Glyceryl-n-(substituted phenyl) anthranilates
Abstract
Abstract The invention relates to glyceryl esters of N-X,Y,Z-phenyl (anthranilic acids), to their use as analgesic anti-inflammatory agents, and to the intermediates useful in the preparation thereof. Illustrative of the preparation of those compounds is the formation of glyceryl-N-(3-trifluoromethylphenyl) anthranilate, as follows: Reflux a mixture containing N-(3trifluoromethylphenyl) anthranilic acid, chloroacetonitrile in the presence of triethylamine to produce cyanomethyl-N-(3trifluoromethylphenyl) anthranilate which, by heating with 2,2dimethyl-1,3-dioxolane-4-methanol in the presence of anhydrous potassium carbonate, produces Beta - gamma isopropylidenedioxypropyl anthranilate. Hydrolysis of the Beta gamma -isopropylidenedioxypropyl-N-(3-trifluoromethylphenyl) anthranilate with 75 percent acetic acid for 35 minutes yields glyceryl N-(3-trifluoromethylphenyl) anthranilate. Alternate methods for the preparation of the glyceryl esters of N-(X,Y,Zphenyl) anthranilic acids are also described.
Inventors
- 👤 Margaret H Sherlock
Bibliographic Details
Claims Analysis
Total Claims: 6References Cited (Backward Citations)
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