Patent US4050898A successfully refreshed from Google Patents.
US4050898A
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Integral analytical element
Assignee: Eastman Kodak Co
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Filing: 1976-04-26
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Granted: 1977-09-27
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Expires: 1996-04-26
Abstract
Abstract Analytical element for the detection of an agent under analysis, termed analyte, dissolved in an aqueous, proteinaceous liquid. The element has at least two superposed layers, the layers including a spreading layer and a reagent layer. The element can include a support material which is preferably radiation transmissive. To normalize transport of the analyte in and through the spreading layer, the spreading layer contains an effective amount of a surfactant, such as a non-ionic surfactant. Preferably, the amount of surfactant is between about 1% and about 15% by weight of solid contents in the spreading layer.
Inventors
- 👤 Charles A. Goffe, deceased
- 👤 Royden N. Rand
- 👤 Tai W. Wu
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:20
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/525
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
64 words
An element for detection of analyte dissolved in proteinaceous, aqueous liquids, the element comprising an isotropically porous spreading layer and a reagent layer, wherein the spreading layer comprises a non-fibrous, water-resistant material and an non-ionic surfactant, the surfactant being present in an amount within the range of from about 1 to about 15 percent and effective to normalize liquid transport in the spreading layer.
Claim 2
Dependent Claim
64 words
An element for detection of analyte dissolved in proteinaceous, aqueous liquids, the element comprising an isotropically porous spreading layer and a reagent layer, wherein the spreading layer comprises a non-fibrous, water-resistant material and an non-ionic surfactant, the surfactant being present in an amount within the range of from about 1 to about 15 percent and effective to normalize liquid transport in the spreading layer.
Claim 3
Dependent Claim
27 words
An element as described in claim 1 wherein the surfactant is in the spreading layer in an amount of from about 1 percent to about 10 percent.
Claim 4
Dependent Claim
27 words
An element as described in claim 1 wherein the surfactant is in the spreading layer in an amount of from about 3 percent to about 6 percent.
Claim 5
Dependent Claim
97 words
An element for detection of analyte dissolved in proteinaceous, aqueous liquids, the element comprising an isotropically porous spreading layer and a reagent layer, wherein the spreading layer comprises a non-fibrous, water-resistant material and a non-ionic surfactant having the formula ##STR2## wherein R represents an alkyl group of from 1 to about 9 carbon atoms and n represents an integer having a value of from about 5 to about 40, the surfactant being present in an amount within the range of from about 1 to about 15 percent and effective to normalize liquid transport in the spreading layer.
Claim 6
Dependent Claim
97 words
An element for detection of analyte dissolved in proteinaceous, aqueous liquids, the element comprising an isotropically porous spreading layer and a reagent layer, wherein the spreading layer comprises a non-fibrous, water-resistant material and a non-ionic surfactant having the formula ##STR2## wherein R represents an alkyl group of from 1 to about 9 carbon atoms and n represents an integer having a value of from about 5 to about 40, the surfactant being present in an amount within the range of from about 1 to about 15 percent and effective to normalize liquid transport in the spreading layer.
Claim 7
Dependent Claim
24 words
An element as described in claim 4 wherein the surfactant is present in an amount of from about 1 percent to about 10 percent.
Claim 8
Dependent Claim
27 words
An element as described in claim 5 wherein the surfactant is in the spreading layer in an amount of from about 3 percent to about 6 percent.
Claim 9
Dependent Claim
22 words
An element as described in claim 5 wherein the surfactant is an octylphenoxypolyethoxyethanol having from about 9 to about 40 ethoxy units.
Claim 10
Dependent Claim
24 words
An element as described in claim 7 wherein the surfactant is present in an amount of from about 1 percent to about 10 percent.
Claim 11
Dependent Claim
27 words
An element as described in claim 7 wherein the surfactant is in the spreading layer in an amount of from about 3 percent to about 6 percent.
Claim 12
Dependent Claim
85 words
An element for detection of analyte dissolved in proteinaceous, aqueous liquids, the element comprising an isotropically porous spreading layer and a reagent layer, wherein the spreading layer comprises a non-fibrous, water-resistant material and a non-ionic surfactant having the formula ##STR3## wherein R represents an octyl group or a nonyl group and n represents 9, 10 or 40, said surfactant being present in an amount within the range of from about 1 to about 15 percent and effective to normalize liquid transport in the spreading layer.
