US3669968A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Trialkoxy quinazolines
Assignee: Pfizer Inc
•
Filing: 1970-05-21
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Granted: 1972-06-13
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Expires: 1990-05-21
Abstract
Abstract A series of novel 2-substituted-4-amino-6,7,8trialkoxyquinazolines have been prepared, including their acid addition salts. These compounds are useful in therapy as potent antihypertensive agents. Methods for their preparation are described in detail, including various synthetic routes leading to the required novel intermediates.
Inventors
- 👤 Hans-Jurgen E Hess
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 12:53
CPC Classifications
C; C07; C07D; C07D239/00; C07D239/70; C07D239/72; C07D239/95; C07D239/96
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
11 words
A compound as claimed in claim 1 wherein Z is monoalkylamino.
Claim 2
Dependent Claim
11 words
A compound as claimed in claim 1 wherein Z is di-alkylamino.
Claim 3
Dependent Claim
1 words
2-(N-Monomethylamino)-4-amino-6,7,8-trimethoxyquinazoline.
Claim 4
Dependent Claim
1 words
2-(N,N-Dimethylamino)-4-amino-6,7,8-trimethoxyquinazoline.
Claim 5
Dependent Claim
15 words
A compound as claimed in claim 1 wherein Z is N-substituted piperazino of the formula:
Claim 6
Dependent Claim
11 words
A compound as claimed in claim 6 wherein R is furyl.
Claim 7
Dependent Claim
11 words
A compound as claimed in claim 6 wherein R is thienyl.
Claim 8
Dependent Claim
17 words
A compound as claimed in claim 6 wherein R is alkenyloxy having up to five carbon atoms.
Claim 9
Dependent Claim
18 words
A compound as claimed in claim 6 wherein R is alkoxy having from one to six carbon atoms.
Claim 10
Dependent Claim
18 words
A compound as claimed in claim 6 wherein R is hydroxyalkoxy having from two to six carbon atoms.
Claim 11
Dependent Claim
1 words
2-(4-(2-Furoyl)-1-piperazinyl)-4-amino-6,7,8-trimethoxyquinazoline.
Claim 12
Dependent Claim
2 words
2-Methallyl 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)-1-piperazinecarboxylate.
Claim 13
Dependent Claim
2 words
Isobutyl 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)-1-piperazinecarboxylate.
Claim 14
Dependent Claim
2 words
2-Methyl-2-hydroxypropyl 4-(4-amino-6,7,8-trimethoxyquinazoline-2-yl)-1-piperazinecarboxylate.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1975-06-13 | 1975-12-13 | 1976-06-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1979-06-13 | 1979-12-13 | 1980-06-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1983-06-13 | 1983-12-13 | 1984-06-13 | $7700.00 | Window Closed / Lapsed |