Patent US4052508A successfully refreshed from Google Patents.
US4052508A
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Heterocyclic dihydroanthracen imines
Assignee: Merck and Co Inc
•
Filing: 1975-04-07
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Granted: 1977-10-04
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Expires: 1995-04-07
Abstract
Abstract Heterocyclic dihydroanthracen imines are disclosed to be useful as minor tranquilizers, anticonvulsants, muscle relaxants and to be useful in the treatment of extrapyramidal disorders such as Parkinson's disease; also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions.
Inventors
- 👤 Paul S. Anderson
- 👤 Marcia E. Christy
- 👤 Gerald S. Ponticello
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 15:01
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/12; C07D471/18
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
100 words
A compound selected from the group consisting of: ##STR21## ##STR22## wherein R 1 and R 2 are selected from the group consisting of hydrogen, lower alkyl having from 1 to 6 carbon atoms, trifluoromethylsulfonyl, trifluoromethyl, dimethylaminopropyl; R is hydrogen or lower alkyl having from 1 to 6 carbon atoms, benzyl, dimethylaminopropyl, cyclopropyl, or cyclobutyl; X and Y are iodo, chloro, bromo, lower alkoxy having from 1 to 6 carbon atoms, lower alkyl having from 1 to 6 carbon atoms, thiomethyl, carboxamido, trifluoromethoxy, trifluoromethyl, trifluoromethylsulfonyl, and trifluoromethylthio; n is an integer selected from 0 (X or Y is hydrogen), and 1.
Claim 2
Dependent Claim
100 words
A compound selected from the group consisting of: ##STR21## ##STR22## wherein R 1 and R 2 are selected from the group consisting of hydrogen, lower alkyl having from 1 to 6 carbon atoms, trifluoromethylsulfonyl, trifluoromethyl, dimethylaminopropyl; R is hydrogen or lower alkyl having from 1 to 6 carbon atoms, benzyl, dimethylaminopropyl, cyclopropyl, or cyclobutyl; X and Y are iodo, chloro, bromo, lower alkoxy having from 1 to 6 carbon atoms, lower alkyl having from 1 to 6 carbon atoms, thiomethyl, carboxamido, trifluoromethoxy, trifluoromethyl, trifluoromethylsulfonyl, and trifluoromethylthio; n is an integer selected from 0 (X or Y is hydrogen), and 1.
Claim 3
Independent Claim
77 words
A method of producing a tranquilizing, muscle relaxant, anticonvulsant and/or anti-Parkinson effect in a patient in need of such treatment by the administration of an effective amount of a compound of formula: ##STR23## wherein R 1 and R 2 are selected from the group consisting of hydrogen, lower alkyl having from 1 to 6 carbon atoms, trifluoromethylsulfonyl, trifluoromethyl, dimethylaminopropyl; R is hydrogen or lower alkyl having from 1 to 6 carbon atoms, benzyl, dimethylaminopropyl, cyclopropyl, or cyclobutyl;
Claim 4
Independent Claim
77 words
A method of producing a tranquilizing, muscle relaxant, anticonvulsant and/or anti-Parkinson effect in a patient in need of such treatment by the administration of an effective amount of a compound of formula: ##STR23## wherein R 1 and R 2 are selected from the group consisting of hydrogen, lower alkyl having from 1 to 6 carbon atoms, trifluoromethylsulfonyl, trifluoromethyl, dimethylaminopropyl; R is hydrogen or lower alkyl having from 1 to 6 carbon atoms, benzyl, dimethylaminopropyl, cyclopropyl, or cyclobutyl;
Claim 5
Dependent Claim
46 words
X and Y are iodo, chloro, bromo, lower alkoxy having from 1 to 6 carbon atoms, lower alkyl having from 1 to 6 carbon atoms, thiomethyl, carboxamido, trifluoromethoxy, trifluoromethyl, trifluoromethylsulfonyl, and trifluoromethylthio; n is an integer selected from 0 (X or Y is hydrogen), and 1.