Claim 13
Dependent Claim
85 words
An element for detection of analyte dissolved in proteinaceous, aqueous liquids, the element comprising an isotropically porous spreading layer and a reagent layer, wherein the spreading layer comprises a non-fibrous, water-resistant material and a non-ionic surfactant having the formula ##STR3## wherein R represents an octyl group or a nonyl group and n represents 9, 10 or 40, said surfactant being present in an amount within the range of from about 1 to about 15 percent and effective to normalize liquid transport in the spreading layer.
Claim 14
Dependent Claim
26 words
An element as described in claim 10 wherein the surfactant is in said layer in an amount of from about 1 percent to about 10 percent.
Claim 15
Dependent Claim
27 words
An element as described in claim 11 wherein the surfactant is in the spreading layer in an amount of from about 3 percent to about 6 percent.
Claim 16
Dependent Claim
87 words
An element for detection of analyte dissolved in a proteinaceous, aqueous liquid, the element comprising a radiation transmissive support having thereon an isotropically porous spreading layer and a water-swellable reagent layer, wherein the reagent layer is interposed between the support and the spreading layer and wherein the spreading layer comprises a non-fibrous, water-resistant material and a non-ionic surfactant, the surfactant being present in an amount within the range of from about 1 percent to about 15 percent and effective to normalize liquid transport in the spreading layer.
Claim 17
Dependent Claim
87 words
An element for detection of analyte dissolved in a proteinaceous, aqueous liquid, the element comprising a radiation transmissive support having thereon an isotropically porous spreading layer and a water-swellable reagent layer, wherein the reagent layer is interposed between the support and the spreading layer and wherein the spreading layer comprises a non-fibrous, water-resistant material and a non-ionic surfactant, the surfactant being present in an amount within the range of from about 1 percent to about 15 percent and effective to normalize liquid transport in the spreading layer.
Claim 18
Dependent Claim
27 words
An element as described in claim 13 wherein the surfactant is in the spreading layer in an amount of from about 1 percent to about 10 percent.
Claim 19
Dependent Claim
27 words
An element as described in claim 14 wherein the surfactant is in the spreading layer in an amount of from about 3 percent to about 6 percent.
Claim 20
Dependent Claim
116 words
An element for detection of analyte dissolved in a proteinaceous, aqueous liquid, the element comprising a radiation-transmissive support having thereon, in fluid contact, an isotropically porous spreading layer and a water-swellable reagent layer of lower permeability than the spreading layer, wherein the reagent layer is interposed between the support and the spreading layer and wherein the spreading layer comprises a non-fibrous, water-resistant material and a non-ionic surfactant having the formula ##STR4## wherein R represents an alkyl group of from 1 to about 9 carbon atoms and n represents an integer having a value of from about 5 to about 40, the surfactant being present in an amount effective to normalize liquid transport in the spreading layer.
Claim 21
Dependent Claim
116 words
An element for detection of analyte dissolved in a proteinaceous, aqueous liquid, the element comprising a radiation-transmissive support having thereon, in fluid contact, an isotropically porous spreading layer and a water-swellable reagent layer of lower permeability than the spreading layer, wherein the reagent layer is interposed between the support and the spreading layer and wherein the spreading layer comprises a non-fibrous, water-resistant material and a non-ionic surfactant having the formula ##STR4## wherein R represents an alkyl group of from 1 to about 9 carbon atoms and n represents an integer having a value of from about 5 to about 40, the surfactant being present in an amount effective to normalize liquid transport in the spreading layer.
Claim 22
Dependent Claim
162 words
An element for detection of analyte dissolved in a proteinaceous, aqueous liquid, the element comprising a radiation-transmissive support having thereon (a) an isotropically porous, water-resistant spreading layer comprising (i) a member selected from the group consisting of a non-fibrous, isotropically porous material and particulate matter, and (ii) a non-ionic surfactant having the formula ##STR5## wherein R represents an alkyl group of from 1 to about 9 carbon atoms and n represents an integer having a value of from about 5 to about 40, the surfactant being present in an amount within the range of from about 1 to about 15 percent and effective to normalize liquid transport in the spreading layer, and (b) a water-swellable reagent layer comprising a hydrophilic colloid matrix having distributed therein a material interactive in the presence of analyte or a precursor or a reaction product thereof to produce a detectable change in the element, wherein the reagent layer is interposed between the support and the spreading layer.
