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US4082734A
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US
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Production of intravenously applicable native human immune globulin having a normal half-life
Assignee: Biotest Serum Institut GmbH
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Filing: 1976-05-19
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Granted: 1978-04-04
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Expires: 1996-05-19
Abstract
Abstract An intravenously applicable native human immune globulin of normal half-life, unchanged antibody activity and free from anti-complement activity, is produced by heating human plasma or serum for about 1/2 to 4 hours at about 50° to 60° C, followed by conventional fractionation.
Inventors
- 👤 Wolfgang Stephan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 14:27
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/06; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83; Y10S530/831
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
66 words
A method of preparing an intravenously applicable native-human immune globulin of substantially unchanged half-life and antibody activity but free from anti-complement activity, comprising heating human plasma or human serum for about 2 to 4 hours at about 50° to 56° C, and then fractionating, the heating having been long enough within the recited parameters so that the product upon fractionation is substantially free from anti-complement activity.
Claim 2
Independent Claim
66 words
A method of preparing an intravenously applicable native-human immune globulin of substantially unchanged half-life and antibody activity but free from anti-complement activity, comprising heating human plasma or human serum for about 2 to 4 hours at about 50° to 56° C, and then fractionating, the heating having been long enough within the recited parameters so that the product upon fractionation is substantially free from anti-complement activity.
Claim 3
Dependent Claim
12 words
A method according to claim 1, wherein fractionation is effected with alcohol.
Claim 4
Dependent Claim
13 words
A method according to claim 1, wherein fractionation is effected with ammonium sulfate.
Claim 5
Dependent Claim
18 words
A method according to claim 1, wherein heating is effected for about 2 hours at about 56° C.
Claim 6
Dependent Claim
14 words
An intravenously applicable native human immune globulin produced by the process of claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-03 | 1981-10-03 | 1982-04-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-03 | 1985-10-03 | 1986-04-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-03 | 1989-10-03 | 1990-04-04 | $7700.00 | Window Closed / Lapsed |