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US4091024A
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Pyrrolidine and piperidine-2-carboxylic acid derivatives
Assignee: ER Squibb and Sons LLC
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Filing: 1976-12-03
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Granted: 1978-05-23
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Expires: 1996-12-03
Abstract
Abstract New derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
Inventors
- 👤 Miguel Angel Ondetti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:15
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/64; A; A61; A61P; A61P9/00; A61P9/12; C07C; C07C327/00; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16; C07D207/46; C07D209/00; C07D209/02; C07D209/04; C07D209/10; C07D209/18; C07D209/20; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/60
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
101 words
A compound of the formula ##STR10## and salts thereof, wherein R is hydroxy or lower alkoxy; R 1 is hydrogen, lower alkanoyl, benzoyl or ##STR11## A and B together form a (CH 2 ) p bridge which completes an unsubstituted ring of 5 or 6 atoms with the nitrogen and carbon to which they are joined or said ring substituted with a hydroxy group; X is carboxy, lower alkoxycarbonyl, carbamoyl, N-substituted carbamoyl wherein N-substituent is lower alkyl or phenyl-lower alkylene, or cyano: m is 0 or 1; n is 0, 1, 2, 3 or 4; and p is 3 or 4.
Claim 2
Dependent Claim
101 words
A compound of the formula ##STR10## and salts thereof, wherein R is hydroxy or lower alkoxy; R 1 is hydrogen, lower alkanoyl, benzoyl or ##STR11## A and B together form a (CH 2 ) p bridge which completes an unsubstituted ring of 5 or 6 atoms with the nitrogen and carbon to which they are joined or said ring substituted with a hydroxy group; X is carboxy, lower alkoxycarbonyl, carbamoyl, N-substituted carbamoyl wherein N-substituent is lower alkyl or phenyl-lower alkylene, or cyano: m is 0 or 1; n is 0, 1, 2, 3 or 4; and p is 3 or 4.
Claim 3
Dependent Claim
43 words
A compound as in claim 1 wherein R is hydroxy; R 1 is hydrogen or lower alkanoyl; X is lower alkoxycarbonyl or carbamoyl; A and B join to complete a 5- or 6-membered ring; m is 1 and n is 1 or 2.
Claim 4
Dependent Claim
26 words
A compound of the formula ##STR12## and salts thereof, wherein R, R 1 , X, m and n have the same meaning as in claim 1.
Claim 5
Dependent Claim
26 words
A compound of the formula ##STR13## and salts thereof, wherein R, R 1 , X, m and n have the same meaning as in claim 2.
Claim 6
Dependent Claim
15 words
A compound as in claim 1 wherein ##STR14## is the radical of proline or hydroxyproline.
Claim 7
Dependent Claim
20 words
A compound as in claim 1 wherein A and B together are --(CH 2 ) 4 completing a six-membered ring.
Claim 8
Dependent Claim
11 words
A compound as in claim 1 wherein R 1 is ##STR15##
Claim 9
Dependent Claim
10 words
A compound as in claim 1 wherein X is carboxy.
Claim 10
Dependent Claim
11 words
A compound as in claim 1 wherein X is lower alkoxycarbonyl.
Claim 11
Dependent Claim
10 words
A compound as in claim 1 wherein X is carbamoyl.
Claim 12
Dependent Claim
10 words
A compound as in claim 1 wherein X is cyano.
Claim 13
Dependent Claim
24 words
A compound as in claim 3 wherein R is hydroxy; R 1 is hydrogen; X is methoxycarbonyl; and m and n each is 1.
Claim 14
Dependent Claim
24 words
A compound as in claim 3 wherein R is hydroxy; R 1 is hydrogen; X is carbamoyl; and n and m each is 1.
Claim 15
Dependent Claim
24 words
A compound as in claim 3 wherein R is hydroxy; R 1 is hydrogen; X is cyano; and m and n each is 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-05-22 | 1981-11-21 | 1982-05-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-05-22 | 1985-11-21 | 1986-05-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-05-22 | 1989-11-21 | 1990-05-23 | $7700.00 | Window Closed / Lapsed |