-quinazoline.
Claim 7
Dependent Claim
10 words
The compound defined in claim 4 which is 4-amino-6,7-dimethoxy-2-[4-(5-ethoxycarbonylamino-1,2,3-thiadiazole-4-carbonyl)piperazin-1-yl]quinazoline hydrochloride.
References Cited (Backward Citations)
US2663706A
Cited
US3812127A
Cited
US3517005A
Cited
US3511836A
Cited
US3635979A
Cited
US3594980A
Cited
US3669968A
Cited
US3769286A
Cited
US3780040A
Cited
US3920636A
Cited
US4001238A
Cited
US4001237A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-17 | 1982-01-16 | 1982-07-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-17 | 1986-01-16 | 1986-07-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-17 | 1990-01-16 | 1990-07-18 | $7700.00 | Window Closed / Lapsed |