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US4080471A
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Use of substituted isopropylaminopropanols for inducing inotropic effects of the human heart
Assignee: AstraZeneca AB
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Filing: 1976-06-25
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Granted: 1978-03-21
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Expires: 1996-06-25
Abstract
Abstract A method for inducing increased inotropic effects of the human heart without inducing arrhythmogenic effects, but providing an antiarrhythmogenic effect therein. The method is effected by administering to mammals, including man, a compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen or ##STR2## wherein R' is selected from the group consisting of straight or branched aliphatic alkyl having 1 to 7 carbon atoms, phenyl, benzyl, and phenylethyl, wherein the phenyl nucleus may be further substituted with alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, alkoxyalkyl having 2 to 8 carbon atoms or halogen, in any position.
Inventors
- 👤 Enar Ingemar Carlsson
- 👤 Nils Henry Alfons Persson
- 👤 Gustav Benny Roger Samuelsson
- 👤 Kjell Ingvar Leopold Wetterlin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 19:51
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135; A61K31/21; A61K31/215; A61K31/22; A61K31/23; A61K31/235
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
119 words
The method of inducing increased inotropic effects of the human heart without inducing arrhythmogenic effects but providing an antiarrhythmogenic effect therein by administering to humans, suffering from too low heart inotropy in an amount sufficient to induce increased inotropic effects of the heart, a compound of the formula ##STR5## wherein R is selected from the group consisting of hydrogen or ##STR6## wherein R' is selected from the group consisting of straight or branched aliphatic alkyl having 1 to 7 carbon atoms, phenyl, benzyl, and phenylethyl, wherein the phenyl nucleus may be further substituted with alkyl having 1 to 4 carbon atoms, alkoxyalkyl having 2 to 8 carbon atoms or halogen, in any position, or a therapeutically acceptable salt thereof.
Claim 2
Independent Claim
119 words
The method of inducing increased inotropic effects of the human heart without inducing arrhythmogenic effects but providing an antiarrhythmogenic effect therein by administering to humans, suffering from too low heart inotropy in an amount sufficient to induce increased inotropic effects of the heart, a compound of the formula ##STR5## wherein R is selected from the group consisting of hydrogen or ##STR6## wherein R' is selected from the group consisting of straight or branched aliphatic alkyl having 1 to 7 carbon atoms, phenyl, benzyl, and phenylethyl, wherein the phenyl nucleus may be further substituted with alkyl having 1 to 4 carbon atoms, alkoxyalkyl having 2 to 8 carbon atoms or halogen, in any position, or a therapeutically acceptable salt thereof.
Claim 3
Dependent Claim
16 words
The method according to claim 1, wherein 1-isopropylamino-3-(p-hydroxyphenoxy)-propanol-2, or a therapeutically acceptable salt thereof is administered.
Claim 4
Dependent Claim
16 words
The method according to claim 1, wherein 1-isopropylamino-3-(p-isobutyryloxyphenoxy)-propanol-2 or a therapeutically acceptable salt thereof is administered.
Claim 5
Dependent Claim
16 words
The method according to claim 1, wherein 1-isopropylamino-3-(p-benzoyloxyphenoxy)-propanol-2 or a therapeutically acceptable salt thereof is administered.
Claim 6
Dependent Claim
16 words
The method according to claim 1, wherein 1-isopropylamino-3-(p-pivaloyloxyphenoxy)-propanol-2 or a therapeutically acceptable salt thereof is administered.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-20 | 1981-09-19 | 1982-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-20 | 1985-09-19 | 1986-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-20 | 1989-09-19 | 1990-03-21 | $7700.00 | Window Closed / Lapsed |