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US4056529A
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Dibenzopyrimidoazepines
Assignee: John Wyeth and Brother Ltd
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Filing: 1976-01-08
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Granted: 1977-11-01
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Expires: 1996-01-08
Abstract
Abstract The invention relates to dibenzopyrimidoazepines of the formula (I) ##STR1## and their acid addition and quaternary ammonium salts. In formula (I) R 1 and R 2 each represent hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl and X represents two hydrogen atoms, an oxo group, a protected oxo group or an oximino group. The compounds in which X represents two hydrogen atoms, an oxo group or an oximino group possess hypoglycaemic activity. The compound in which X represents a protected oxo group are intermediates for preparing the compounds in which X is an oxo group. The dibenzopyrimidoazepines may be prepared by cyclising or cyclodehydrating novel morphanthridine derivatives.
Inventors
- 👤 Robin Michael Black
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 20:03
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04; C07D223/00; C07D223/14; C07D223/18; C07D223/20; C07D491/00; C07D491/02; C07D491/10; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
63 words
A dibenzopyrimidoazepine selected from the group consisting of compounds having the formula (I): ##STR10## and the pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein R 1 and R 2 each represent hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl and X represents two hydrogen atoms, an oxo group, an ethylene ketal group, a di-(lower alkyl) ketal group, or an oximino group.
Claim 2
Dependent Claim
63 words
A dibenzopyrimidoazepine selected from the group consisting of compounds having the formula (I): ##STR10## and the pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, wherein R 1 and R 2 each represent hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl and X represents two hydrogen atoms, an oxo group, an ethylene ketal group, a di-(lower alkyl) ketal group, or an oximino group.
Claim 3
Dependent Claim
51 words
A dibenzopyrimidoazepine according to claim 1 of the formula (II) ##STR11## or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof wherein R 1 and R 2 each represent hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl and Y represents two hydrogen atoms, an oxo group or an oximino group.
Claim 4
Dependent Claim
21 words
A dibenzopyrimidoazepine according to claim 2 wherein R 1 and R 2 each represents hydrogen, lower alkyl, lower alkoxy or halogen.
Claim 5
Dependent Claim
10 words
A dibenzopyrimidoazepine according to claim 1 which is 3,4-dihydrodibenzo[c,f]pyrimido[1,2-a] azepin-10(2H)-one.
Claim 6
Dependent Claim
10 words
a dibenzopyrimidoazepine according to claim 1 which is 10-oximino-3,4-dihydro[2H]dibenzo[c,f] pyrimido[1,2-a]azepine.
Claim 7
Dependent Claim
11 words
A dibenzopyrimidoazepine according to claim 1 which is 3,4-dihydro[2H, 10H]dibenzo[c,f]pyrimido [1,2-a]azepine.
References Cited (Backward Citations)
US3646009A
Cited
US3892695A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-31 | 1981-05-02 | 1981-11-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-31 | 1985-05-02 | 1985-11-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-31 | 1989-05-02 | 1989-11-01 | $7700.00 | Window Closed / Lapsed |