Claim 23
Dependent Claim
162 words
An element for detection of analyte dissolved in a proteinaceous, aqueous liquid, the element comprising a radiation-transmissive support having thereon (a) an isotropically porous, water-resistant spreading layer comprising (i) a member selected from the group consisting of a non-fibrous, isotropically porous material and particulate matter, and (ii) a non-ionic surfactant having the formula ##STR5## wherein R represents an alkyl group of from 1 to about 9 carbon atoms and n represents an integer having a value of from about 5 to about 40, the surfactant being present in an amount within the range of from about 1 to about 15 percent and effective to normalize liquid transport in the spreading layer, and (b) a water-swellable reagent layer comprising a hydrophilic colloid matrix having distributed therein a material interactive in the presence of analyte or a precursor or a reaction product thereof to produce a detectable change in the element, wherein the reagent layer is interposed between the support and the spreading layer.
Claim 24
Dependent Claim
25 words
An analytical element as described in claim 17 wherein the surfactant is present in an amount of from about 1 percent to about 10 percent.
Claim 25
Dependent Claim
165 words
An element for detection of analyte dissolved in a proteinaceous, aqueous liquid, the element comprising a radiation-transmissive support having thereon (a) an isotropically porous, water-resistant spreading layer comprising (i) a member selected from the group consisting of a blush polymer, a colloid derived from a polymer, and a pigment, and (ii) a surfactant having the formula ##STR6## wherein R represents an alkyl group of from 1 to about 9 carbon atoms and n represents an integer having a value of from about 5 to about 40, the surfactant being present in an amount within the range of from about 1 to about 15 percent and effective to normalize liquid transport in the spreading layer, and (b) a water-swellable reagent layer comprising a hydrophilic colloid matrix having distributed therein a material interactive in the presence of analyte or a precursor or a reaction product thereof to produce a detectable change in the element, wherein the reagent layer is interposed between the support and the spreading layer.
Claim 26
Dependent Claim
165 words
An element for detection of analyte dissolved in a proteinaceous, aqueous liquid, the element comprising a radiation-transmissive support having thereon (a) an isotropically porous, water-resistant spreading layer comprising (i) a member selected from the group consisting of a blush polymer, a colloid derived from a polymer, and a pigment, and (ii) a surfactant having the formula ##STR6## wherein R represents an alkyl group of from 1 to about 9 carbon atoms and n represents an integer having a value of from about 5 to about 40, the surfactant being present in an amount within the range of from about 1 to about 15 percent and effective to normalize liquid transport in the spreading layer, and (b) a water-swellable reagent layer comprising a hydrophilic colloid matrix having distributed therein a material interactive in the presence of analyte or a precursor or a reaction product thereof to produce a detectable change in the element, wherein the reagent layer is interposed between the support and the spreading layer.
Claim 27
Dependent Claim
25 words
An analytical element as described in claim 19 wherein the surfactant is present in an amount of from about 1 percent to about 10 percent.
Claim 28
Dependent Claim
22 words
An element as described in claim 19 wherein the surfactant is an octylphenoxypolyethoxyethanol having from about 9 to about 40 ethoxy units.
Claim 29
Dependent Claim
27 words
An element as described in claim 21 wherein the surfactant is in the spreading layer in an amount of from about 3 percent to about 6 percent.
Claim 30
Independent Claim
102 words
A method for determining the concentration of analyte dissolved in a proteinaceous, aqueous liquid, the method comprising (a) applying a sample of proteinaceous, aqueous liquid to an element comprising an isotropically porous spreading layer and a reagent layer, wherein the spreading layer comprises a non-fibrous, water-resistant material and a non-ionic surfactant in an amount within the range of from about 1 to about 15 percent and effective to normalize liquid transport in the spreading layer, to effect a detectable change in the element in the presence of an analyte within the sample, and (b) detecting any such change produced in the element.
Claim 31
Independent Claim
102 words
A method for determining the concentration of analyte dissolved in a proteinaceous, aqueous liquid, the method comprising (a) applying a sample of proteinaceous, aqueous liquid to an element comprising an isotropically porous spreading layer and a reagent layer, wherein the spreading layer comprises a non-fibrous, water-resistant material and a non-ionic surfactant in an amount within the range of from about 1 to about 15 percent and effective to normalize liquid transport in the spreading layer, to effect a detectable change in the element in the presence of an analyte within the sample, and (b) detecting any such change produced in the element.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-09-26 | 1981-03-28 | 1981-09-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-09-26 | 1985-03-28 | 1985-09-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-09-26 | 1989-03-28 | 1989-09-27 | $7700.00 | Window Closed / Lapsed |