Claim 6
Dependent Claim
46 words
X and Y are iodo, chloro, bromo, lower alkoxy having from 1 to 6 carbon atoms, lower alkyl having from 1 to 6 carbon atoms, thiomethyl, carboxamido, trifluoromethoxy, trifluoromethyl, trifluoromethylsulfonyl, and trifluoromethylthio; n is an integer selected from 0 (X or Y is hydrogen), and 1.
Claim 7
Dependent Claim
121 words
A pharmaceutical composition for use as tranquilizer, muscle relaxant, anti-convulsant and/or anti-Parkinson agent in unit dosage form comprising a pharamaceutical carrier and an effective amount of a compound of formula: ##STR24## wherein R 1 and R 2 are selected from the group consisting of hydrogen, lower alkyl having from 1 to 6 carbon atoms, trifluoromethylsulfonyl, trifluoromethyl, dimethylaminopropyl; R is hydrogen or lower alkyl having from 1 to 6 carbon atoms, benzyl, dimethylaminopropyl, cyclopropyl, or cyclobutyl; X and Y are iodo, chloro, bromo, lower alkoxy having from 1 to 6 carbon atoms, lower alkyl having from 1 to 6 carbon atoms, thiomethyl, carboxamido, trifluoromethoxy, trifluoromethyl, trifluoromethylsulfonyl, and trifluoromethylthio; n is an integer selected from 0 (X or Y is hydrogen), and 1.
Claim 8
Dependent Claim
121 words
A pharmaceutical composition for use as tranquilizer, muscle relaxant, anti-convulsant and/or anti-Parkinson agent in unit dosage form comprising a pharamaceutical carrier and an effective amount of a compound of formula: ##STR24## wherein R 1 and R 2 are selected from the group consisting of hydrogen, lower alkyl having from 1 to 6 carbon atoms, trifluoromethylsulfonyl, trifluoromethyl, dimethylaminopropyl; R is hydrogen or lower alkyl having from 1 to 6 carbon atoms, benzyl, dimethylaminopropyl, cyclopropyl, or cyclobutyl; X and Y are iodo, chloro, bromo, lower alkoxy having from 1 to 6 carbon atoms, lower alkyl having from 1 to 6 carbon atoms, thiomethyl, carboxamido, trifluoromethoxy, trifluoromethyl, trifluoromethylsulfonyl, and trifluoromethylthio; n is an integer selected from 0 (X or Y is hydrogen), and 1.
Claim 9
Dependent Claim
3 words
The compound 1-aza-5,10-dihydro-11-methylanthracen-5,10-imine.
Claim 10
Dependent Claim
3 words
The compound 1-aza-5,10-dihydro-11-methylanthracen-5,10-imine.
Claim 11
Dependent Claim
3 words
The compound, 2-aza-5,10-dihydro-11-methylanthracen-5,10-imine.
Claim 12
Dependent Claim
3 words
The compound, 2-aza-5,10-dihydro-11-methylanthracen-5,10-imine.
Claim 13
Dependent Claim
3 words
The compound, 2-aza-5,10-dihydro-5,10,11-trimethylanthracen-5,10-imine.
Claim 14
Dependent Claim
3 words
The compound, 2-aza-5,10-dihydro-5,10,11-trimethylanthracen-5,10-imine.
Claim 15
Dependent Claim
3 words
The compound, 1-aza-5,10-dihydro-5,10,11-trimethylanthracen-5,10-imine.
Claim 16
Dependent Claim
3 words
The compound, 1-aza-5,10-dihydro-5,10,11-trimethylanthracen-5,10-imine.
References Cited (Backward Citations)
US3678072A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-03 | 1981-04-04 | 1981-10-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-03 | 1985-04-04 | 1985-10-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-03 | 1989-04-04 | 1989-10-04 | $7700.00 | Window Closed / Lapsed |