Anti-diabetically active sulfonyl-semicarbazides

Abstract

Abstract NOVEL SULFONYL UREAS AND SULFONYL-SEMICARBAZIDES HAVING THE FORMULA: 1-((-1,2-PHENYLENE-X-(R1-1,2-PHENYLENE)-)>Y-CO-NH-Z-), 4-(R2-NH-CO-NH-SO2-)BENZENE WHEREIN X REPRESENTS OXYGEN, SULFUR SATURATED, UNSTAURATED, STRAIGHT OR BRANCHED CHAIN ALKYLENE CONTAINING UP TO 3 CARBON ATOMS, OXYMETHYLENE, THIAMETHYLENE, THIAETHYLENE, IMINOMETHYLENE, ALKYLATED IMINOMETHYLENE, ACYLATED MINOMETHYLENE, CARBOXIMIDO, ALKYLATED CARBOXIMIDO, OR A VALENCY BOND, R1 IS HYDROGEN, HALOGEN ALKYL, ALKOXY OR TRIFLUOROMETHYL, Y IS SATURATED, UNSATURATED, STRAIGHT OR BRANCHED CHAIN ALKYLENE CONTAINING UP TO 6 CARBON ATOMS OR SUCH ALKYLENE GROUP CONTAINING A NITROGEN OR OXYGEN ATOM, Z IS STRAIGHT OR BRANCHED CHAIN ALKLYENE CONTAINING UP TO 4 CARBON ATOMS AND R2 IS STRAIGHT OR BRANCHED CHAIN, SATURATED OR UNSTAURATED ALKYL OR CYCLOALKYL, AND SUCH GROUPS INTERRUPTED BY OXYGEN OR SULFUR ATOMS OR CONTAINNG AN ENDO-ALKYLENE GROUP, SUBSTITUTED OR UNSUBSTITUTED ARYL OR ARALKYL OR SUBSTTITUTED, UNSUBSTITUTED, SATUATED OR UNSATURATED ALKYLENE-IMINO CONTAINING 3 TO 7 CARBON ATOMS OR SUCH ALKYLENE-IMINOI CONTAINING AN ENDO-ALKYLENE GROUP. THE AFORESAID SULFONYL UREAS AND SULFONYL-SEMICARAZIDES CONSTITUTE EXTREMELY EFFECTIVE ANTI-DIABETIC AGENTS.

Inventors

• 👤 Werner Winter
• 👤 Erich Fauland
• 👤 Kurt Stach
• 👤 Felix Helmut Schinidt
• 👤 Walter Aumuller

Bibliographic Details