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US4058550A
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Polysubstituted-alkyl esters of 4-alkylaminobenzoic acids
Assignee: Wyeth Holdings LLC
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Filing: 1975-10-28
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Granted: 1977-11-15
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Expires: 1995-10-28
Abstract
Abstract Polysubstituted-alkyl esters of 4-alkylaminobenzoic acids having hypolipemic activity.
Inventors
- 👤 Robert Gordon Shepherd
- 👤 Thomas Gary Miner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 15:50
CPC Classifications
C; C07; C07H; C07H13/00; C07H13/02; C07H13/08; C07D; C07D303/00; C07D303/02; C07D303/12; C07D303/16; C07D319/00; C07D319/04; C07D319/06
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
133 words
A compound of the formula: ##STR4## wherein R 4 is an unbranched or branched alkyl group, C n H 2n+1 wherein n is 8 to 19; R 1 , R 2 and R 3 are selected from the group consisting of hydrogen, C 1 -C 3 alkyl, and C 1 -C 3 hydroxyalkylene; X and Y, which may be the same or different, are selected from the group consisting of hydrogen, hydroxy, lower alkanoyloxy, hydroxymethyl, and when taken together X and Y can comprise a carbon-carbon bond; wherein the 4-alkylaminobenzoyloxy moiety and X may be interchanged; with the proviso that when R 1 , R 2 and R 3 are all hydrogen or C 1 -C 3 alkyl, then X and Y may not both be hydrogen; and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
133 words
A compound of the formula: ##STR4## wherein R 4 is an unbranched or branched alkyl group, C n H 2n+1 wherein n is 8 to 19; R 1 , R 2 and R 3 are selected from the group consisting of hydrogen, C 1 -C 3 alkyl, and C 1 -C 3 hydroxyalkylene; X and Y, which may be the same or different, are selected from the group consisting of hydrogen, hydroxy, lower alkanoyloxy, hydroxymethyl, and when taken together X and Y can comprise a carbon-carbon bond; wherein the 4-alkylaminobenzoyloxy moiety and X may be interchanged; with the proviso that when R 1 , R 2 and R 3 are all hydrogen or C 1 -C 3 alkyl, then X and Y may not both be hydrogen; and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
84 words
A compound according to claim 1, wherein R 4 is an unbranched or branched alkyl group, C n H 2n+1 wherein n is 8 to 19; R 1 , R 2 and R 3 are hydrogen; X and Y, which may be the same of different, are selected from the group consisting of hydroxy or lower alkanoyloxy, and, when taken together X and Y can comprise a carbon-carbon bond wherein the 4-alkylaminobenzoyloxy moiety and X may be interchanged; and the pharmaceutically acceptable salts thereof.
Claim 4
Dependent Claim
8 words
The compound according to claim 1, 2,3-dihydroxypropyl 4-(n-hexadecylamino)benzoate.
Claim 5
Dependent Claim
9 words
The compound according to claim 1, 2,3-dihydroxypropyl 4-(n-hexadecylamino)benzoate hydrochloride.
Claim 6
Dependent Claim
8 words
The compound according to claim 1, 2-acetoxy-3-hydroxypropyl 4-(n-hexadecylamino)benzoate.
Claim 7
Dependent Claim
8 words
The compound according to claim 1, 1,3-dihydroxy-2-propyl 4-(n-hexadecylamino)benzoate.
Claim 8
Dependent Claim
8 words
The compound according to claim 1, 4-hydroxybutyl 4-(n-hexadecylamino)benzoate.
Claim 9
Dependent Claim
8 words
The compound according to claim 1, 3-hydroxypropyl 4-(n-hexadecylamino)benzoate.
Claim 10
Dependent Claim
7 words
The compound according to claim 1, 2-hydroxypropyl-4-(n-hexadecylamino)benzoate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-11-14 | 1981-05-16 | 1981-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-11-14 | 1985-05-16 | 1985-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-11-14 | 1989-05-16 | 1989-11-15 | $7700.00 | Window Closed / Lapsed |